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Best tumor suppressor protein

TOPORS, a tumor suppressor protein, contributes to the maintenance of higher-order chromatin architecture.

 

  • Within the nucleus, chromosomes are hierarchically folded into lively (A) and inactive (B) compartments composed of topologically associating domains (TADs). Genomic areas work together with nuclear lamina, termed lamina-associated domains (LADs). Nevertheless, the molecular mechanisms underlying these 3D chromatin architectures stay incompletely understood. Right here, we investigated the function of a possible tumor suppressor, TOP1 Binding Arginine/Serine Wealthy Protein (TOPORS), in genome group.

 

  • In mouse hepatocytes, chromatin interactions between A and B compartments enhance and compartmentalization power is lowered considerably upon Topors knockdown.

 

  • Correspondingly, power of TAD boundaries situated at A/B borders is weakened. Within the absence of TOPORS, chromatin-lamina interactions lower and the protection of LADs reduces from 53.31% to 46.52%. Apparently, these adjustments in 3D genome are related to PML nuclear our bodies and PML-associated domains (PADs).

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment

  • Furthermore, chromatin accessibility is altered predominantly at intergenic regions upon Topors knockdown, together with a subset of enhancers.

 

  • These alterations of chromatin are concordant with transcriptome adjustments, that are related to carcinogenesis. Collectively, our findings demonstrate that TOPORS features as a regulator in chromatin construction, offering novel perception into the architectural roles of tumor suppressors in higher-order genome organization.

 

 

 

Human VHL/ Von Hippel-Lindau disease tumor suppressor ELISA Kit
E2661Hu 1 Kit
EUR 685.2

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Protein
20-abx260439
  • EUR 276.00
  • EUR 2798.40
  • EUR 393.60
  • 10 ug
  • 1 mg
  • 50 ug

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
20-abx137392
  • EUR 844.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 20 ug
  • 5 ug

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx239402-100ug 100 ug
EUR 610.8

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx219331-100ug 100 ug
EUR 526.8

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx117007-100ug 100 ug
EUR 560.4

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx032864-400ul 400 ul
EUR 627.6

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx032864-80l 80 µl
EUR 343.2

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx032865-400ul 400 ul
EUR 627.6

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx032865-80l 80 µl
EUR 343.2

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
20-abx126781
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx125410-50ul 50 ul
EUR 427.2

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx431703-200ul 200 ul
EUR 460.8

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
20-abx000699
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx012353-100ug 100 ug
EUR 526.8

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
DLR-vHL-Hu-48T 48T
EUR 658.8

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
DLR-vHL-Hu-96T 96T
EUR 861.6

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Hu-48Tests 48 Tests
EUR 668.4

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Hu-96Tests 96 Tests
EUR 930

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Hu-48Tests 48 Tests
EUR 699.6

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Hu-96Tests 96 Tests
EUR 973.2

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Hu-48T 48T
EUR 512.09

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Hu-96T 96T
EUR 731.54

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Hu-48T 48T
EUR 487.7

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Hu-96T 96T
EUR 696.7

ELISA kit for Rat vHL (Von Hippel Lindau Tumor Suppressor)
ELK6800 1 plate of 96 wells
EUR 518.4

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
DLR-vHL-Ra-48T 48T
EUR 658.8

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
DLR-vHL-Ra-96T 96T
EUR 861.6

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
SEJ769Ra-10x96wellstestplate 10x96-wells test plate
EUR 6149.04

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
SEJ769Ra-1x48wellstestplate 1x48-wells test plate
EUR 611.57

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
SEJ769Ra-1x96wellstestplate 1x96-wells test plate
EUR 822.24

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
SEJ769Ra-5x96wellstestplate 5x96-wells test plate
EUR 3340.08

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Ra-48Tests 48 Tests
EUR 668.4

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Ra-96Tests 96 Tests
EUR 930

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Ra-48Tests 48 Tests
EUR 699.6

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Ra-96Tests 96 Tests
EUR 973.2

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
4-SEJ769Ra
  • EUR 6210.00
  • EUR 3280.80
  • EUR 823.20
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Ra-48T 48T
EUR 512.09

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Ra-96T 96T
EUR 731.54

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Ra-48T 48T
EUR 487.7

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Ra-96T 96T
EUR 696.7

ELISA kit for Human Von Hippel-Lindau disease tumor suppressor
EK4060 96 tests
EUR 663.6

