Best tumor suppressor protein

TOPORS, a tumor suppressor protein, contributes to the maintenance of higher-order chromatin architecture.

 

  • Within the nucleus, chromosomes are hierarchically folded into lively (A) and inactive (B) compartments composed of topologically associating domains (TADs). Genomic areas work together with nuclear lamina, termed lamina-associated domains (LADs). Nevertheless, the molecular mechanisms underlying these 3D chromatin architectures stay incompletely understood. Right here, we investigated the function of a possible tumor suppressor, TOP1 Binding Arginine/Serine Wealthy Protein (TOPORS), in genome group.

 

  • In mouse hepatocytes, chromatin interactions between A and B compartments enhance and compartmentalization power is lowered considerably upon Topors knockdown.

 

  • Correspondingly, power of TAD boundaries situated at A/B borders is weakened. Within the absence of TOPORS, chromatin-lamina interactions lower and the protection of LADs reduces from 53.31% to 46.52%. Apparently, these adjustments in 3D genome are related to PML nuclear our bodies and PML-associated domains (PADs).

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment

  • Furthermore, chromatin accessibility is altered predominantly at intergenic regions upon Topors knockdown, together with a subset of enhancers.

 

  • These alterations of chromatin are concordant with transcriptome adjustments, that are related to carcinogenesis. Collectively, our findings demonstrate that TOPORS features as a regulator in chromatin construction, offering novel perception into the architectural roles of tumor suppressors in higher-order genome organization.

 

 

 

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RDR-vHL-Hu-48Tests 48 Tests
EUR 699.6

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RDR-vHL-Hu-96Tests 96 Tests
EUR 973.2

Human Von Hippel-Lindau disease tumor suppressor (VHL)

1-CSB-EP025852HU
  • EUR 606.00
  • EUR 318.00
  • EUR 2192.40
  • EUR 919.20
  • EUR 1461.60
  • EUR 402.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

DLR-vHL-Ra-48T 48T
EUR 658.8

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

DLR-vHL-Ra-96T 96T
EUR 861.6

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RD-vHL-Ra-48Tests 48 Tests
EUR 668.4

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RD-vHL-Ra-96Tests 96 Tests
EUR 930

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RDR-vHL-Ra-48Tests 48 Tests
EUR 699.6

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RDR-vHL-Ra-96Tests 96 Tests
EUR 973.2

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody

20-abx137392
  • EUR 844.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 20 ug
  • 5 ug

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody

20-abx000699
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody

abx125410-50ul 50 ul
EUR 427.2

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody

abx117007-100ug 100 ug
EUR 560.4

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody

20-abx126781
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody

abx012353-100ug 100 ug
EUR 526.8

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody

abx032864-400ul 400 ul
EUR 627.6

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody

abx032864-80l 80 µl
EUR 343.2

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody

abx032865-400ul 400 ul
EUR 627.6

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody

abx032865-80l 80 µl
EUR 343.2

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody

abx219331-100ug 100 ug
EUR 526.8

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Protein

20-abx260439
  • EUR 276.00
  • EUR 2798.40
  • EUR 393.60
  • 10 ug
  • 1 mg
  • 50 ug

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody

abx431703-200ul 200 ul
EUR 460.8

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody

abx239402-100ug 100 ug
EUR 610.8

Human VHL(Von Hippel-Lindau disease tumor suppressor) ELISA Kit

EH1986 96T
EUR 681.12

Human VHL/ Von Hippel-Lindau disease tumor suppressor ELISA Kit

E2661Hu 1 Kit
EUR 685.2

Human Von Hippel- Lindau disease tumor suppressor, VHL ELISA KIT

ELI-06082h 96 Tests
EUR 988.8

Mouse Von Hippel- Lindau disease tumor suppressor, Vhl ELISA KIT

ELI-06081m 96 Tests
EUR 1038

Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody (Biotin)

abx431704-200ul 200 ul
EUR 460.8

Von Hippel Lindau Tumor Suppressor (vHL) Antibody

20-abx131162
  • EUR 543.60
  • EUR 159.60
  • EUR 1562.40
  • EUR 744.00
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Von Hippel Lindau Tumor Suppressor (VHL) Antibody

