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Best tumor suppressor protein
TOPORS, a tumor suppressor protein, contributes to the maintenance of higher-order chromatin architecture.
- Within the nucleus, chromosomes are hierarchically folded into lively (A) and inactive (B) compartments composed of topologically associating domains (TADs). Genomic areas work together with nuclear lamina, termed lamina-associated domains (LADs). Nevertheless, the molecular mechanisms underlying these 3D chromatin architectures stay incompletely understood. Right here, we investigated the function of a possible tumor suppressor, TOP1 Binding Arginine/Serine Wealthy Protein (TOPORS), in genome group.
- In mouse hepatocytes, chromatin interactions between A and B compartments enhance and compartmentalization power is lowered considerably upon Topors knockdown.
- Correspondingly, power of TAD boundaries situated at A/B borders is weakened. Within the absence of TOPORS, chromatin-lamina interactions lower and the protection of LADs reduces from 53.31% to 46.52%. Apparently, these adjustments in 3D genome are related to PML nuclear our bodies and PML-associated domains (PADs).
Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment
- Furthermore, chromatin accessibility is altered predominantly at intergenic regions upon Topors knockdown, together with a subset of enhancers.
- These alterations of chromatin are concordant with transcriptome adjustments, that are related to carcinogenesis. Collectively, our findings demonstrate that TOPORS features as a regulator in chromatin construction, offering novel perception into the architectural roles of tumor suppressors in higher-order genome organization.

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
RDR-vHL-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 699.6 |
Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
RDR-vHL-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 973.2 |
Human Von Hippel-Lindau disease tumor suppressor (VHL) |
1-CSB-EP025852HU |
Cusabio |
-
EUR 606.00
-
EUR 318.00
-
EUR 2192.40
-
EUR 919.20
-
EUR 1461.60
-
EUR 402.00
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
DLR-vHL-Ra-48T |
DL Develop |
48T |
EUR 658.8 |
Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
DLR-vHL-Ra-96T |
DL Develop |
96T |
EUR 861.6 |
Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
RD-vHL-Ra-48Tests |
Reddot Biotech |
48 Tests |
EUR 668.4 |
Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
RD-vHL-Ra-96Tests |
Reddot Biotech |
96 Tests |
EUR 930 |
Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
RDR-vHL-Ra-48Tests |
Reddot Biotech |
48 Tests |
EUR 699.6 |
Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
RDR-vHL-Ra-96Tests |
Reddot Biotech |
96 Tests |
EUR 973.2 |
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
20-abx137392 |
Abbexa |
-
EUR 844.80
-
EUR 393.60
-
EUR 276.00
|
|
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
20-abx000699 |
Abbexa |
-
EUR 493.20
-
EUR 710.40
-
EUR 218.40
-
EUR 376.80
|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
abx125410-50ul |
Abbexa |
50 ul |
EUR 427.2 |
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
abx117007-100ug |
Abbexa |
100 ug |
EUR 560.4 |
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
20-abx126781 |
Abbexa |
-
EUR 493.20
-
EUR 710.40
-
EUR 218.40
-
EUR 376.80
|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
abx012353-100ug |
Abbexa |
100 ug |
EUR 526.8 |
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
abx032864-400ul |
Abbexa |
400 ul |
EUR 627.6 |
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
abx032864-80l |
Abbexa |
80 µl |
EUR 343.2 |
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
abx032865-400ul |
Abbexa |
400 ul |
EUR 627.6 |
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
