Posted in Antibodies, Assay Kits, Biology Cells, cDNA, Clia Kits, Culture Cells, Devices, DNA, DNA Templates, DNA Testing, Elisa Kits, Enzymes, Equipments, Exosomes, Gels, Isotypes, Medium & Serums, NATtrol, Panel, Particles, PCR, Pcr Kits, Peptides, Reagents, Recombinant Proteins, Ria Kits, RNA, Test Kits, Vector & Virus, Western Blot

Best tumor suppressor protein

TOPORS, a tumor suppressor protein, contributes to the maintenance of higher-order chromatin architecture.

 

  • Within the nucleus, chromosomes are hierarchically folded into lively (A) and inactive (B) compartments composed of topologically associating domains (TADs). Genomic areas work together with nuclear lamina, termed lamina-associated domains (LADs). Nevertheless, the molecular mechanisms underlying these 3D chromatin architectures stay incompletely understood. Right here, we investigated the function of a possible tumor suppressor, TOP1 Binding Arginine/Serine Wealthy Protein (TOPORS), in genome group.

 

  • In mouse hepatocytes, chromatin interactions between A and B compartments enhance and compartmentalization power is lowered considerably upon Topors knockdown.

 

  • Correspondingly, power of TAD boundaries situated at A/B borders is weakened. Within the absence of TOPORS, chromatin-lamina interactions lower and the protection of LADs reduces from 53.31% to 46.52%. Apparently, these adjustments in 3D genome are related to PML nuclear our bodies and PML-associated domains (PADs).

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment

  • Furthermore, chromatin accessibility is altered predominantly at intergenic regions upon Topors knockdown, together with a subset of enhancers.

 

  • These alterations of chromatin are concordant with transcriptome adjustments, that are related to carcinogenesis. Collectively, our findings demonstrate that TOPORS features as a regulator in chromatin construction, offering novel perception into the architectural roles of tumor suppressors in higher-order genome organization.

 

 

 

Human Von Hippel-Lindau disease tumor suppressor (VHL) ELISA Kit
AE11684HU-48T 48T
EUR 325

Human Von Hippel-Lindau disease tumor suppressor (VHL) ELISA Kit
AE11684HU-48Tests 48 Tests
EUR 325

Human Von Hippel-Lindau disease tumor suppressor (VHL) ELISA Kit
AE11684HU-96T 96T
EUR 610

Human Von Hippel-Lindau disease tumor suppressor (VHL) ELISA Kit
AE11684HU-96Tests 96 Tests
EUR 610

Human Von Hippel-Lindau disease tumor suppressor,VHL ELISA KIT
E6401Hu-1096T 10*96T
EUR 4122

Human Von Hippel-Lindau disease tumor suppressor,VHL ELISA KIT
E6401Hu-48wells 48 wells
EUR 300

Human Von Hippel-Lindau disease tumor suppressor,VHL ELISA KIT
E6401Hu-596T 5*96T
EUR 2061

Human Von Hippel-Lindau disease tumor suppressor,VHL ELISA KIT
E6401Hu-96wells 96 wells
EUR 458

Human Von Hippel-Lindau disease tumor suppressor,VHL ELISA KIT
JOT-EK6401Hu 96 wells Ask for price

Human Von Hippel-Lindau disease tumor suppressor, VHL ELISA Kit
MBS1607245-10x96StripWells 10x96-Strip-Wells
EUR 3460

Human Von Hippel-Lindau disease tumor suppressor, VHL ELISA Kit
MBS1607245-48StripWells 48-Strip-Wells
EUR 285

Human Von Hippel-Lindau disease tumor suppressor, VHL ELISA Kit
MBS1607245-5x96StripWells 5x96-Strip-Wells
EUR 1750

Human Von Hippel-Lindau disease tumor suppressor, VHL ELISA Kit
MBS1607245-96StripWells 96-Strip-Wells
EUR 425

Human Von Hippel-Lindau disease tumor suppressor (VHL) ELISA Kit
RK12330 96T
EUR 322.37

ELISA Kit for Von Hippel Lindau Tumor Suppressor (vHL)
SEJ769Ra 96Т
EUR 760

Human VHL(Von Hippel-Lindau disease tumor suppressor) ELISA Kit
EH1986 96T
EUR 681.12

Human VHL/ Von Hippel-Lindau disease tumor suppressor ELISA Kit
E2661Hu 1 Kit
EUR 515