20-abx210322
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Von Hippel Lindau Tumor Suppressor (VHL) Antibody

20-abx323201
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Von Hippel Lindau Tumor Suppressor (VHL) Antibody

20-abx326550
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Von Hippel Lindau Tumor Suppressor (VHL) Antibody

20-abx211119
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Von Hippel Lindau Tumor Suppressor (vHL) Antibody

20-abx175113
  • EUR 1095.60
  • EUR 560.40
  • 1 mg
  • 200 ug

Recombinant Von Hippel Lindau Tumor Suppressor (vHL)

4-RPJ769Ra01
  • EUR 614.59
  • EUR 288.00
  • EUR 1974.72
  • EUR 738.24
  • EUR 1356.48
  • EUR 487.20
  • EUR 4756.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg

Human Von Hippel-Lindau Tumor Suppressor (VHL) ELISA Kit

abx251310-96tests 96 tests
EUR 895.2

Human Von Hippel-Lindau Tumor Suppressor (VHL) ELISA Kit

abx576631-96tests 96 tests
EUR 801.6

ELISA kit for Rat vHL (Von Hippel Lindau Tumor Suppressor)

ELK6800 1 plate of 96 wells
EUR 518.4

ELISA kit for Human Von Hippel-Lindau disease tumor suppressor

EK4060 96 tests
EUR 663.6

Rat Von Hippel-Lindau Tumor Suppressor (VHL) ELISA Kit

20-abx156227
  • EUR 8684.40
  • EUR 4626.00
  • EUR 1074.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Von Hippel-Lindau Tumor Suppressor (VHL) ELISA Kit

abx518742-96tests 96 tests
EUR 801.6

Rat Von Hippel-Lindau Tumor Suppressor (VHL) ELISA Kit

abx572904-96tests 96 tests
EUR 801.6

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

SEJ769Ra-10x96wellstestplate 10x96-wells test plate
EUR 6149.04

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

SEJ769Ra-1x48wellstestplate 1x48-wells test plate
EUR 611.57

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

SEJ769Ra-1x96wellstestplate 1x96-wells test plate
EUR 822.24

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

SEJ769Ra-5x96wellstestplate 5x96-wells test plate
EUR 3340.08

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

4-SEJ769Ra
  • EUR 6210.00
  • EUR 3280.80
  • EUR 823.20
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells

Rat Von Hippel Lindau Tumor Suppressor (vHL) Protein

20-abx650771
  • EUR 861.60
  • EUR 343.20
  • EUR 2665.20
  • EUR 1028.40
  • EUR 610.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rat Von Hippel Lindau Tumor Suppressor (vHL) CLIA Kit

20-abx495777
  • EUR 10282.80
  • EUR 5472.00
  • EUR 1262.40
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat)

4-PAJ769Ra01
  • EUR 310.80
  • EUR 3249.60
  • EUR 804.00
  • EUR 393.60
  • EUR 262.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Dog Von Hippel-Lindau disease tumor suppressor (pVHL) ELISA Kit

abx518740-96tests 96 tests
EUR 1093.2

Von Hippel Lindau Tumor Suppressor Phospho-Ser68 (VHL pS68) Antibody

20-abx326675
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), APC

4-PAJ769Ra01-APC
  • EUR 436.80
  • EUR 4254.00
  • EUR 1176.00
  • EUR 560.40
  • EUR 272.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), Biotinylated

4-PAJ769Ra01-Biotin
  • EUR 390.00
  • EUR 3189.60
  • EUR 932.40
  • EUR 480.00
  • EUR 270.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), Cy3

4-PAJ769Ra01-Cy3
  • EUR 532.80
  • EUR 5622.00
  • EUR 1518.00
  • EUR 697.20
  • EUR 313.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), FITC

4-PAJ769Ra01-FITC
  • EUR 373.20
  • EUR 3427.20
  • EUR 964.80
  • EUR 471.60
  • EUR 242.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), HRP

4-PAJ769Ra01-HRP
  • EUR 398.40
  • EUR 3706.80
  • EUR 1039.20
  • EUR 505.20
  • EUR 255.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), PE