Von Hippel Lindau Tumor Suppressor (VHL) Antibody
20-abx210322
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Von Hippel Lindau Tumor Suppressor (vHL) Antibody
20-abx175113
  • EUR 1095.60
  • EUR 560.40
  • 1 mg
  • 200 ug

Von Hippel Lindau Tumor Suppressor (VHL) Antibody
20-abx211119
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Von Hippel Lindau Tumor Suppressor (VHL) Antibody
20-abx326550
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Von Hippel Lindau Tumor Suppressor (vHL) Antibody
20-abx131162
  • EUR 543.60
  • EUR 159.60
  • EUR 1562.40
  • EUR 744.00
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Von Hippel Lindau Tumor Suppressor (VHL) Antibody
20-abx323201
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody (Biotin)
abx431704-200ul 200 ul
EUR 460.8

Recombinant Von Hippel Lindau Tumor Suppressor (vHL)
4-RPJ769Ra01
  • EUR 614.59
  • EUR 288.00
  • EUR 1974.72
  • EUR 738.24
  • EUR 1356.48
  • EUR 487.20
  • EUR 4756.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg

Rat Von Hippel Lindau Tumor Suppressor (vHL) CLIA Kit
20-abx495777
  • EUR 10282.80
  • EUR 5472.00
  • EUR 1262.40
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rat Von Hippel Lindau Tumor Suppressor (vHL) Protein
20-abx650771
  • EUR 861.60
  • EUR 343.20
  • EUR 2665.20
  • EUR 1028.40
  • EUR 610.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Dog Von Hippel-Lindau disease tumor suppressor (pVHL) ELISA Kit
abx518740-96tests 96 tests
EUR 1093.2

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat)
4-PAJ769Ra01
  • EUR 310.80
  • EUR 3249.60
  • EUR 804.00
  • EUR 393.60
  • EUR 262.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Mouse Von Hippel Lindau Tumor Suppressor ELISA Kit
ELA-E1894m 96 Tests
EUR 1038

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), PE
4-PAJ769Ra01-PE
  • EUR 373.20
  • EUR 3427.20
  • EUR 964.80
  • EUR 471.60
  • EUR 242.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), APC
4-PAJ769Ra01-APC
  • EUR 436.80
  • EUR 4254.00
  • EUR 1176.00
  • EUR 560.40
  • EUR 272.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), Cy3
4-PAJ769Ra01-Cy3
  • EUR 532.80
  • EUR 5622.00
  • EUR 1518.00
  • EUR 697.20
  • EUR 313.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), HRP
4-PAJ769Ra01-HRP
  • EUR 398.40
  • EUR 3706.80
  • EUR 1039.20
  • EUR 505.20
  • EUR 255.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), FITC
4-PAJ769Ra01-FITC
  • EUR 373.20
  • EUR 3427.20
  • EUR 964.80
  • EUR 471.60
  • EUR 242.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor Phospho-Ser68 (VHL pS68) Antibody
20-abx326675
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), APC-Cy7
4-PAJ769Ra01-APC-Cy7
  • EUR 729.60
  • EUR 8364.00
  • EUR 2208.00
  • EUR 976.80
  • EUR 402.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), Biotinylated
4-PAJ769Ra01-Biotin
  • EUR 390.00
  • EUR 3189.60
  • EUR 932.40
  • EUR 480.00
  • EUR 270.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Human Von Hippel-Lindau Tumor Suppressor (VHL) ELISA Kit
abx251310-96tests 96 tests
EUR 895.2

Human Von Hippel-Lindau Tumor Suppressor (VHL) ELISA Kit
abx576631-96tests 96 tests
EUR 801.6

Rat Von Hippel-Lindau Tumor Suppressor (VHL) ELISA Kit
abx572904-96tests 96 tests
EUR 801.6

Rat Von Hippel-Lindau Tumor Suppressor (VHL) ELISA Kit
20-abx156227
  • EUR 8684.40
  • EUR 4626.00
  • EUR 1074.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Von Hippel-Lindau Tumor Suppressor (VHL) ELISA Kit
abx518742-96tests 96 tests
EUR 801.6

Human Von Hippel- Lindau- like protein, VHLL ELISA KIT
ELI-16884h 96 Tests
EUR 988.8

