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Best tumor suppressor protein

TOPORS, a tumor suppressor protein, contributes to the maintenance of higher-order chromatin architecture.

 

  • Within the nucleus, chromosomes are hierarchically folded into lively (A) and inactive (B) compartments composed of topologically associating domains (TADs). Genomic areas work together with nuclear lamina, termed lamina-associated domains (LADs). Nevertheless, the molecular mechanisms underlying these 3D chromatin architectures stay incompletely understood. Right here, we investigated the function of a possible tumor suppressor, TOP1 Binding Arginine/Serine Wealthy Protein (TOPORS), in genome group.

 

  • In mouse hepatocytes, chromatin interactions between A and B compartments enhance and compartmentalization power is lowered considerably upon Topors knockdown.

 

  • Correspondingly, power of TAD boundaries situated at A/B borders is weakened. Within the absence of TOPORS, chromatin-lamina interactions lower and the protection of LADs reduces from 53.31% to 46.52%. Apparently, these adjustments in 3D genome are related to PML nuclear our bodies and PML-associated domains (PADs).

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment

  • Furthermore, chromatin accessibility is altered predominantly at intergenic regions upon Topors knockdown, together with a subset of enhancers.

 

  • These alterations of chromatin are concordant with transcriptome adjustments, that are related to carcinogenesis. Collectively, our findings demonstrate that TOPORS features as a regulator in chromatin construction, offering novel perception into the architectural roles of tumor suppressors in higher-order genome organization.

 

 

 

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Hu-48Tests 48 Tests
EUR 583

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Hu-96Tests 96 Tests
EUR 811

Human Von Hippel-Lindau disease tumor suppressor (VHL)
1-CSB-EP025852HU
  • EUR 505.00
  • EUR 265.00
  • EUR 1827.00
  • EUR 766.00
  • EUR 1218.00
  • EUR 335.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Ra-48Tests 48 Tests
EUR 557

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Ra-96Tests 96 Tests
EUR 775

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
DLR-vHL-Ra-48T 48T
EUR 549

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
DLR-vHL-Ra-96T 96T
EUR 718

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Ra-48Tests 48 Tests
EUR 583

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Ra-96Tests 96 Tests
EUR 811

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx125410-50ul 50 ul
EUR 356

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
20-abx126781
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx117007-100ug 100 ug
EUR 467

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
20-abx137392
  • EUR 704.00
  • EUR 328.00
  • EUR 230.00
  • 100 ug
  • 20 ug
  • 5 ug

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
20-abx000699
  • EUR 411.00
  • EUR 592.00
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  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx012353-100ug 100 ug
EUR 439

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx032864-400ul 400 ul
EUR 523

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx032864-80l 80 µl
EUR 286

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abx032865-400ul 400 ul
EUR 523

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx032865-80l 80 µl
EUR 286

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx431703-200ul 200 ul
EUR 384

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Protein
20-abx260439
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  • EUR 2332.00
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  • 10 ug
  • 1 mg
  • 50 ug

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx239402-100ug 100 ug
EUR 509

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx219331-100ug 100 ug
EUR 439

Human VHL/ Von Hippel-Lindau disease tumor suppressor ELISA Kit
E2661Hu 1 Kit
EUR 571

Human VHL(Von Hippel-Lindau disease tumor suppressor) ELISA Kit
EH1986 96T
EUR 567.6

Human Von Hippel- Lindau disease tumor suppressor, VHL ELISA KIT
ELI-06082h 96 Tests
EUR 824

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody (Biotin)
abx431704-200ul 200 ul
EUR 384

Mouse Von Hippel- Lindau disease tumor suppressor, Vhl ELISA KIT
ELI-06081m 96 Tests
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Recombinant Von Hippel Lindau Tumor Suppressor (vHL)
4-RPJ769Ra01
  • EUR 512.16
  • EUR 240.00
  • EUR 1645.60
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  • EUR 1130.40
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg

Von Hippel Lindau Tumor Suppressor (vHL) Antibody
20-abx131162
  • EUR 453.00
  • EUR 133.00
  • EUR 1302.00
  • EUR 620.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Von Hippel Lindau Tumor Suppressor (VHL) Antibody
20-abx323201
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Von Hippel Lindau Tumor Suppressor (VHL) Antibody
20-abx210322
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Von Hippel Lindau Tumor Suppressor (VHL) Antibody
20-abx211119
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Von Hippel Lindau Tumor Suppressor (vHL) Antibody
20-abx175113
  • EUR 913.00
  • EUR 467.00
  • 1 mg
  • 200 ug

Von Hippel Lindau Tumor Suppressor (VHL) Antibody
20-abx326550
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Human Von Hippel-Lindau Tumor Suppressor (VHL) ELISA Kit
abx576631-96tests 96 tests
EUR 668

Human Von Hippel-Lindau Tumor Suppressor (VHL) ELISA Kit
abx251310-96tests 96 tests
EUR 746

ELISA kit for Rat vHL (Von Hippel Lindau Tumor Suppressor)
ELK6800 1 plate of 96 wells
EUR 432

ELISA kit for Human Von Hippel-Lindau disease tumor suppressor
EK4060 96 tests
EUR 553

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
SEJ769Ra-10x96wellstestplate 10x96-wells test plate
EUR 5124.2

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
SEJ769Ra-1x48wellstestplate 1x48-wells test plate
EUR 509.64

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
SEJ769Ra-1x96wellstestplate 1x96-wells test plate
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Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
SEJ769Ra-5x96wellstestplate 5x96-wells test plate
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Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
4-SEJ769Ra
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  • 10 plates of 96 wells
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  • 1 plate of 96 wells

Rat Von Hippel-Lindau Tumor Suppressor (VHL) ELISA Kit
abx572904-96tests 96 tests
EUR 668

Mouse Von Hippel-Lindau Tumor Suppressor (VHL) ELISA Kit
abx518742-96tests 96 tests
EUR 668

Rat Von Hippel-Lindau Tumor Suppressor (VHL) ELISA Kit
20-abx156227
  • EUR 7237.00
  • EUR 3855.00
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rat Von Hippel Lindau Tumor Suppressor (vHL) Protein
20-abx650771
  • EUR 718.00
  • EUR 286.00
  • EUR 2221.00
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rat Von Hippel Lindau Tumor Suppressor (vHL) CLIA Kit
20-abx495777
  • EUR 8569.00
  • EUR 4560.00
  • EUR 1052.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat)
4-PAJ769Ra01
  • EUR 259.00
  • EUR 2708.00
  • EUR 670.00
  • EUR 328.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Dog Von Hippel-Lindau disease tumor suppressor (pVHL) ELISA Kit
abx518740-96tests 96 tests
EUR 911

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), APC
4-PAJ769Ra01-APC
  • EUR 364.00
  • EUR 3545.00
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), Biotinylated
4-PAJ769Ra01-Biotin
  • EUR 325.00
  • EUR 2658.00
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  • EUR 400.00
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), Cy3
4-PAJ769Ra01-Cy3
  • EUR 444.00
  • EUR 4685.00
  • EUR 1265.00
  • EUR 581.00
  • EUR 261.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), FITC
4-PAJ769Ra01-FITC
  • EUR 311.00
  • EUR 2856.00
  • EUR 804.00
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  • EUR 202.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), HRP
4-PAJ769Ra01-HRP
  • EUR 332.00
  • EUR 3089.00
  • EUR 866.00
  • EUR 421.00
  • EUR 213.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), PE
4-PAJ769Ra01-PE
  • EUR 311.00
  • EUR 2856.00
  • EUR 804.00
  • EUR 393.00
  • EUR 202.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor Phospho-Ser68 (VHL pS68) Antibody
20-abx326675
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Mouse Von Hippel Lindau Tumor Suppressor ELISA Kit
ELA-E1894m 96 Tests
EUR 865