4-PAJ769Ra01-PE
  • EUR 373.20
  • EUR 3427.20
  • EUR 964.80
  • EUR 471.60
  • EUR 242.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

Mouse Von Hippel Lindau Tumor Suppressor ELISA Kit

ELA-E1894m 96 Tests
EUR 1038

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), APC-Cy7

4-PAJ769Ra01-APC-Cy7
  • EUR 729.60
  • EUR 8364.00
  • EUR 2208.00
  • EUR 976.80
  • EUR 402.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul

VHL Von Hippel-Lindau Protein Human Recombinant Protein

PROTP40337 Regular: 50ug
EUR 380.4

Polyclonal VHL / Von Hippel Lindau Antibody (aa34-83)

APR10721G 0.05ml
EUR 580.8

Von Hippel Lindau antibody

70R-50541 100 ul
EUR 292.8

Von Hippel Lindau Antibody

20-abx008579
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

anti-Von Hippel Lindau

YF-PA24955 50 ul
EUR 400.8

anti-Von Hippel Lindau

YF-PA15270 50 ul
EUR 435.6

anti-Von Hippel Lindau

YF-PA15271 50 ug
EUR 435.6

anti-Von Hippel Lindau

YF-PA15272 100 ug
EUR 483.6

Von Hippel Lindau Blocking Peptide

20-abx063416
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

Anti-Von Hippel Lindau (1G12)

YF-MA16056 100 ug
EUR 435.6

Monoclonal VHL / Von Hippel Lindau Antibody (clone 52A11), Clone: 52A11

APR10722G 0.05mg
EUR 580.8

Recombinant Human Von Hippel-Lindau Protein

7-06853 10µg Ask for price

Recombinant Human Von Hippel-Lindau Protein

7-06854 50µg Ask for price

Recombinant Human Von Hippel-Lindau Protein

7-06855 1mg Ask for price

Human Von Hippel- Lindau- like protein, VHLL ELISA KIT

ELI-16884h 96 Tests
EUR 988.8

Von Hippel-Lindau Binding Protein 1 Antibody

20-abx116632
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

von Hippel-Lindau-Like Protein (VHLL) Antibody

abx037324-100ug 100 ug
EUR 469.2

von Hippel-Lindau-Like Protein (VHLL) Antibody

20-abx301453
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

 

  • The gene encoding ‘deleted in breast most cancers 2’ (DBC2), additionally known as RHOBTB2 (Rho-related BTB domain-containing protein 2), is assessed as a tumor suppressor gene. DBC2 is a substrate-specific adaptor protein for a novel class of Cullin-3 (CUL3)-based E3 ubiquitin ligases; nonetheless, it’s unclear if the substrate adaptor operate of DBC2 is required for its tumor suppressor exercise. Moreover, the important thing substrates of DBC2-mediated ubiquitination have but to be recognized.

 

  • Within the current research, we established a genome-wide human cDNA library-based in vitro ubiquitination goal screening assay and recognized Musashi-2 (MSI2) as a novel ubiquitination goal protein of DBC2. MSI2 immediately interacted with DBC2, and this interplay promoted MSI2 polyubiquitination and proteasomal degradation in breast most cancers cells.

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment

  • Overexpression and knockdown experiments demonstrated that DBC2 suppressed MSI2-associated oncogenic features and induced apoptosis.

 

  • Immunohistochemistry evaluation of a breast most cancers tissue microarray revealed that DBC2 and MSI2 protein ranges are inversely correlated in each regular breast tissues and breast most cancers tissues. Taken collectively, these findings present proof that DBC2 suppresses tumorigenesis in breast most cancers by ubiquitinating MSI2.

Fhit, a tumor suppressor protein, induces autophagy via 14-3-3τ in non-small cell lung most cancers cells.

 

 

Von Hippel-Lindau Illness Tumor Suppressor (VHL) Antibody

 

 

Inactivation of the delicate histidine triad (Fhit) gene has been reported within the majority of human cancers, significantly in lung most cancers.