Polyclonal VHL / Von Hippel Lindau Antibody (aa34-83)
APR10721G 0.05ml
EUR 580.8

Von Hippel Lindau antibody
70R-50541 100 ul
EUR 292.8

Von Hippel Lindau Antibody
20-abx008579
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Monoclonal VHL / Von Hippel Lindau Antibody (clone 52A11), Clone: 52A11
APR10722G 0.05mg
EUR 580.8

Von Hippel Lindau Blocking Peptide
20-abx063416
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

PROTAC Optimization Kit for BET Bromodomain-Von Hippel Lindau (VHL) Binding
79790 384 rxns.
EUR 860

anti-Von Hippel Lindau
YF-PA24955 50 ul
EUR 400.8

anti-Von Hippel Lindau
YF-PA15270 50 ul
EUR 435.6

anti-Von Hippel Lindau
YF-PA15271 50 ug
EUR 435.6

 

  • The gene encoding ‘deleted in breast most cancers 2’ (DBC2), additionally known as RHOBTB2 (Rho-related BTB domain-containing protein 2), is assessed as a tumor suppressor gene. DBC2 is a substrate-specific adaptor protein for a novel class of Cullin-3 (CUL3)-based E3 ubiquitin ligases; nonetheless, it’s unclear if the substrate adaptor operate of DBC2 is required for its tumor suppressor exercise. Moreover, the important thing substrates of DBC2-mediated ubiquitination have but to be recognized.

 

  • Within the current research, we established a genome-wide human cDNA library-based in vitro ubiquitination goal screening assay and recognized Musashi-2 (MSI2) as a novel ubiquitination goal protein of DBC2. MSI2 immediately interacted with DBC2, and this interplay promoted MSI2 polyubiquitination and proteasomal degradation in breast most cancers cells.

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment

  • Overexpression and knockdown experiments demonstrated that DBC2 suppressed MSI2-associated oncogenic features and induced apoptosis.

 

  • Immunohistochemistry evaluation of a breast most cancers tissue microarray revealed that DBC2 and MSI2 protein ranges are inversely correlated in each regular breast tissues and breast most cancers tissues. Taken collectively, these findings present proof that DBC2 suppresses tumorigenesis in breast most cancers by ubiquitinating MSI2.

Fhit, a tumor suppressor protein, induces autophagy via 14-3-3τ in non-small cell lung most cancers cells.

 

 

Von Hippel-Lindau Illness Tumor Suppressor (VHL) Antibody

 

 

Inactivation of the delicate histidine triad (Fhit) gene has been reported within the majority of human cancers, significantly in lung most cancers.

 

The function of Fhit as a tumor suppressor gene has been nicely documented, and restoration of Fhit expression suppresses tumorigenicity in tumor cell traces and in mouse fashions by inducing apoptosis and inhibiting proliferation of tumor cells.

 

Autophagy is a catabolic pathway, whereby cytoplasmic proteins and organelles are sequestered in vacuoles and delivered to lysosomes for degradation and recycling.

 

 