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
DL-vHL-Hu 96T
EUR 475

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
EKL61493-5x96T 5x96T
EUR 4085.95

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
EKL61493-96T 96T
EUR 860.2

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
EK17268 96Т
EUR 768

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
DLR-vHL-Hu 96T
EUR 499

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
DLR-vHL-Hu-48T 48T
EUR 658.8

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
DLR-vHL-Hu-96T 96T
EUR 861.6

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
MBS456166-10x96StripWells 10x96-Strip-Wells
EUR 5375

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
MBS456166-48StripWells 48-Strip-Wells
EUR 470

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
MBS456166-5x96StripWells 5x96-Strip-Wells
EUR 2760

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
MBS456166-96StripWells 96-Strip-Wells
EUR 620

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
MBS4503326-10x96Tests 10x96Tests
EUR 5615

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
MBS4503326-48Tests 48Tests
EUR 485

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
MBS4503326-5x96Tests 5x96Tests
EUR 2875

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
MBS4503326-96Test 96Test
EUR 645

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Hu-48T 48T
EUR 537

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Hu-48Tests 48 Tests
EUR 699.6

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Hu-96T 96T
EUR 768

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Hu-96Tests 96 Tests
EUR 973.2

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Hu-48T 48T
EUR 512

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Hu-48Tests 48 Tests
EUR 668.4

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Hu-96T 96T
EUR 731

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Hu-96Tests 96 Tests
EUR 930

Human Von Hippel-Lindau disease Tumor suppressor, VHL GENLISA ELISA
KBH6401 1 x 96 wells
EUR 286

Rat Von Hippel-Lindau disease tumor suppressor (VHL) ELISA Kit
AE11682RA-48T 48T
EUR 325

Rat Von Hippel-Lindau disease tumor suppressor (VHL) ELISA Kit
AE11682RA-96T 96T
EUR 610

Dog Von Hippel-Lindau disease tumor suppressor, VHL ELISA Kit
MBS9334099-10x96StripWells 10x96-Strip-Wells
EUR 6725

Dog Von Hippel-Lindau disease tumor suppressor, VHL ELISA Kit
MBS9334099-48StripWells 48-Strip-Wells
EUR 550

Dog Von Hippel-Lindau disease tumor suppressor, VHL ELISA Kit
MBS9334099-5x96StripWells 5x96-Strip-Wells
EUR 3420

Dog Von Hippel-Lindau disease tumor suppressor, VHL ELISA Kit
MBS9334099-96StripWells 96-Strip-Wells
EUR 765

Rat Von Hippel-Lindau disease tumor suppressor (VHL) ELISA Kit
RK14919 96T
EUR 322.37

Human vHL (Von Hippel Lindau Tumor Suppressor) ELISA Kit
MBS8819815-10x96StripWells 10x96-Strip-Wells
EUR 3130

Human vHL (Von Hippel Lindau Tumor Suppressor) ELISA Kit
MBS8819815-48StripWells 48-Strip-Wells
EUR 350

Human vHL (Von Hippel Lindau Tumor Suppressor) ELISA Kit
MBS8819815-5x96StripWells 5x96-Strip-Wells
EUR 1710

Human vHL (Von Hippel Lindau Tumor Suppressor) ELISA Kit
MBS8819815-96StripWells 96-Strip-Wells
EUR 445

ELISA kit for Rat vHL (Von Hippel Lindau Tumor Suppressor)
ELK6800 1 plate of 96 wells
EUR 518.4

Mouse Von Hippel-Lindau disease tumor suppressor (VHL) ELISA Kit
AE11683MO-48T 48T
EUR 305

Mouse Von Hippel-Lindau disease tumor suppressor (VHL) ELISA Kit
AE11683MO-96T 96T
EUR 610

Mouse Von Hippel-Lindau disease tumor suppressor, VHL ELISA Kit
MBS9328482-10x96StripWells 10x96-Strip-Wells
EUR 6725

Mouse Von Hippel-Lindau disease tumor suppressor, VHL ELISA Kit
MBS9328482-48StripWells 48-Strip-Wells
EUR 550

Mouse Von Hippel-Lindau disease tumor suppressor, VHL ELISA Kit
MBS9328482-5x96StripWells 5x96-Strip-Wells
EUR 3420

Mouse Von Hippel-Lindau disease tumor suppressor, VHL ELISA Kit
MBS9328482-96StripWells 96-Strip-Wells
EUR 765

