Best Retinoblastoma Protein Antibody

Evaluation of the expression and affiliation of retinoblastoma binding protein 6 (RBBP6) with the JNK signaling pathway in prostate cancers

 

 

This research goals to research the expression of retinoblastoma binding protein 6 (RBBP6) in prostate most cancers (PCa) and its affiliation with the c-Jun N-terminal kinase (JNK) pathway.
Immunohistochemistry was used to detect RBBP6 and JNK1/2 expression in PCa and benign prostatic hyperplasia (BPH) tissues.
RBBP6 expression in PCa cells (LNCap, PC3 and DU145) and noncancerous prostate epithelial cells (RWPE-1) was decided by qRT-PCR and Western blotting. PC3 and DU145 cells had been transfected with RBBP6 siRNAs to look at the organic traits. Anisomycin (a JNK activator) with/with out RBBP6 siRNA was used to deal with PC3 cells for additional investigating the ramification of the RBBP6-mediated JNK pathway in PCa. PCa tissues and cells confirmed larger RBBP6 and JNK1/2 expression.

Recombinant Retinoblastoma Protein 1 (RB1)

RBBP6 was positively correlated with JNK1/2 in PCa tissues. Apart from, RBBP6 expression was correlated to scientific tumor stage, lymph node metastasis, Gleason grade, preoperative PSA degree, in addition to prognosis of PCa. RBBP6 siRNA lowered cell proliferation, arrested cells at G2/M, and promoted cell apoptosis, and suppressed JNK pathway.
Moreover, migration and invasion decreased after the RBBP6 siRNA transfection with downregulated MMP-2 and MMP-9. Anisomycin promoted the proliferation, invasion and migration of PC3 cells and inhibited PC3 cell apoptosis, which could possibly be reversed by RBBP6 siRNA. RBBP6 expression was upregulated in PCa tissues and positively correlated with expression degree of JNK1/2.
With inhibition of RBBP6 expression, the proliferation, invasion and migration of PCa cells decreased dramatically, whereas PC3 cell apoptosis elevated appreciably, accompanied by suppression of the JNK pathway. This text is protected by copyright. All rights reserved.

Retinoblastoma Protein 1 Phospho-Thr826 (RB1 pT826) Antibody

Key phrases: Apoptosis; Most cancers; Cell migration; Gene remedy.

Retinoblastoma Protein 1 (RB1) Antibody

20-abx001728
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Retinoblastoma Protein 1 (RB1) Antibody

20-abx008782
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Retinoblastoma Protein 1 (RB1) Antibody

20-abx121694
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Retinoblastoma Protein 1 (RB1) Antibody

20-abx123188
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Retinoblastoma Protein 1 (RB1) Antibody

20-abx126458
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Retinoblastoma Protein 1 (RB1) Antibody

abx011911-100ul 100 ul
EUR 493.2

Retinoblastoma Protein 1 (RB1) Antibody

abx032759-400ul 400 ul
EUR 627.6

Retinoblastoma Protein 1 (RB1) Antibody

abx032759-80l 80 µl
EUR 343.2

Retinoblastoma Protein 1 (RB1) Antibody

abx034004-400ul 400 ul
EUR 627.6

Retinoblastoma Protein 1 (RB1) Antibody

abx034004-80l 80 µl
EUR 343.2

Retinoblastoma Protein 1 (RB1) Antibody

abx037361-100ug 100 ug
EUR 469.2

Retinoblastoma Protein 1 (RB1) Antibody

20-abx320518
  • EUR 360.00
  • EUR 292.80
  • 100 ul
  • 50 ul

Retinoblastoma Protein 1 (RB1) Antibody

20-abx329342
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 (RB1) Antibody

20-abx329620
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 (RB1) Antibody

abx331681-100ul 100 ul
EUR 510

Retinoblastoma Protein 1 (RB1) Antibody

abx332050-100ul 100 ul
EUR 510

Retinoblastoma Protein 1 (RB1) Antibody

abx332098-100ul 100 ul
EUR 510

Retinoblastoma Protein 1 (RB1) Antibody

abx332214-100ul 100 ul
EUR 510

Retinoblastoma Protein 1 (RB1) Antibody

20-abx326789
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 (RB1) Antibody