VHL Polyclonal Antibody
ABP60891-01ml 0.1ml
EUR 346.8

VHL Polyclonal Antibody
ABP60891-02ml 0.2ml
EUR 496.8

VHL Polyclonal Antibody
ES7499-100ul 100ul
EUR 334.8

VHL Polyclonal Antibody
ES7499-50ul 50ul
EUR 248.4

VHL Polyclonal Antibody
ES8746-100ul 100ul
EUR 334.8

VHL Polyclonal Antibody
ES8746-50ul 50ul
EUR 248.4

Polyclonal VHL Antibody (C-term)
APR10723G 0.1ml
EUR 580.8

VHL (phospho Ser68) Polyclonal Antibody
ABP56499-003ml 0.03ml
EUR 189.6

VHL (phospho Ser68) Polyclonal Antibody
ABP56499-01ml 0.1ml
EUR 346.8

VHL (phospho Ser68) Polyclonal Antibody
ABP56499-02ml 0.2ml
EUR 496.8

VHL (phospho Ser68) Polyclonal Antibody
ES7498-100ul 100ul
EUR 334.8

VHL (phospho Ser68) Polyclonal Antibody
ES7498-50ul 50ul
EUR 248.4

VHL (Phospho-Ser68) Polyclonal Conjugated Antibody
C12654 100ul
EUR 476.4

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat)
4-PAJ769Ra01
  • EUR 310.80
  • EUR 3249.60
  • EUR 804.00
  • EUR 393.60
  • EUR 262.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), PE
4-PAJ769Ra01-PE
  • EUR 373.20
  • EUR 3427.20
  • EUR 964.80
  • EUR 471.60
  • EUR 242.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), APC
4-PAJ769Ra01-APC
  • EUR 436.80
  • EUR 4254.00
  • EUR 1176.00
  • EUR 560.40
  • EUR 272.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), Cy3
4-PAJ769Ra01-Cy3
  • EUR 532.80
  • EUR 5622.00
  • EUR 1518.00
  • EUR 697.20
  • EUR 313.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), HRP
4-PAJ769Ra01-HRP
  • EUR 398.40
  • EUR 3706.80
  • EUR 1039.20
  • EUR 505.20
  • EUR 255.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Polyclonal VHL / Von Hippel Lindau Antibody (aa34-83)
APR10721G 0.05ml
EUR 580.8

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), FITC
4-PAJ769Ra01-FITC
  • EUR 373.20
  • EUR 3427.20
  • EUR 964.80
  • EUR 471.60
  • EUR 242.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), Biotinylated
4-PAJ769Ra01-Biotin
  • EUR 390.00
  • EUR 3189.60
  • EUR 932.40
  • EUR 480.00
  • EUR 270.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), APC-Cy7
4-PAJ769Ra01-APC-Cy7
  • EUR 729.60
  • EUR 8364.00
  • EUR 2208.00
  • EUR 976.80
  • EUR 402.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Polyclonal Goat Anti-VHL Antibody
AMM05157G 0.1 mg
EUR 580.8

VHLL Polyclonal Antibody
A65646
  • EUR 684.66
  • EUR 117.70
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

VHLL Polyclonal Antibody, HRP Conjugated
A65647
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

VHLL Polyclonal Antibody, FITC Conjugated
A65648
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

VHLL Polyclonal Antibody, Biotin Conjugated
A65649
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