Mouse Von Hippel-Lindau disease tumor suppressor (VHL) ELISA Kit
RK13981 96T
EUR 322.37

Recombinant Human Von Hippel-Lindau disease tumor suppressor(VHL)
AP77730 1mg
EUR 2826

Recombinant Human Von Hippel-Lindau disease tumor suppressor (VHL)
CSB-EP025852HU 2480 mg Ask for price

Recombinant Human Von Hippel-Lindau disease tumor suppressor (VHL)
CSB-EP025852HU-20ug 20ug Ask for price

Recombinant Human Von Hippel-Lindau disease tumor suppressor (VHL)
MBS962022-002mgEColi 0.02mg(E-Coli)
EUR 320

Recombinant Human Von Hippel-Lindau disease tumor suppressor (VHL)
MBS962022-01mgEColi 0.1mg(E-Coli)
EUR 520

Recombinant Human Von Hippel-Lindau disease tumor suppressor (VHL)
MBS962022-1mgEColi 1mg(E-Coli)
EUR 1925

Recombinant Human Von Hippel-Lindau disease tumor suppressor (VHL)
MBS962022-5x1mgEColi 5x1mg(E-Coli)
EUR 8405

Recombinant Human Von Hippel-Lindau disease tumor suppressor (VHL)
RPC22221-100ug 100ug
EUR 572

Recombinant Human Von Hippel-Lindau disease tumor suppressor (VHL)
RPC22221-1mg 1mg
EUR 2884.7

Recombinant Human Von Hippel-Lindau disease tumor suppressor (VHL)
RPC22221-20ug 20ug
EUR 353.4

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Protein
abx260439-10g 10 µg
EUR 325

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Protein
20-abx260439
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 ug
  • 50 ug
  • 1 mg

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Protein
abx260439-2g 2 µg
EUR 225

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx137392-01mg 0.1 mg
EUR 225

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
20-abx137392
  • Ask for price
  • Ask for price
  • Ask for price
  • 5 ug
  • 20 ug
  • 100 ug

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx137707-100tests 100 tests
EUR 225

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx125410-50ul 50 ul
EUR 427.2

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx126781-100l 100 µl
EUR 175

 

  • The gene encoding ‘deleted in breast most cancers 2’ (DBC2), additionally known as RHOBTB2 (Rho-related BTB domain-containing protein 2), is assessed as a tumor suppressor gene. DBC2 is a substrate-specific adaptor protein for a novel class of Cullin-3 (CUL3)-based E3 ubiquitin ligases; nonetheless, it’s unclear if the substrate adaptor operate of DBC2 is required for its tumor suppressor exercise. Moreover, the important thing substrates of DBC2-mediated ubiquitination have but to be recognized.

 

  • Within the current research, we established a genome-wide human cDNA library-based in vitro ubiquitination goal screening assay and recognized Musashi-2 (MSI2) as a novel ubiquitination goal protein of DBC2. MSI2 immediately interacted with DBC2, and this interplay promoted MSI2 polyubiquitination and proteasomal degradation in breast most cancers cells.

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment

  • Overexpression and knockdown experiments demonstrated that DBC2 suppressed MSI2-associated oncogenic features and induced apoptosis.

 

  • Immunohistochemistry evaluation of a breast most cancers tissue microarray revealed that DBC2 and MSI2 protein ranges are inversely correlated in each regular breast tissues and breast most cancers tissues. Taken collectively, these findings present proof that DBC2 suppresses tumorigenesis in breast most cancers by ubiquitinating MSI2.

Fhit, a tumor suppressor protein, induces autophagy via 14-3-3τ in non-small cell lung most cancers cells.

 

 

Von Hippel-Lindau Illness Tumor Suppressor (VHL) Antibody

 

 

Inactivation of the delicate histidine triad (Fhit) gene has been reported within the majority of human cancers, significantly in lung most cancers.

 

The function of Fhit as a tumor suppressor gene has been nicely documented, and restoration of Fhit expression suppresses tumorigenicity in tumor cell traces and in mouse fashions by inducing apoptosis and inhibiting proliferation of tumor cells.

 

Autophagy is a catabolic pathway, whereby cytoplasmic proteins and organelles are sequestered in vacuoles and delivered to lysosomes for degradation and recycling.