abx032865-80l |
Abbexa |
80 µl |
EUR 343.2 |
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
abx219331-100ug |
Abbexa |
100 ug |
EUR 526.8 |
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Protein |
20-abx260439 |
Abbexa |
-
EUR 276.00
-
EUR 2798.40
-
EUR 393.60
|
|
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
abx431703-200ul |
Abbexa |
200 ul |
EUR 460.8 |
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
abx239402-100ug |
Abbexa |
100 ug |
EUR 610.8 |
Human VHL(Von Hippel-Lindau disease tumor suppressor) ELISA Kit |
EH1986 |
FN Test |
96T |
EUR 681.12 |
Human VHL/ Von Hippel-Lindau disease tumor suppressor ELISA Kit |
E2661Hu |
Sunlong |
1 Kit |
EUR 685.2 |
Human Von Hippel- Lindau disease tumor suppressor, VHL ELISA KIT |
ELI-06082h |
Lifescience Market |
96 Tests |
EUR 988.8 |
Mouse Von Hippel- Lindau disease tumor suppressor, Vhl ELISA KIT |
ELI-06081m |
Lifescience Market |
96 Tests |
EUR 1038 |
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody (Biotin) |
abx431704-200ul |
Abbexa |
200 ul |
EUR 460.8 |
Von Hippel Lindau Tumor Suppressor (vHL) Antibody |
20-abx131162 |
Abbexa |
-
EUR 543.60
-
EUR 159.60
-
EUR 1562.40
-
EUR 744.00
-
EUR 410.40
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
Von Hippel Lindau Tumor Suppressor (VHL) Antibody |
20-abx210322 |
Abbexa |
|
|
Von Hippel Lindau Tumor Suppressor (VHL) Antibody |
20-abx323201 |
Abbexa |
|
|
Von Hippel Lindau Tumor Suppressor (VHL) Antibody |
20-abx326550 |
Abbexa |
|
|
Von Hippel Lindau Tumor Suppressor (VHL) Antibody |
20-abx211119 |
Abbexa |
|
|
Von Hippel Lindau Tumor Suppressor (vHL) Antibody |
20-abx175113 |
Abbexa |
|
|
Recombinant Von Hippel Lindau Tumor Suppressor (vHL) |
4-RPJ769Ra01 |
Cloud-Clone |
-
EUR 614.59
-
EUR 288.00
-
EUR 1974.72
-
EUR 738.24
-
EUR 1356.48
-
EUR 487.20
-
EUR 4756.80
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
Human Von Hippel-Lindau Tumor Suppressor (VHL) ELISA Kit |
abx251310-96tests |
Abbexa |
96 tests |
EUR 895.2 |
Human Von Hippel-Lindau Tumor Suppressor (VHL) ELISA Kit |
abx576631-96tests |
Abbexa |
96 tests |
EUR 801.6 |
ELISA kit for Rat vHL (Von Hippel Lindau Tumor Suppressor) |
ELK6800 |
ELK Biotech |
1 plate of 96 wells |
EUR 518.4 |
ELISA kit for Human Von Hippel-Lindau disease tumor suppressor |
EK4060 |
SAB |
96 tests |
EUR 663.6 |
Rat Von Hippel-Lindau Tumor Suppressor (VHL) ELISA Kit |
20-abx156227 |
Abbexa |
-
EUR 8684.40
-
EUR 4626.00
-
EUR 1074.00
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
Mouse Von Hippel-Lindau Tumor Suppressor (VHL) ELISA Kit |
abx518742-96tests |
Abbexa |
96 tests |
EUR 801.6 |
Rat Von Hippel-Lindau Tumor Suppressor (VHL) ELISA Kit |
abx572904-96tests |
Abbexa |
96 tests |
EUR 801.6 |
Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
SEJ769Ra-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 6149.04 |
Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
SEJ769Ra-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 611.57 |
Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
SEJ769Ra-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 822.24 |
Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
SEJ769Ra-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 3340.08 |
Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
4-SEJ769Ra |
Cloud-Clone |
-
EUR 6210.00
-
EUR 3280.80
-
EUR 823.20
|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
|
Rat Von Hippel Lindau Tumor Suppressor (vHL) Protein |
20-abx650771 |
Abbexa |
-
EUR 861.60
-
EUR 343.20
-
EUR 2665.20
-
EUR 1028.40
-
EUR 610.80
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
Rat Von Hippel Lindau Tumor Suppressor (vHL) CLIA Kit |
20-abx495777 |
Abbexa |
-
EUR 10282.80
-
EUR 5472.00
-
EUR 1262.40
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat) |
4-PAJ769Ra01 |
Cloud-Clone |
-