20-abx326790
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 (RB1) Antibody

20-abx326791
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 (RB1) Antibody

20-abx328550
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 (RB1) Antibody

20-abx328752
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 (RB1) Antibody

20-abx214314
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Retinoblastoma Protein 1 (RB1) Antibody

abx237141-100ug 100 ug
EUR 610.8

Retinoblastoma Protein 1 (RB1) Antibody

abx237142-100ug 100 ug
EUR 661.2

Retinoblastoma Antibody / Rb1

RQ5140 100ul
EUR 419

Retinoblastoma Antibody / Rb1

RQ5141 100ul
EUR 419

Retinoblastoma Antibody / Rb1

F54327-0.05ML 0.05 ml
EUR 165

Retinoblastoma Antibody / Rb1

F54327-0.2ML 0.2 ml
EUR 379

Retinoblastoma Antibody / Rb1

V3218-100UG 100 ug
EUR 499
Description: The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. When the cell is ready to divide, pRb is phosphorylated, becomes inactive and allows cell cycle progression. It is also a recruiter of several chromatin remodeling enzymes such as methylases and acetylases.

Rb restricts the cell's ability to replicate DNA by preventing its progression from the G1 (first gap phase) to S (synthesis phase) phase of the cell division cycle. Rb binds and inhibits transcription factors of the E2F family, which are composed of dimers of an E2F protein and a dimerization partner (DP) protein. The transcription activating complexes of E2 promoter-binding–protein-dimerization partners (E2F-DP) can push a cell into S phase. As long as E2F-DP is inactivated, the cell remains stalled in the G1 phase. When Rb is bound to E2F, the complex acts as a growth suppressor and prevents progression through the cell cycle. The Rb-E2F/DP complex also attracts a histone deacetylase (HDAC) protein to the chromatin, reducing transcription of S phase promoting factors, further suppressing DNA synthesis.[Wiki]

mAb 1F8 ecognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein.

Retinoblastoma Antibody / Rb1

V3218-20UG 20 ug
EUR 219
Description: The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. When the cell is ready to divide, pRb is phosphorylated, becomes inactive and allows cell cycle progression. It is also a recruiter of several chromatin remodeling enzymes such as methylases and acetylases.

Rb restricts the cell's ability to replicate DNA by preventing its progression from the G1 (first gap phase) to S (synthesis phase) phase of the cell division cycle. Rb binds and inhibits transcription factors of the E2F family, which are composed of dimers of an E2F protein and a dimerization partner (DP) protein. The transcription activating complexes of E2 promoter-binding–protein-dimerization partners (E2F-DP) can push a cell into S phase. As long as E2F-DP is inactivated, the cell remains stalled in the G1 phase. When Rb is bound to E2F, the complex acts as a growth suppressor and prevents progression through the cell cycle. The Rb-E2F/DP complex also attracts a histone deacetylase (HDAC) protein to the chromatin, reducing transcription of S phase promoting factors, further suppressing DNA synthesis.[Wiki]

mAb 1F8 ecognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein.

Retinoblastoma Antibody / Rb1

V3218SAF-100UG 100 ug
EUR 499
Description: The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. When the cell is ready to divide, pRb is phosphorylated, becomes inactive and allows cell cycle progression. It is also a recruiter of several chromatin remodeling enzymes such as methylases and acetylases.

Rb restricts the cell's ability to replicate DNA by preventing its progression from the G1 (first gap phase) to S (synthesis phase) phase of the cell division cycle. Rb binds and inhibits transcription factors of the E2F family, which are composed of dimers of an E2F protein and a dimerization partner (DP) protein. The transcription activating complexes of E2 promoter-binding–protein-dimerization partners (E2F-DP) can push a cell into S phase. As long as E2F-DP is inactivated, the cell remains stalled in the G1 phase. When Rb is bound to E2F, the complex acts as a growth suppressor and prevents progression through the cell cycle. The Rb-E2F/DP complex also attracts a histone deacetylase (HDAC) protein to the chromatin, reducing transcription of S phase promoting factors, further suppressing DNA synthesis.[Wiki]

mAb 1F8 ecognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein.