 

 

VHL Polyclonal Antibody
E-AB-65684-60uL 60uL
EUR 200

VHL Polyclonal Antibody
E-AB-65684-each each Ask for price

VHL Polyclonal Antibody
E20-74876 100ug
EUR 225

VHL Polyclonal Antibody
E046866 100μg/100μl
EUR 255

VHL Polyclonal Antibody
46866 100ul
EUR 319

VHL Polyclonal Antibody
46866-100ul 100ul
EUR 302.4

VHL Polyclonal Antibody
46866-50ul 50ul
EUR 224.4

VHL Polyclonal Antibody
ABP60891-003ml 0.03ml
EUR 189.6

VHL Polyclonal Antibody
ABP60891-01ml 0.1ml
EUR 346.8

VHL Polyclonal Antibody
ABP60891-02ml 0.2ml
EUR 496.8

VHL Polyclonal Antibody
BT-AP09520-100ul 100ul Ask for price

VHL Polyclonal Antibody
BT-AP09520-20ul 20ul Ask for price

VHL Polyclonal Antibody
BT-AP09520-50ul 50ul Ask for price

VHL polyclonal antibody
BS60046 50ul
EUR 275

VHL polyclonal antibody
BS6051 50 ul
EUR 358

VHL polyclonal antibody
BS79552 50ul
EUR 358

VHL polyclonal antibody
BS79628 50ul
EUR 358

VHL Polyclonal Antibody
BT-AP15472-100ul 100ul Ask for price

VHL Polyclonal Antibody
BT-AP15472-20ul 20ul Ask for price

VHL Polyclonal Antibody
BT-AP15472-50ul 50ul Ask for price

VHL Polyclonal Antibody
E911240 100ul
EUR 225

VHL Polyclonal Antibody
E916287 100ul
EUR 225

VHL Polyclonal Antibody
E44H06396 100ul
EUR 255

VHL Polyclonal Antibody
E44H07430 100ul
EUR 255

VHL Polyclonal Antibody
JOT-AP09520-100ul 100ul
EUR 220

VHL Polyclonal Antibody
JOT-AP09520-50ul 50ul
EUR 144

VHL Polyclonal Antibody
JOT-AP15472-100ul 100ul
EUR 220

VHL Polyclonal Antibody
JOT-AP15472-50ul 50ul
EUR 144

VHL Polyclonal Antibody
E-AB-66748-120uL 120uL
EUR 320

VHL Polyclonal Antibody
E-AB-66748-200uL 200uL
EUR 530

VHL Polyclonal Antibody
E-AB-66748-60uL 60uL
EUR 200

VHL Polyclonal Antibody
E-AB-66748-each each Ask for price

VHL Polyclonal Antibody
E-AB-93053-120uL 120uL
EUR 320

VHL Polyclonal Antibody
E-AB-93053-200uL 200uL
EUR 530

VHL Polyclonal Antibody
E-AB-93053-60uL 60uL
EUR 200

VHL Polyclonal Antibody
E-AB-93053-each each Ask for price

VHL Polyclonal Antibody
MBS125962-002mL 0.02mL
EUR 200

VHL Polyclonal Antibody
MBS125962-005mL 0.05mL
EUR 255

VHL Polyclonal Antibody
MBS125962-01mL 0.1mL
EUR 345

VHL Polyclonal Antibody
MBS125962-02mL 0.2mL
EUR 545

VHL Polyclonal Antibody
MBS125962-5x02mL 5x0.2mL
EUR 2265

VHL Polyclonal Antibody
MBS2522130-002mL 0.02mL
EUR 135

VHL Polyclonal Antibody
MBS2522130-006mL 0.06mL
EUR 190

VHL Polyclonal Antibody
MBS2522130-012mL 0.12mL
EUR 265

VHL Polyclonal Antibody
MBS2522130-02mL 0.2mL
EUR 415

VHL Polyclonal Antibody
MBS2522130-5x02mL 5x0.2mL
EUR 1835

VHL Polyclonal Antibody
MBS2522353-002mL 0.02mL
EUR 140

VHL Polyclonal Antibody
MBS2522353-006mL 0.06mL
EUR 180

VHL Polyclonal Antibody
MBS2522353-012mL 0.12mL
EUR 260

VHL Polyclonal Antibody
MBS2522353-02mL 0.2mL
EUR 405

VHL Polyclonal Antibody
MBS2522353-5x02mL 5x0.2mL
EUR 1725

VHL Polyclonal Antibody
MBS2549660-002mL 0.02mL
EUR 140

VHL Polyclonal Antibody
MBS2549660-006mL 0.06mL
EUR 180

VHL Polyclonal Antibody
MBS2549660-012mL 0.12mL
EUR 260

VHL Polyclonal Antibody
MBS2549660-02mL 0.2mL
EUR 405

VHL Polyclonal Antibody