 

The function of Fhit as a tumor suppressor gene has been nicely documented, and restoration of Fhit expression suppresses tumorigenicity in tumor cell traces and in mouse fashions by inducing apoptosis and inhibiting proliferation of tumor cells.

 

Autophagy is a catabolic pathway, whereby cytoplasmic proteins and organelles are sequestered in vacuoles and delivered to lysosomes for degradation and recycling.

 

 

VHL Polyclonal Antibody

ABP56500-003ml 0.03ml
EUR 189.6

VHL Polyclonal Antibody

ABP56500-01ml 0.1ml
EUR 346.8

VHL Polyclonal Antibody

ABP56500-02ml 0.2ml
EUR 496.8

VHL Polyclonal Antibody

ABP60891-003ml 0.03ml
EUR 189.6

VHL Polyclonal Antibody

ABP60891-01ml 0.1ml
EUR 346.8

VHL Polyclonal Antibody

ABP60891-02ml 0.2ml
EUR 496.8

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

DLR-vHL-Hu-48T 48T
EUR 658.8

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

DLR-vHL-Hu-96T 96T
EUR 861.6

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

DLR-vHL-Ra-48T 48T
EUR 658.8

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

DLR-vHL-Ra-96T 96T
EUR 861.6

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RD-vHL-Hu-48Tests 48 Tests
EUR 668.4

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RD-vHL-Hu-96Tests 96 Tests
EUR 930

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RD-vHL-Ra-48Tests 48 Tests
EUR 668.4

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RD-vHL-Ra-96Tests 96 Tests
EUR 930

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RDR-vHL-Hu-48Tests 48 Tests
EUR 699.6

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RDR-vHL-Hu-96Tests 96 Tests
EUR 973.2

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RDR-vHL-Ra-48Tests 48 Tests
EUR 699.6

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RDR-vHL-Ra-96Tests 96 Tests
EUR 973.2

VHL Antibody

1-CSB-PA071125
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul

VHL Antibody

1-CSB-PA060067
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug

VHL Antibody

1-CSB-PA991849
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul

VHL Antibody

DF6104 200ul
EUR 420

VHL Antibody

AF6292 200ul
EUR 420

VHL Antibody

1-CSB-PA876839
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug

VHL Antibody

CSB-PA025852KA01HU-
EUR 402

VHL Antibody

CSB-PA025852KA01HU-100ul 100ul
EUR 466.8

VHL antibody

70R-34605 100 ug
EUR 392.4

VHL antibody

70R-9757 50 ug
EUR 560.4

VHL Antibody

32075-100ul 100ul
EUR 302.4

VHL antibody

10R-1029 100 ul
EUR 379.2

VHL Antibody

ABF6292 100 ug
EUR 525.6

VHL Antibody

ABD6104 100 ug
EUR 525.6

VHL Antibody

F49681-0.05ML 0.05 ml
EUR 165

VHL Antibody

F49681-0.2ML 0.2 ml
EUR 379

VHL Antibody

F49682-0.08ML 0.08 ml
EUR 165

VHL Antibody

F49682-0.4ML 0.4 ml
EUR 389

VHL Antibody

R35773-100UG 100 ug
EUR 399

VHL (phospho Ser68) Polyclonal Antibody

ES7498-100ul 100ul
EUR 334.8

VHL (phospho Ser68) Polyclonal Antibody

ES7498-50ul 50ul
EUR 248.4

VHL (phospho Ser68) Polyclonal Antibody

ABP56499-003ml 0.03ml
EUR 189.6

VHL (phospho Ser68) Polyclonal Antibody

ABP56499-01ml 0.1ml
EUR 346.8

VHL (phospho Ser68) Polyclonal Antibody

ABP56499-02ml 0.2ml
EUR 496.8

Polyclonal VHL Antibody (C-term)