Retinoblastoma Antibody / Rb1

V3438-100UG 100 ug
EUR 499
Description: Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

Retinoblastoma Antibody / Rb1

V3438-20UG 20 ug
EUR 219
Description: Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

Retinoblastoma Antibody / Rb1

V3438SAF-100UG 100 ug
EUR 499
Description: Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

Retinoblastoma Antibody / Rb1

V3439-100UG 100 ug
EUR 499
Description: Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It reacts with the hyper-phosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

Retinoblastoma Antibody / Rb1

V3439-20UG 20 ug
EUR 219
Description: Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It reacts with the hyper-phosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

Retinoblastoma Antibody / Rb1

V3439SAF-100UG 100 ug
EUR 499
Description: Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It reacts with the hyper-phosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

Retinoblastoma Antibody / Rb1

V3578-100UG 100 ug
EUR 499
Description: Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

Retinoblastoma Antibody / Rb1

V3578-20UG 20 ug
EUR 219
Description: Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

Retinoblastoma Antibody / Rb1

V3578IHC-7ML 7 ml
EUR 499
Description: Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

Retinoblastoma Antibody / Rb1

V3578SAF-100UG 100 ug
EUR 499
Description: Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

Retinoblastoma Protein 1 (RB1) Protein

20-abx260454
  • EUR 276.00
  • EUR 2798.40
  • EUR 393.60
  • 10 ug
  • 1 mg
  • 50 ug

Recombinant Retinoblastoma Protein 1 (RB1)

4-RPB211Hu01
  • EUR 507.07
  • EUR 259.20
  • EUR 1571.52
  • EUR 603.84
  • EUR 1087.68
  • EUR 415.20
  • EUR 3748.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Retinoblastoma Protein 1 expressed in: E.coli

Recombinant Retinoblastoma Protein 1 (RB1)

4-RPB211Hu02
  • EUR 507.07
  • EUR 259.20
  • EUR 1571.52
  • EUR 603.84
  • EUR 1087.68
  • EUR 415.20
  • EUR 3748.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Retinoblastoma Protein 1 expressed in: E.coli

Retinoblastoma Protein 1 (Rb1) Antibody Pair

abx117561-1pair5x96wellplates 1 pair (5x96 well plates)
EUR 1212

Retinoblastoma Protein 1 (RB1) Antibody (Biotin)

20-abx272104
  • EUR 543.60
  • EUR 292.80
  • EUR 1579.20
  • EUR 744.00
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rat Retinoblastoma-associated protein (Rb1)

1-CSB-RP155294r(A3)
  • EUR 606.00
  • EUR 318.00
  • EUR 2192.40
  • EUR 919.20
  • EUR 1461.60
  • EUR 402.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Rat Retinoblastoma-associated protein(Rb1),partial expressed in E.coli

Human Retinoblastoma Protein 1 (RB1) Protein

20-abx068874
  • EUR 710.40
  • EUR 309.60
  • EUR 2131.20
  • EUR 844.80
  • EUR 526.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Retinoblastoma Protein 1 (RB1) Protein

20-abx068875
  • EUR 710.40
  • EUR 309.60
  • EUR 2131.20
  • EUR 844.80
  • EUR 526.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Retinoblastoma Protein 1 (RB1) Polyclonal Antibody (Human)

4-PAB211Hu01
  • EUR 286.80
  • EUR 2869.20
  • EUR 717.60
  • EUR 358.80
  • EUR 253.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Retinoblastoma Protein 1 (RB1)

Retinoblastoma Protein 1 (RB1) Polyclonal Antibody (Human)

4-PAB211Hu02
  • EUR 286.80
  • EUR 2869.20
  • EUR 717.60
  • EUR 358.80
  • EUR 253.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Retinoblastoma Protein 1 (RB1)

Retinoblastoma Protein 1 Phospho-Ser807 (RB1 pS807) Antibody

20-abx125454
  • EUR 710.40
  • EUR 1028.40
  • EUR 493.20
  • 100 ul
  • 200 ul
  • 50 ul