EUR 310.80
-
EUR 3249.60
-
EUR 804.00
-
EUR 393.60
-
EUR 262.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
Dog Von Hippel-Lindau disease tumor suppressor (pVHL) ELISA Kit |
abx518740-96tests |
Abbexa |
96 tests |
EUR 1093.2 |
Von Hippel Lindau Tumor Suppressor Phospho-Ser68 (VHL pS68) Antibody |
20-abx326675 |
Abbexa |
|
|
Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), APC |
4-PAJ769Ra01-APC |
Cloud-Clone |
-
EUR 436.80
-
EUR 4254.00
-
EUR 1176.00
-
EUR 560.40
-
EUR 272.40
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), Biotinylated |
4-PAJ769Ra01-Biotin |
Cloud-Clone |
-
EUR 390.00
-
EUR 3189.60
-
EUR 932.40
-
EUR 480.00
-
EUR 270.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), Cy3 |
4-PAJ769Ra01-Cy3 |
Cloud-Clone |
-
EUR 532.80
-
EUR 5622.00
-
EUR 1518.00
-
EUR 697.20
-
EUR 313.20
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), FITC |
4-PAJ769Ra01-FITC |
Cloud-Clone |
-
EUR 373.20
-
EUR 3427.20
-
EUR 964.80
-
EUR 471.60
-
EUR 242.40
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), HRP |
4-PAJ769Ra01-HRP |
Cloud-Clone |
-
EUR 398.40
-
EUR 3706.80
-
EUR 1039.20
-
EUR 505.20
-
EUR 255.60
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), PE |
4-PAJ769Ra01-PE |
Cloud-Clone |
-
EUR 373.20
-
EUR 3427.20
-
EUR 964.80
-
EUR 471.60
-
EUR 242.40
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
Mouse Von Hippel Lindau Tumor Suppressor ELISA Kit |
ELA-E1894m |
Lifescience Market |
96 Tests |
EUR 1038 |
Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), APC-Cy7 |
4-PAJ769Ra01-APC-Cy7 |
Cloud-Clone |
-
EUR 729.60
-
EUR 8364.00
-
EUR 2208.00
-
EUR 976.80
-
EUR 402.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
VHL Von Hippel-Lindau Protein Human Recombinant Protein |
PROTP40337 |
BosterBio |
Regular: 50ug |
EUR 380.4 |
Polyclonal VHL / Von Hippel Lindau Antibody (aa34-83) |
APR10721G |
Leading Biology |
0.05ml |
EUR 580.8 |
Von Hippel Lindau antibody |
70R-50541 |
Fitzgerald |
100 ul |
EUR 292.8 |
Von Hippel Lindau Antibody |
20-abx008579 |
Abbexa |
-
EUR 360.00
-
EUR 526.80
-
EUR 226.80
|
|
anti-Von Hippel Lindau |
YF-PA24955 |
Abfrontier |
50 ul |
EUR 400.8 |
anti-Von Hippel Lindau |
YF-PA15270 |
Abfrontier |
50 ul |
EUR 435.6 |
anti-Von Hippel Lindau |
YF-PA15271 |
Abfrontier |
50 ug |
EUR 435.6 |
anti-Von Hippel Lindau |
YF-PA15272 |
Abfrontier |
100 ug |
EUR 483.6 |
Von Hippel Lindau Blocking Peptide |
20-abx063416 |
Abbexa |
|
|
Anti-Von Hippel Lindau (1G12) |
YF-MA16056 |
Abfrontier |
100 ug |
EUR 435.6 |
Monoclonal VHL / Von Hippel Lindau Antibody (clone 52A11), Clone: 52A11 |
APR10722G |
Leading Biology |
0.05mg |
EUR 580.8 |
Recombinant Human Von Hippel-Lindau Protein |
7-06853 |
CHI Scientific |
10µg |
Ask for price |
Recombinant Human Von Hippel-Lindau Protein |
7-06854 |
CHI Scientific |
50µg |
Ask for price |
Recombinant Human Von Hippel-Lindau Protein |
7-06855 |
CHI Scientific |
1mg |
Ask for price |
Human Von Hippel- Lindau- like protein, VHLL ELISA KIT |
ELI-16884h |
Lifescience Market |
96 Tests |
EUR 988.8 |
Von Hippel-Lindau Binding Protein 1 Antibody |
20-abx116632 |
Abbexa |
|
|
von Hippel-Lindau-Like Protein (VHLL) Antibody |
abx037324-100ug |
Abbexa |
100 ug |
EUR 469.2 |
von Hippel-Lindau-Like Protein (VHLL) Antibody |
20-abx301453 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
- The gene encoding ‘deleted in breast most cancers 2’ (DBC2), additionally known as RHOBTB2 (Rho-related BTB domain-containing protein 2), is assessed as a tumor suppressor gene. DBC2 is a substrate-specific adaptor protein for a novel class of Cullin-3 (CUL3)-based E3 ubiquitin ligases; nonetheless, it’s unclear if the substrate adaptor operate of DBC2 is required for its tumor suppressor exercise. Moreover, the important thing substrates of DBC2-mediated ubiquitination have but to be recognized.