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), APC-Cy7
4-PAJ769Ra01-APC-Cy7
  • EUR 608.00
  • EUR 6970.00
  • EUR 1840.00
  • EUR 814.00
  • EUR 335.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

VHL Von Hippel-Lindau Protein Human Recombinant Protein
PROTP40337 Regular: 50ug
EUR 317

Polyclonal VHL / Von Hippel Lindau Antibody (aa34-83)
APR10721G 0.05ml
EUR 484

Von Hippel Lindau Antibody
20-abx008579
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Von Hippel Lindau antibody
70R-50541 100 ul
EUR 244

anti-Von Hippel Lindau
YF-PA15270 50 ul
EUR 363

anti-Von Hippel Lindau
YF-PA15271 50 ug
EUR 363

anti-Von Hippel Lindau
YF-PA15272 100 ug
EUR 403

anti-Von Hippel Lindau
YF-PA24955 50 ul
EUR 334

Von Hippel Lindau Blocking Peptide
20-abx063416
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Anti-Von Hippel Lindau (1G12)
YF-MA16056 100 ug
EUR 363

Monoclonal VHL / Von Hippel Lindau Antibody (clone 52A11), Clone: 52A11
APR10722G 0.05mg
EUR 484

Recombinant Human Von Hippel-Lindau Protein
7-06853 10µg Ask for price

Recombinant Human Von Hippel-Lindau Protein
7-06854 50µg Ask for price

Recombinant Human Von Hippel-Lindau Protein
7-06855 1mg Ask for price

Human Von Hippel- Lindau- like protein, VHLL ELISA KIT
ELI-16884h 96 Tests
EUR 824

Von Hippel-Lindau Binding Protein 1 Antibody
20-abx116632
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

von Hippel-Lindau-Like Protein (VHLL) Antibody
abx037324-100ug 100 ug
EUR 391

von Hippel-Lindau-Like Protein (VHLL) Antibody
20-abx301453
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

 

  • The gene encoding ‘deleted in breast most cancers 2’ (DBC2), additionally known as RHOBTB2 (Rho-related BTB domain-containing protein 2), is assessed as a tumor suppressor gene. DBC2 is a substrate-specific adaptor protein for a novel class of Cullin-3 (CUL3)-based E3 ubiquitin ligases; nonetheless, it’s unclear if the substrate adaptor operate of DBC2 is required for its tumor suppressor exercise. Moreover, the important thing substrates of DBC2-mediated ubiquitination have but to be recognized.

 

  • Within the current research, we established a genome-wide human cDNA library-based in vitro ubiquitination goal screening assay and recognized Musashi-2 (MSI2) as a novel ubiquitination goal protein of DBC2. MSI2 immediately interacted with DBC2, and this interplay promoted MSI2 polyubiquitination and proteasomal degradation in breast most cancers cells.

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment

  • Overexpression and knockdown experiments demonstrated that DBC2 suppressed MSI2-associated oncogenic features and induced apoptosis.

 

  • Immunohistochemistry evaluation of a breast most cancers tissue microarray revealed that DBC2 and MSI2 protein ranges are inversely correlated in each regular breast tissues and breast most cancers tissues. Taken collectively, these findings present proof that DBC2 suppresses tumorigenesis in breast most cancers by ubiquitinating MSI2.

Fhit, a tumor suppressor protein, induces autophagy via 14-3-3τ in non-small cell lung most cancers cells.

 

 

Von Hippel-Lindau Illness Tumor Suppressor (VHL) Antibody

 

 

Inactivation of the delicate histidine triad (Fhit) gene has been reported within the majority of human cancers, significantly in lung most cancers.

 

The function of Fhit as a tumor suppressor gene has been nicely documented, and restoration of Fhit expression suppresses tumorigenicity in tumor cell traces and in mouse fashions by inducing apoptosis and inhibiting proliferation of tumor cells.