Retinoblastoma Protein 1 Phospho-Ser612 (RB1 pS612) Antibody

20-abx323083
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 Phospho-Thr826 (RB1 pT826) Antibody

abx333137-100ul 100 ul
EUR 560.4

Retinoblastoma Protein 1 Phospho-Ser780 (RB1 pS780) Antibody

abx333182-100ul 100 ul
EUR 560.4

Retinoblastoma Protein 1 Phospho-Ser795 (RB1 pS795) Antibody

abx333183-100ul 100 ul
EUR 560.4

Retinoblastoma Protein 1 Phospho-Ser807 (RB1 pS807) Antibody

abx333270-100ul 100 ul
EUR 560.4

Retinoblastoma Protein 1 Phospho-Ser780 (RB1 pS780) Antibody

20-abx329208
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 Phospho-Ser811 (RB1 pS811) Antibody

20-abx329209
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 Phospho-Thr826 (RB1 pT826) Antibody

20-abx329210
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 Phospho-Ser249 (RB1 pS249) Antibody

20-abx326387
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 Phospho-Ser788 (RB1 pS788) Antibody

20-abx326427
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 Phospho-Thr821 (RB1 pT821) Antibody

20-abx326768
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 Phospho-Ser795 (RB1 pS795) Antibody

20-abx328301
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 Phospho-Ser807 (RB1 pS807) Antibody

20-abx328302
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 Phospho-Ser608 (RB1 pS608) Antibody

20-abx328753
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

 

 

Retinoblastoma protein expression and its predictors in triple-negative breast most cancers

 

  • BACKGROUND Lengthy noncoding RNA (lncRNA) acts as key regulator in human cancers, together with retinoblastoma. Nonetheless, the perform of LINC00152 stays largely unknown in retinoblastoma.

            Phospho- Retinoblastoma (Ser780) Antibody

Retinoblastoma (Phospho-Thr373) Antibody detects endogenous ranges of Retinoblastoma solely when phosphorylated at Thr373.

  • Thus, this research aimed to discover the function and molecular mechanisms of LINC00152 in retinoblastoma. MATERIAL AND METHODS The true-time quantitative polymerase chain response (RT-qPCR) was used to quantify the expression ranges of LINC00152, miR-613 and yes-associated protein 1 (YAP1). The target genes of LINC00152 and miR-613 had been recognized by dual-luciferase reporter evaluation, RNA immunoprecipitation (RIP) and RNA pulldown assays.

 

  • The viability, apoptosis, and invasion of retinoblastoma cells had been assessed by Cell Counting Package-8, move cytometry, and Transwell assays, respectively. As well as, western blot was used to check the protein expression in retinoblastoma cells or tissues. Cell sensitivity to carboplatin and adriamycin was analyzed by computing IC₅₀ worth.

Retinoblastoma Antibody

20-abx012903
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Retinoblastoma Antibody

ABF6103 100 ug
EUR 525.6

Retinoblastoma Antibody

AF7698 200ul
EUR 540

Retinoblastoma Antibody

DF6840 200ul
EUR 420

Retinoblastoma Antibody

AF6103 200ul
EUR 420

Retinoblastoma Antibody

F51209-0.4ML 0.4 ml
EUR 379

Retinoblastoma antibody (Ser788)

70R-32616 100 ug
EUR 392.4
Description: Rabbit polyclonal Retinoblastoma antibody (Ser788)

Retinoblastoma antibody (Ser608)

70R-32617 100 ug
EUR 392.4
Description: Rabbit polyclonal Retinoblastoma antibody (Ser608)

Retinoblastoma antibody (Ser249)

70R-33653 100 ug
EUR 392.4
Description: Rabbit polyclonal Retinoblastoma antibody (Ser249)

Retinoblastoma antibody (Thr826)

70R-33655 100 ug
EUR 392.4
Description: Rabbit polyclonal Retinoblastoma antibody (Thr826)

Retinoblastoma (pS780) Antibody

20-abx119318
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Retinoblastoma (pS807) Antibody

20-abx119319
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Retinoblastoma 1 Antibody