Polyclonal AntibodyP2 Polyclonal Antibody
ES10016-100ul 100ul
EUR 334.8

Polyclonal AntibodyP2 Polyclonal Antibody
ES10016-50ul 50ul
EUR 248.4

Polyclonal AntibodyP4 Polyclonal Antibody
ES10017-100ul 100ul
EUR 334.8

Polyclonal AntibodyP4 Polyclonal Antibody
ES10017-50ul 50ul
EUR 248.4

Polyclonal AntibodyP5 Polyclonal Antibody
ES4829-100ul 100ul
EUR 334.8

Polyclonal AntibodyP5 Polyclonal Antibody
ES4829-50ul 50ul
EUR 248.4

Polyclonal AntibodyP1 Polyclonal Antibody
ES11752-100ul 100ul
EUR 334.8

Polyclonal AntibodyP1 Polyclonal Antibody
ES11752-50ul 50ul
EUR 248.4

Polyclonal AntibodyP3 Polyclonal Antibody
ES6454-100ul 100ul
EUR 334.8

Polyclonal AntibodyP3 Polyclonal Antibody
ES6454-50ul 50ul
EUR 248.4

Polyclonal PML polyclonal antibody
AMR09397G 0.05mg
EUR 580.8

Polyclonal YY1 polyclonal antibody
APR14018G 0.1ml
EUR 580.8

Polyclonal ETO polyclonal antibody
APR00372G 0.05ml
EUR 580.8

Polyclonal SHH Polyclonal Antibody
APR00434G 0.1mg
EUR 580.8

Polyclonal ETO polyclonal antibody
APR00435G 0.1ml
EUR 633.6

Polyclonal p53 polyclonal antibody
APR00443G 0.05mg
EUR 633.6

Polyclonal G9a polyclonal antibody
APR00448G 0.1ml
EUR 580.8

Polyclonal Rtf1 polyclonal antibody
APR11187G 0.05mg
EUR 633.6

Polyclonal Rtf1 polyclonal antibody
APR11188G 0.1ml
EUR 633.6

Polyclonal SOX4 polyclonal antibody
APR13475G 0.1ml
EUR 580.8

Polyclonal RARA polyclonal antibody
APR00370G 0.05ml
EUR 580.8

Polyclonal EzH2 polyclonal antibody
APR00373G 0.05mg
EUR 580.8

Polyclonal BRD2 polyclonal antibody
APR00374G 0.05ml
EUR 580.8

Polyclonal BMI1 polyclonal antibody
APR00376G 0.05ml
EUR 580.8

Polyclonal EZH2 polyclonal antibody
APR00436G 0.1ml
EUR 633.6

Polyclonal RARA polyclonal antibody
APR00437G 0.1ml
EUR 633.6

Polyclonal EZH2 polyclonal antibody
APR00439G 0.05mg
EUR 633.6

Polyclonal CHD4 polyclonal antibody
APR00444G 0.1ml
EUR 580.8

Polyclonal BRD2 polyclonal antibody
APR00447G 0.1ml
EUR 580.8

Polyclonal Hira polyclonal antibody
APR00449G 0.1ml
EUR 580.8

Polyclonal SPI1 polyclonal antibody
APR00451G 0.1ml
EUR 580.8

Polyclonal BMI1 polyclonal antibody
APR00457G 0.1ml
EUR 580.8

Polyclonal CHD4 polyclonal antibody
APR00459G 0.05mg
EUR 580.8

Polyclonal MeCP2 polyclonal antibody
AMM06350G 0.05mg
EUR 633.6

Polyclonal MeCP2 polyclonal antibody
AMM06351G 0.05mg
EUR 580.8

Polyclonal PPARG polyclonal antibody
AMR09459G 0.05mg
EUR 580.8

Polyclonal PPARG polyclonal antibody
AMR09486G 0.05mg
EUR 633.6

Polyclonal Med26 polyclonal antibody
APR12517G 0.05mg
EUR 580.8

Polyclonal Med26 polyclonal antibody
APR12518G 0.1ml
EUR 580.8

Polyclonal MeCP2 polyclonal antibody
APR12525G 0.1ml
EUR 580.8

Polyclonal MeCP2 polyclonal antibody
APR12526G 0.1ml
EUR 580.8

Polyclonal MeCP2 polyclonal antibody
APR12527G 0.05mg
EUR 633.6

Polyclonal PADI4 polyclonal antibody
APR08916G 0.1ml
EUR 580.8

Polyclonal MYH11 polyclonal antibody
APR00438G 0.1ml
EUR 633.6

Polyclonal CIITA polyclonal antibody
APR00442G 0.05mg
EUR 633.6

Polyclonal HDAC1 polyclonal antibody
APR00445G 0.1ml
EUR 580.8

Polyclonal Spt16 polyclonal antibody
APR00446G 0.1ml
EUR 580.8

Polyclonal BCL7C polyclonal antibody
APR00452G 0.1ml
EUR 580.8

Polyclonal LRWD1 polyclonal antibody
APR00455G 0.1ml
EUR 580.8

Polyclonal KDM4D polyclonal antibody
APR00458G 0.1ml
EUR 580.8

Polyclonal Spt16 polyclonal antibody
APR00460G 0.05mg
EUR 580.8

Polyclonal ACTL6B polyclonal antibody
AMM05547G 0.1ml
EUR 580.8

Polyclonal JARID2 polyclonal antibody
AMM06027G 0.05ml
EUR 580.8

Polyclonal ZMYND8 polyclonal antibody
AMM08559G 0.1ml
EUR 580.8

Polyclonal JARID2 polyclonal antibody
APR12450G 0.1ml
EUR 580.8

Polyclonal FKBP51 polyclonal antibody
APR15992G 0.1ml
EUR 580.8

Polyclonal PIWIL2 polyclonal antibody
APR17846G 0.1ml
EUR 580.8

Polyclonal JMJD2c polyclonal antibody
APR00375G 0.05ml
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Polyclonal JMJD2c polyclonal antibody
APR00450G 0.1ml
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Polyclonal LYDG10 polyclonal antibody
APR00456G 0.1ml
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Polyclonal AKR1B10 Polyclonal Antibody
APG01659G 0.1mg
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Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment

Though autophagy is critical for cell survival underneath stress circumstances, latest research have proven that autophagy can even promote cell demise. On account of the truth that each autophagy induction and Fhit expression are generally related to nutrient hunger, we hypothesized that Fhit expression could also be associated to autophagy induction.

 

 

Within the current research, we assessed whether or not Fhit overexpression by gene switch induces autophagy in Fhit-deficient non-small cell lung most cancers (NSCLC) cells. The outcomes of our research point out that Fhit protein induces autophagy in NSCLC cells, and that this autophagy prevents apoptotic cell demise in vivo and in vitro in a 14-3-3τ protein-dependent method. To the perfect of our information, that is the primary report to explain Fhit-induced autophagy. Suppressing autophagy could be a promising therapeutic possibility to reinforce the efficacy of Fhit gene remedy in NSCLC.

Ronald

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