MBS2565580-006mL 0.06mL
EUR 190

VHL Polyclonal Antibody
MBS2565580-012mL 0.12mL
EUR 265

VHL Polyclonal Antibody
MBS2565580-02mL 0.2mL
EUR 415

VHL Polyclonal Antibody
MBS2565580-5x02mL 5x0.2mL
EUR 1835

VHL Polyclonal Antibody
MBS2564516-006mL 0.06mL
EUR 190

VHL Polyclonal Antibody
MBS2564516-012mL 0.12mL
EUR 265

VHL Polyclonal Antibody
MBS2564516-02mL 0.2mL
EUR 415

VHL Polyclonal Antibody
MBS2564516-5x02mL 5x0.2mL
EUR 1835

VHL Polyclonal Antibody
MBS8566819-01mL 0.1mL
EUR 305

VHL Polyclonal Antibody
MBS8566819-01mLAF405L 0.1mL(AF405L)
EUR 565

VHL Polyclonal Antibody
MBS8566819-01mLAF405S 0.1mL(AF405S)
EUR 565

VHL Polyclonal Antibody
MBS8566819-01mLAF610 0.1mL(AF610)
EUR 565

VHL Polyclonal Antibody
MBS8566819-01mLAF635 0.1mL(AF635)
EUR 565

VHL Polyclonal Antibody
MBS8532574-01mg 0.1mg
EUR 305

VHL Polyclonal Antibody
MBS8532574-01mLAF405L 0.1mL(AF405L)
EUR 465

VHL Polyclonal Antibody
MBS8532574-01mLAF405S 0.1mL(AF405S)
EUR 465

VHL Polyclonal Antibody
MBS8532574-01mLAF610 0.1mL(AF610)
EUR 465

VHL Polyclonal Antibody
MBS8532574-01mLAF635 0.1mL(AF635)
EUR 465

VHL Polyclonal Antibody
MBS8525857-01mg 0.1mg
EUR 305

VHL Polyclonal Antibody
MBS8525857-01mLAF405L 0.1mL(AF405L)
EUR 465

VHL Polyclonal Antibody
MBS8525857-01mLAF405S 0.1mL(AF405S)
EUR 465

VHL Polyclonal Antibody
MBS8525857-01mLAF610 0.1mL(AF610)
EUR 465

VHL Polyclonal Antibody
MBS8525857-01mLAF635 0.1mL(AF635)
EUR 465

VHL Polyclonal Antibody
MBS9131396-002mL 0.02mL
EUR 200

VHL Polyclonal Antibody
MBS9131396-005mL 0.05mL
EUR 255

VHL Polyclonal Antibody
MBS9131396-01mL 0.1mL
EUR 345

VHL Polyclonal Antibody
MBS9131396-02mL 0.2mL
EUR 545

VHL Polyclonal Antibody
MBS9131396-5x02mL 5x0.2mL
EUR 2265

VHL Polyclonal Antibody
MBS9246598-01mL 0.1mL
EUR 415

VHL Polyclonal Antibody
MBS9246598-5x01mL 5x0.1mL
EUR 1841

VHL Polyclonal Antibody
MBS9419851-005mL 0.05mL
EUR 245

VHL Polyclonal Antibody
MBS9419851-01mL 0.1mL
EUR 305

VHL Polyclonal Antibody
MBS9419851-5x01mL 5x0.1mL
EUR 1230

 

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment

Though autophagy is critical for cell survival underneath stress circumstances, latest research have proven that autophagy can even promote cell demise. On account of the truth that each autophagy induction and Fhit expression are generally related to nutrient hunger, we hypothesized that Fhit expression could also be associated to autophagy induction.

 

 

Within the current research, we assessed whether or not Fhit overexpression by gene switch induces autophagy in Fhit-deficient non-small cell lung most cancers (NSCLC) cells. The outcomes of our research point out that Fhit protein induces autophagy in NSCLC cells, and that this autophagy prevents apoptotic cell demise in vivo and in vitro in a 14-3-3τ protein-dependent method. To the perfect of our information, that is the primary report to explain Fhit-induced autophagy. Suppressing autophagy could be a promising therapeutic possibility to reinforce the efficacy of Fhit gene remedy in NSCLC.

Ronald

Leave A Comment