20-abx115146
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Retinoblastoma (pT826) Antibody

abx011460-100ug 100 ug
EUR 526.8

Retinoblastoma (pS780) Antibody

abx011461-100ug 100 ug
EUR 526.8

Retinoblastoma (pS795) Antibody

abx011462-100ug 100 ug
EUR 526.8

Retinoblastoma (pS807) Antibody

abx011463-100ug 100 ug
EUR 526.8

Retinoblastoma (pS612) Antibody

abx218208-100ug 100 ug
EUR 526.8

Retinoblastoma (pT252) Antibody

abx218209-100ug 100 ug
EUR 526.8

Retinoblastoma (pS788) Antibody

abx218210-100ug 100 ug
EUR 526.8

Retinoblastoma (pT373) Antibody

abx218211-100ug 100 ug
EUR 526.8

Retinoblastoma Antibody / Rb1

RQ5140 100ul
EUR 419

Retinoblastoma Antibody / Rb1

RQ5141 100ul
EUR 419

Rb Antibody (Retinoblastoma)

F49535-0.08ML 0.08 ml
EUR 165

Rb Antibody (Retinoblastoma)

F51209-0.08ML 0.08 ml
EUR 165

Retinoblastoma Antibody / Rb1

F54327-0.05ML 0.05 ml
EUR 165

Retinoblastoma Antibody / Rb1

F54327-0.2ML 0.2 ml
EUR 379

Retinoblastoma Antibody / Rb1

V3218-100UG 100 ug
EUR 499
Description: The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. When the cell is ready to divide, pRb is phosphorylated, becomes inactive and allows cell cycle progression. It is also a recruiter of several chromatin remodeling enzymes such as methylases and acetylases.

Rb restricts the cell's ability to replicate DNA by preventing its progression from the G1 (first gap phase) to S (synthesis phase) phase of the cell division cycle. Rb binds and inhibits transcription factors of the E2F family, which are composed of dimers of an E2F protein and a dimerization partner (DP) protein. The transcription activating complexes of E2 promoter-binding–protein-dimerization partners (E2F-DP) can push a cell into S phase. As long as E2F-DP is inactivated, the cell remains stalled in the G1 phase. When Rb is bound to E2F, the complex acts as a growth suppressor and prevents progression through the cell cycle. The Rb-E2F/DP complex also attracts a histone deacetylase (HDAC) protein to the chromatin, reducing transcription of S phase promoting factors, further suppressing DNA synthesis.[Wiki]

mAb 1F8 ecognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein.

Retinoblastoma Antibody / Rb1

V3218-20UG 20 ug
EUR 219
Description: The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. When the cell is ready to divide, pRb is phosphorylated, becomes inactive and allows cell cycle progression. It is also a recruiter of several chromatin remodeling enzymes such as methylases and acetylases.

Rb restricts the cell's ability to replicate DNA by preventing its progression from the G1 (first gap phase) to S (synthesis phase) phase of the cell division cycle. Rb binds and inhibits transcription factors of the E2F family, which are composed of dimers of an E2F protein and a dimerization partner (DP) protein. The transcription activating complexes of E2 promoter-binding–protein-dimerization partners (E2F-DP) can push a cell into S phase. As long as E2F-DP is inactivated, the cell remains stalled in the G1 phase. When Rb is bound to E2F, the complex acts as a growth suppressor and prevents progression through the cell cycle. The Rb-E2F/DP complex also attracts a histone deacetylase (HDAC) protein to the chromatin, reducing transcription of S phase promoting factors, further suppressing DNA synthesis.[Wiki]

mAb 1F8 ecognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein.

Retinoblastoma Antibody / Rb1

V3218SAF-100UG 100 ug
EUR 499
Description: The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. When the cell is ready to divide, pRb is phosphorylated, becomes inactive and allows cell cycle progression. It is also a recruiter of several chromatin remodeling enzymes such as methylases and acetylases.