 

Autophagy is a catabolic pathway, whereby cytoplasmic proteins and organelles are sequestered in vacuoles and delivered to lysosomes for degradation and recycling.

 

 

VHL Polyclonal Antibody
ABP56500-02ml 0.2ml
EUR 414

VHL Polyclonal Antibody
ABP60891-003ml 0.03ml
EUR 158

VHL Polyclonal Antibody
ABP60891-01ml 0.1ml
EUR 289

VHL Polyclonal Antibody
ABP60891-02ml 0.2ml
EUR 414

VHL Polyclonal Antibody
46866-100ul 100ul
EUR 252

VHL Polyclonal Antibody
46866-50ul 50ul
EUR 187

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Hu-48Tests 48 Tests
EUR 557

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Hu-96Tests 96 Tests
EUR 775

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Ra-48Tests 48 Tests
EUR 557

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Ra-96Tests 96 Tests
EUR 775

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
DLR-vHL-Hu-48T 48T
EUR 549

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
DLR-vHL-Hu-96T 96T
EUR 718

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
DLR-vHL-Ra-48T 48T
EUR 549

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
DLR-vHL-Ra-96T 96T
EUR 718

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Hu-48Tests 48 Tests
EUR 583

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Hu-96Tests 96 Tests
EUR 811

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Ra-48Tests 48 Tests
EUR 583

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Ra-96Tests 96 Tests
EUR 811

VHL (phospho Ser68) Polyclonal Antibody
ES7498-100ul 100ul
EUR 279

VHL (phospho Ser68) Polyclonal Antibody
ES7498-50ul 50ul
EUR 207

Polyclonal Goat Anti-VHL Antibody
AMM05157G 0.1 mg
EUR 484

Polyclonal VHL Antibody (C-term)
APR10723G 0.1ml
EUR 484

VHL (phospho Ser68) Polyclonal Antibody
ABP56499-003ml 0.03ml
EUR 158

VHL (phospho Ser68) Polyclonal Antibody
ABP56499-01ml 0.1ml
EUR 289

VHL (phospho Ser68) Polyclonal Antibody
ABP56499-02ml 0.2ml
EUR 414

VHL Antibody
1-CSB-PA991849
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul

VHL Antibody
1-CSB-PA060067
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug

VHL Antibody
1-CSB-PA071125
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul

VHL Antibody
CSB-PA025852KA01HU-
EUR 335

VHL Antibody
CSB-PA025852KA01HU-100ul 100ul
EUR 389

VHL Antibody
1-CSB-PA876839
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug

VHL Antibody
32075-100ul 100ul
EUR 252

VHL Antibody
AF6292 200ul
EUR 304

VHL Antibody
ABD6104 100 ug
EUR 438

VHL Antibody
DF6104 200ul
EUR 304

VHL Antibody
ABF6292 100 ug
EUR 438

VHL antibody
10R-1029 100 ul
EUR 316

VHL antibody
70R-34605 100 ug
EUR 327

VHL antibody
70R-9757 50 ug
EUR 467

VHL (Phospho-Ser68) Polyclonal Conjugated Antibody
C12654 100ul
EUR 397

Human VHL Antibody
32825-05111 150 ug
EUR 261

Anti-VHL antibody
STJ26089 100 µl
EUR 277

Anti-VHL antibody
STJ118733 100 µl
EUR 277

Anti-VHL Antibody
STJ502735 100 µg
EUR 476

Anti-VHL antibody
STJ113440 50 µl
EUR 277

Anti-VHL antibody
STJ113742 100 µl
EUR 277

VHL (pS68) Antibody
abx219320-100ug 100 ug
EUR 439

Anti-VHL antibody
STJ96241 200 µl
EUR 197

Anti-VHL antibody
STJ98809 200 µl
EUR 197

Anti-VHL antibody
STJ70964 100 µg
EUR 359

VHL Conjugated Antibody
C32075 100ul
EUR 397

anti- VHL antibody
FNab09402 100µg
EUR 548.75

anti- VHL antibody
FNab10175 100µg
EUR 505.25

Anti-VHL antibody
PAab09402 100 ug
EUR 386

Vhl/ Rat Vhl ELISA Kit
ELI-06080r 96 Tests
EUR 886

VHL/ Rat VHL ELISA Kit
ELA-E1894r 96 Tests
EUR 886

VHL siRNA
20-abx939411
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

VHL siRNA
20-abx939412
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

VHL siRNA
20-abx906024
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

VHL Peptide
45-170P 0.1 mg
EUR 338

Phospho-VHL (S68) Antibody
1-CSB-PA060066
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug

Anti-VHL Antibody (Biotin)
STJ502736 100 µg
EUR 586

Anti-VHL Antibody (FITC)
STJ502737 100 µg
EUR 586

VHL (Phospho-Ser68) Antibody
12654-100ul 100ul
EUR 252

VHL (Phospho-Ser68) Antibody
12654-50ul 50ul
EUR 187

Anti-VHL, Biotinylated antibody
STJ73173 100 µg
EUR 359

Phospho-VHL (Ser68) Antibody
AF8334 200ul
EUR 376

VHL (Phospho- Ser68) Antibody
ABF8334 100 ug
EUR 438

Polyclonal VHL / Von Hippel Lindau Antibody (aa34-83)
APR10721G 0.05ml
EUR 484

VHL cloning plasmid
CSB-CL025852HU-10ug 10ug
EUR 255

VHL Rabbit pAb
A0377-100ul 100 ul
EUR 308

VHL Rabbit pAb
A0377-200ul 200 ul
EUR 459

VHL Rabbit pAb
A0377-20ul 20 ul
EUR 183

VHL Rabbit pAb
A0377-50ul 50 ul
EUR 223

VHL Mouse mAb
A11872-100ul 100 ul Ask for price

VHL Mouse mAb
A11872-200ul 200 ul Ask for price

VHL Mouse mAb
A11872-20ul 20 ul Ask for price

VHL Mouse mAb
A11872-50ul 50 ul
EUR 265

VHL Rabbit pAb
A16287-100ul 100 ul
EUR 308

VHL Rabbit pAb
A16287-200ul 200 ul
EUR 459

VHL Rabbit pAb
A16287-20ul 20 ul
EUR 183

VHL Rabbit pAb
A16287-50ul 50 ul
EUR 223

VHL Rabbit pAb
A11240-100ul 100 ul
EUR 308

VHL Rabbit pAb
A11240-200ul 200 ul
EUR 459

VHL Rabbit pAb
A11240-20ul 20 ul
EUR 183

VHL Rabbit pAb
A11240-50ul 50 ul
EUR 223

Recombinant human VHL
P2120 100ug Ask for price

VHL Blocking Peptide
AF6292-BP 1mg
EUR 195

 

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment

Though autophagy is critical for cell survival underneath stress circumstances, latest research have proven that autophagy can even promote cell demise. On account of the truth that each autophagy induction and Fhit expression are generally related to nutrient hunger, we hypothesized that Fhit expression could also be associated to autophagy induction.

 

 

Within the current research, we assessed whether or not Fhit overexpression by gene switch induces autophagy in Fhit-deficient non-small cell lung most cancers (NSCLC) cells. The outcomes of our research point out that Fhit protein induces autophagy in NSCLC cells, and that this autophagy prevents apoptotic cell demise in vivo and in vitro in a 14-3-3τ protein-dependent method. To the perfect of our information, that is the primary report to explain Fhit-induced autophagy. Suppressing autophagy could be a promising therapeutic possibility to reinforce the efficacy of Fhit gene remedy in NSCLC.

Ronald

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