- Within the current research, we established a genome-wide human cDNA library-based in vitro ubiquitination goal screening assay and recognized Musashi-2 (MSI2) as a novel ubiquitination goal protein of DBC2. MSI2 immediately interacted with DBC2, and this interplay promoted MSI2 polyubiquitination and proteasomal degradation in breast most cancers cells.
Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment
- Overexpression and knockdown experiments demonstrated that DBC2 suppressed MSI2-associated oncogenic features and induced apoptosis.
- Immunohistochemistry evaluation of a breast most cancers tissue microarray revealed that DBC2 and MSI2 protein ranges are inversely correlated in each regular breast tissues and breast most cancers tissues. Taken collectively, these findings present proof that DBC2 suppresses tumorigenesis in breast most cancers by ubiquitinating MSI2.
Fhit, a tumor suppressor protein, induces autophagy via 14-3-3τ in non-small cell lung most cancers cells.
Von Hippel-Lindau Illness Tumor Suppressor (VHL) Antibody
Inactivation of the delicate histidine triad (Fhit) gene has been reported within the majority of human cancers, significantly in lung most cancers.
The function of Fhit as a tumor suppressor gene has been nicely documented, and restoration of Fhit expression suppresses tumorigenicity in tumor cell traces and in mouse fashions by inducing apoptosis and inhibiting proliferation of tumor cells.
Autophagy is a catabolic pathway, whereby cytoplasmic proteins and organelles are sequestered in vacuoles and delivered to lysosomes for degradation and recycling.
VHL Polyclonal Antibody |
ABP56500-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
VHL Polyclonal Antibody |
ABP56500-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
VHL Polyclonal Antibody |
ABP56500-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
VHL Polyclonal Antibody |
ABP60891-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
VHL Polyclonal Antibody |
ABP60891-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
VHL Polyclonal Antibody |
ABP60891-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
DLR-vHL-Hu-48T |
DL Develop |
48T |
EUR 658.8 |
Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
DLR-vHL-Hu-96T |
DL Develop |
96T |
EUR 861.6 |
Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
DLR-vHL-Ra-48T |
DL Develop |
48T |
EUR 658.8 |
Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
DLR-vHL-Ra-96T |
DL Develop |
96T |
EUR 861.6 |
Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
RD-vHL-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 668.4 |
Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
RD-vHL-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 930 |
Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
RD-vHL-Ra-48Tests |
Reddot Biotech |
48 Tests |
EUR 668.4 |
Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
RD-vHL-Ra-96Tests |
Reddot Biotech |
96 Tests |
EUR 930 |
Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
RDR-vHL-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 699.6 |
Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
RDR-vHL-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 973.2 |
Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
RDR-vHL-Ra-48Tests |
Reddot Biotech |
48 Tests |
EUR 699.6 |
Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit |
RDR-vHL-Ra-96Tests |
Reddot Biotech |
96 Tests |
EUR 973.2 |
VHL Antibody |
1-CSB-PA071125 |
Cusabio |
|
|
VHL Antibody |
1-CSB-PA060067 |
Cusabio |
|
|
VHL Antibody |
1-CSB-PA991849 |
Cusabio |
|
|
VHL Antibody |
1-CSB-PA876839 |