Rb restricts the cell's ability to replicate DNA by preventing its progression from the G1 (first gap phase) to S (synthesis phase) phase of the cell division cycle. Rb binds and inhibits transcription factors of the E2F family, which are composed of dimers of an E2F protein and a dimerization partner (DP) protein. The transcription activating complexes of E2 promoter-binding–protein-dimerization partners (E2F-DP) can push a cell into S phase. As long as E2F-DP is inactivated, the cell remains stalled in the G1 phase. When Rb is bound to E2F, the complex acts as a growth suppressor and prevents progression through the cell cycle. The Rb-E2F/DP complex also attracts a histone deacetylase (HDAC) protein to the chromatin, reducing transcription of S phase promoting factors, further suppressing DNA synthesis.[Wiki]

mAb 1F8 ecognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein.

Retinoblastoma Antibody / Rb1

V3438-100UG 100 ug
EUR 499
Description: Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

Retinoblastoma Antibody / Rb1

V3438-20UG 20 ug
EUR 219
Description: Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

Retinoblastoma Antibody / Rb1

V3438SAF-100UG 100 ug
EUR 499
Description: Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

Retinoblastoma Antibody / Rb1

V3439-100UG 100 ug
EUR 499
Description: Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It reacts with the hyper-phosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

Retinoblastoma Antibody / Rb1

V3439-20UG 20 ug
EUR 219
Description: Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It reacts with the hyper-phosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

Retinoblastoma Antibody / Rb1

V3439SAF-100UG 100 ug
EUR 499
Description: Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It reacts with the hyper-phosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

Retinoblastoma Antibody / Rb1

V3578-100UG 100 ug
EUR 499
Description: Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

Retinoblastoma Antibody / Rb1

V3578-20UG 20 ug
EUR 219
Description: Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

Retinoblastoma Antibody / Rb1

V3578IHC-7ML 7 ml
EUR 499
Description: Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

Retinoblastoma Antibody / Rb1

V3578SAF-100UG 100 ug
EUR 499
Description: Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

Retinoblastoma Protein 1 (RB1) Antibody

20-abx136094
  • EUR 493.20
  • EUR 710.40
  • 100 ul
  • 200 ul

Retinoblastoma Protein 1 (RB1) Antibody

20-abx141027
  • EUR 427.20
  • EUR 644.40
  • EUR 260.40
  • 100 ul
  • 200 ul
  • 30 ul

Retinoblastoma Protein 1 (RB1) Antibody

20-abx141070
  • EUR 427.20
  • EUR 644.40
  • EUR 260.40
  • 100 ul
  • 200 ul
  • 30 ul

Retinoblastoma Protein 1 (RB1) Antibody

20-abx141167
  • EUR 427.20
  • EUR 644.40
  • EUR 260.40
  • 100 ul
  • 200 ul
  • 30 ul

Retinoblastoma Protein 1 (RB1) Antibody

20-abx102399
  • EUR 493.20
  • EUR 159.60
  • EUR 1378.80
  • EUR 678.00
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Retinoblastoma Protein 1 (RB1) Antibody

20-abx102401
  • EUR 493.20
  • EUR 159.60
  • EUR 1378.80
  • EUR 678.00
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Retinoblastoma Protein 1 (RB1) Antibody

20-abx001728
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Retinoblastoma Protein 1 (RB1) Antibody

20-abx008782
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Retinoblastoma Protein 1 (RB1) Antibody

20-abx121694
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Retinoblastoma Protein 1 (RB1) Antibody

20-abx123188
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Retinoblastoma Protein 1 (RB1) Antibody

20-abx126458
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Retinoblastoma Protein 1 (RB1) Antibody

abx011911-100ul 100 ul
EUR 493.2

Retinoblastoma Protein 1 (RB1) Antibody

abx032759-400ul 400 ul
EUR 627.6

Retinoblastoma Protein 1 (RB1) Antibody

abx032759-80l 80 µl
EUR 343.2

Retinoblastoma Protein 1 (RB1) Antibody

abx034004-400ul 400 ul
EUR 627.6

Retinoblastoma Protein 1 (RB1) Antibody

abx034004-80l 80 µl
EUR 343.2

Retinoblastoma Protein 1 (RB1) Antibody

abx037361-100ug 100 ug
EUR 469.2

Retinoblastoma Protein 1 (RB1) Antibody

20-abx320518
  • EUR 360.00
  • EUR 292.80
  • 100 ul
  • 50 ul

Retinoblastoma Protein 1 (RB1) Antibody

20-abx329342
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 (RB1) Antibody