APR10723G 0.1ml
EUR 580.8

Polyclonal Goat Anti-VHL Antibody

AMM05157G 0.1 mg
EUR 580.8

VHL/ Rat VHL ELISA Kit

ELA-E1894r 96 Tests
EUR 1063.2

Vhl/ Rat Vhl ELISA Kit

ELI-06080r 96 Tests
EUR 1063.2

VHL Conjugated Antibody

C32075 100ul
EUR 476.4

Human VHL Antibody

32825-05111 150 ug
EUR 313.2

VHL (pS68) Antibody

abx219320-100ug 100 ug
EUR 526.8

anti- VHL antibody

FNab09402 100µg
EUR 658.5

anti- VHL antibody

FNab10175 100µg
EUR 606.3

Anti-VHL antibody

PAab09402 100 ug
EUR 463.2

Anti-VHL antibody

STJ113440 50 µl
EUR 332.4

Anti-VHL antibody

STJ113742 100 µl
EUR 332.4

Anti-VHL antibody

STJ26089 100 µl
EUR 332.4

Anti-VHL Antibody

STJ502735 100 µg
EUR 571.2

Anti-VHL antibody

STJ70964 100 µg
EUR 430.8

Anti-VHL antibody

STJ118733 100 µl
EUR 332.4

Anti-VHL antibody

STJ96241 200 µl
EUR 236.4

Anti-VHL antibody

STJ98809 200 µl
EUR 236.4

VHL (Phospho-Ser68) Polyclonal Conjugated Antibody

C12654 100ul
EUR 476.4

VHL siRNA

20-abx939411
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

VHL siRNA

20-abx939412
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

VHL Peptide

45-170P 0.1 mg
EUR 405.6

VHL siRNA

20-abx906024
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

Phospho-VHL (S68) Antibody

1-CSB-PA060066
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug

Phospho-VHL (Ser68) Antibody

AF8334 200ul
EUR 540

VHL (Phospho-Ser68) Antibody

12654-100ul 100ul
EUR 302.4

VHL (Phospho-Ser68) Antibody

12654-50ul 50ul
EUR 224.4

VHL (Phospho- Ser68) Antibody

ABF8334 100 ug
EUR 525.6

Anti-VHL Antibody (Biotin)

STJ502736 100 µg
EUR 703.2

Anti-VHL Antibody (FITC)

STJ502737 100 µg
EUR 703.2

Anti-VHL, Biotinylated antibody

STJ73173 100 µg
EUR 430.8

Polyclonal VHL / Von Hippel Lindau Antibody (aa34-83)

APR10721G 0.05ml
EUR 580.8

VHL Blocking Peptide

DF6104-BP 1mg
EUR 234

VHL Blocking Peptide

AF6292-BP 1mg
EUR 234

VHL cloning plasmid

CSB-CL025852HU-10ug 10ug
EUR 306

VHL Rabbit pAb

A11240-100ul 100 ul
EUR 369.6

VHL Rabbit pAb

A11240-200ul 200 ul
EUR 550.8

VHL Rabbit pAb

A11240-20ul 20 ul
EUR 219.6

VHL Rabbit pAb

A11240-50ul 50 ul
EUR 267.6

VHL Mouse mAb

A11872-100ul 100 ul Ask for price

VHL Mouse mAb

A11872-200ul 200 ul Ask for price

VHL Mouse mAb

A11872-20ul 20 ul Ask for price

VHL Mouse mAb

A11872-50ul 50 ul
EUR 318

VHL Blocking Peptide

33R-2312 100 ug
EUR 216

VHL Rabbit pAb

A16287-100ul 100 ul
EUR 369.6

VHL Rabbit pAb

A16287-200ul 200 ul
EUR 550.8

 

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment

Though autophagy is critical for cell survival underneath stress circumstances, latest research have proven that autophagy can even promote cell demise. On account of the truth that each autophagy induction and Fhit expression are generally related to nutrient hunger, we hypothesized that Fhit expression could also be associated to autophagy induction.

 

 

Within the current research, we assessed whether or not Fhit overexpression by gene switch induces autophagy in Fhit-deficient non-small cell lung most cancers (NSCLC) cells. The outcomes of our research point out that Fhit protein induces autophagy in NSCLC cells, and that this autophagy prevents apoptotic cell demise in vivo and in vitro in a 14-3-3τ protein-dependent method. To the perfect of our information, that is the primary report to explain Fhit-induced autophagy. Suppressing autophagy could be a promising therapeutic possibility to reinforce the efficacy of Fhit gene remedy in NSCLC.

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