Cusabio |
|
|
VHL Antibody |
CSB-PA025852KA01HU- |
Cusabio |
|
EUR 402 |
VHL Antibody |
CSB-PA025852KA01HU-100ul |
Cusabio |
100ul |
EUR 466.8 |
VHL antibody |
70R-34605 |
Fitzgerald |
100 ug |
EUR 392.4 |
VHL Antibody |
32075-100ul |
SAB |
100ul |
EUR 302.4 |
VHL (phospho Ser68) Polyclonal Antibody |
ES7498-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
VHL (phospho Ser68) Polyclonal Antibody |
ES7498-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
VHL (phospho Ser68) Polyclonal Antibody |
ABP56499-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
VHL (phospho Ser68) Polyclonal Antibody |
ABP56499-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
VHL (phospho Ser68) Polyclonal Antibody |
ABP56499-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
Polyclonal Goat Anti-VHL Antibody |
AMM05157G |
Leading Biology |
0.1 mg |
EUR 580.8 |
VHL Conjugated Antibody |
C32075 |
SAB |
100ul |
EUR 476.4 |
Human VHL Antibody |
32825-05111 |
AssayPro |
150 ug |
EUR 313.2 |
VHL (pS68) Antibody |
abx219320-100ug |
Abbexa |
100 ug |
EUR 526.8 |
anti- VHL antibody |
FNab09402 |
FN Test |
100µg |
EUR 658.5 |
anti- VHL antibody |
FNab10175 |
FN Test |
100µg |
EUR 606.3 |
VHL (Phospho-Ser68) Polyclonal Conjugated Antibody |
C12654 |
SAB |
100ul |
EUR 476.4 |
VHL Peptide |
45-170P |
ProSci |
0.1 mg |
EUR 405.6 |
Phospho-VHL (S68) Antibody |
1-CSB-PA060066 |
Cusabio |
|
|
Phospho-VHL (Ser68) Antibody |
AF8334 |
Affbiotech |
200ul |
EUR 540 |
VHL (Phospho-Ser68) Antibody |
12654-100ul |
SAB |
100ul |
EUR 302.4 |
VHL (Phospho-Ser68) Antibody |
12654-50ul |
SAB |
50ul |
EUR 224.4 |
Polyclonal VHL / Von Hippel Lindau Antibody (aa34-83) |
APR10721G |
Leading Biology |
0.05ml |
EUR 580.8 |
VHL Blocking Peptide |
DF6104-BP |
Affbiotech |
1mg |
EUR 234 |
VHL Blocking Peptide |
AF6292-BP |
Affbiotech |
1mg |
EUR 234 |
VHL cloning plasmid |
CSB-CL025852HU-10ug |
Cusabio |
10ug |
EUR 306 |
VHL Rabbit pAb |
A11240-100ul |
Abclonal |
100 ul |
EUR 369.6 |
VHL Rabbit pAb |
A11240-200ul |
Abclonal |
200 ul |
EUR 550.8 |
VHL Rabbit pAb |
A11240-20ul |
Abclonal |
20 ul |
EUR 219.6 |
VHL Rabbit pAb |
A11240-50ul |
Abclonal |
50 ul |
EUR 267.6 |
VHL Mouse mAb |
A11872-100ul |
Abclonal |
100 ul |
Ask for price |
VHL Mouse mAb |
A11872-200ul |
Abclonal |
200 ul |
Ask for price |
VHL Mouse mAb |
A11872-20ul |
Abclonal |
20 ul |
Ask for price |
VHL Mouse mAb |
A11872-50ul |
Abclonal |
50 ul |
EUR 318 |
VHL Blocking Peptide |
33R-2312 |
Fitzgerald |
100 ug |
EUR 216 |
VHL Rabbit pAb |
A16287-100ul |
Abclonal |
100 ul |
EUR 369.6 |
VHL Rabbit pAb |
A16287-200ul |
Abclonal |
200 ul |
EUR 550.8 |
Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment
Though autophagy is critical for cell survival underneath stress circumstances, latest research have proven that autophagy can even promote cell demise. On account of the truth that each autophagy induction and Fhit expression are generally related to nutrient hunger, we hypothesized that Fhit expression could also be associated to autophagy induction.
Within the current research, we assessed whether or not Fhit overexpression by gene switch induces autophagy in Fhit-deficient non-small cell lung most cancers (NSCLC) cells. The outcomes of our research point out that Fhit protein induces autophagy in NSCLC cells, and that this autophagy prevents apoptotic cell demise in vivo and in vitro in a 14-3-3τ protein-dependent method. To the perfect of our information, that is the primary report to explain Fhit-induced autophagy. Suppressing autophagy could be a promising therapeutic possibility to reinforce the efficacy of Fhit gene remedy in NSCLC.