20-abx329620
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 (RB1) Antibody

abx331681-100ul 100 ul
EUR 510

Retinoblastoma Protein 1 (RB1) Antibody

abx332050-100ul 100 ul
EUR 510

Retinoblastoma Protein 1 (RB1) Antibody

abx332098-100ul 100 ul
EUR 510

Retinoblastoma Protein 1 (RB1) Antibody

abx332214-100ul 100 ul
EUR 510

Retinoblastoma Protein 1 (RB1) Antibody

20-abx326789
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 (RB1) Antibody

20-abx326790
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 (RB1) Antibody

20-abx326791
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 (RB1) Antibody

20-abx328550
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 (RB1) Antibody

20-abx328752
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Retinoblastoma Protein 1 (RB1) Antibody

20-abx214314
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Retinoblastoma Protein 1 (RB1) Antibody

abx237141-100ug 100 ug
EUR 610.8

Retinoblastoma Protein 1 (RB1) Antibody

abx237142-100ug 100 ug
EUR 661.2

Retinoblastoma (Phospho-Ser608) Antibody

11720-100ul 100ul
EUR 302.4

Retinoblastoma (Phospho-Ser608) Antibody

11720-50ul 50ul
EUR 224.4

Retinoblastoma (Phospho-Thr826) Antibody

12106-100ul 100ul
EUR 302.4

Retinoblastoma (Phospho-Thr826) Antibody

12106-50ul 50ul
EUR 224.4

Retinoblastoma (Phospho-Ser612) Antibody

12435-100ul 100ul
EUR 302.4

Retinoblastoma (Phospho-Ser612) Antibody

12435-50ul 50ul
EUR 224.4

Retinoblastoma (Phospho-Thr252) Antibody

12482-100ul 100ul
EUR 302.4

Retinoblastoma (Phospho-Thr252) Antibody

12482-50ul 50ul
EUR 224.4

Retinoblastoma (Phospho-Ser788) Antibody

12483-100ul 100ul
EUR 302.4

Retinoblastoma (Phospho-Ser788) Antibody

12483-50ul 50ul
EUR 224.4

Retinoblastoma (Phospho-Thr373) Antibody

12695-100ul 100ul
EUR 302.4

Retinoblastoma (Phospho-Thr373) Antibody

12695-50ul 50ul
EUR 224.4

Retinoblastoma (Ab-608) Antibody

33220-100ul 100ul
EUR 302.4

Retinoblastoma (Ab-608) Antibody

33220-50ul 50ul
EUR 224.4

Retinoblastoma (Phospho-Ser608) Antibody

20-abx012584
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Phospho-Retinoblastoma (Thr826) Antibody

A1733-100
EUR 574.8
  • The consequences of LINC00152 silencing in vivo had been measured by a xenograft experiment. RESULTS LINC00152 was clearly upregulated, whereas miR-613 was decreased in retinoblastoma tissues and cells. MiR-613, a goal of LINC00152, was negatively regulated by LINC00152. Purposeful experiment additional illustrated that silencing of LINC00152 evidently repressed proliferation, invasion, and autophagy whereas strengthened apoptosis of retinoblastoma cells, moreover, retinoblastoma cells had been extra delicate to carboplatin and adriamycin after knockdown of LINC00152.

 

              Retinoblastoma Protein 1 (RB1) Polyclonal Antibody (Human)

  • Importantly, knockdown of LINC00152-induced results on retinoblastoma cells could possibly be overturned by introducing miR-613 inhibitor. Downregulation of miR-613 abolished silencing of YAP1-effects on proliferation, apoptosis, invasion, autophagy, and chemoresistance of retinoblastoma cells.

 

  • The outcomes of the xenograft experiment indicated that LINC00152 silencing impeded tumor development in vivo. CONCLUSIONS Mechanistically, LINC00152 enhanced the aggressiveness of retinoblastoma and boosted carboplatin and adriamycin resistance by regulating YAP1 by sponging miR-613 in human retinoblastoma.