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Best tumor suppressor protein

TOPORS, a tumor suppressor protein, contributes to the maintenance of higher-order chromatin architecture.

 

  • Within the nucleus, chromosomes are hierarchically folded into lively (A) and inactive (B) compartments composed of topologically associating domains (TADs). Genomic areas work together with nuclear lamina, termed lamina-associated domains (LADs). Nevertheless, the molecular mechanisms underlying these 3D chromatin architectures stay incompletely understood. Right here, we investigated the function of a possible tumor suppressor, TOP1 Binding Arginine/Serine Wealthy Protein (TOPORS), in genome group.

 

  • In mouse hepatocytes, chromatin interactions between A and B compartments enhance and compartmentalization power is lowered considerably upon Topors knockdown.

 

  • Correspondingly, power of TAD boundaries situated at A/B borders is weakened. Within the absence of TOPORS, chromatin-lamina interactions lower and the protection of LADs reduces from 53.31% to 46.52%. Apparently, these adjustments in 3D genome are related to PML nuclear our bodies and PML-associated domains (PADs).

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment

  • Furthermore, chromatin accessibility is altered predominantly at intergenic regions upon Topors knockdown, together with a subset of enhancers.

 

  • These alterations of chromatin are concordant with transcriptome adjustments, that are related to carcinogenesis. Collectively, our findings demonstrate that TOPORS features as a regulator in chromatin construction, offering novel perception into the architectural roles of tumor suppressors in higher-order genome organization.

 

 

 

Human Von Hippel-Lindau disease tumor suppressor (VHL) ELISA Kit
AE11684HU-96Tests 96 Tests
EUR 610

Human Von Hippel-Lindau disease tumor suppressor (VHL) ELISA Kit
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EUR 280

Human Von Hippel-Lindau disease tumor suppressor (VHL)
1-CSB-EP025852HU
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Human VHL/ Von Hippel-Lindau disease tumor suppressor ELISA Kit
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EUR 515

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EUR 681.12

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ELISA Kit for Von Hippel Lindau Tumor Suppressor (vHL)
SEJ769Ra 96Т
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Rat Von Hippel-Lindau disease tumor suppressor (VHL) ELISA Kit
RK14919 96T
EUR 280

Mouse Von Hippel-Lindau disease tumor suppressor (VHL) ELISA Kit
RK13981 96T
EUR 280

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KBH6401 1 x 96 wells
EUR 286

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
DLR-vHL-Hu 96T
EUR 499

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EKL61493-5x96T 5x96T
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RD-vHL-Hu-48T 48T
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Von Hippel-Lindau Disease Tumor Suppressor (VHL) Protein
20-abx260439
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Von Hippel-Lindau Disease Tumor Suppressor (VHL) Protein
abx260439-10g 10 µg
EUR 325

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Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx431703-200ul 200 ul
EUR 460.8

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Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
20-abx126781
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Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx219331-100ug 100 ug
EUR 526.8

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abx239402-100ug 100 ug
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Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
20-abx137392
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Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx117007-100ug 100 ug
EUR 560.4

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Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
20-abx000699
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Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx032864-400ul 400 ul
EUR 627.6

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abx126781-100l 100 µl
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Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
abx239402-100l 100 µl Ask for price

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abx239402-50l 50 µl
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abx032864-400l 400 µl
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abx431703-200l 200 µl
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ELISA kit for Rat vHL (Von Hippel Lindau Tumor Suppressor)
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Recombinant Human Von Hippel-Lindau disease tumor suppressor (VHL)
CSB-EP025852HU 2480 mg Ask for price

Recombinant Human Von Hippel-Lindau disease tumor suppressor(VHL)
AP77730 1mg
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RPC22221-100ug 100ug
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Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
DLR-vHL-Ra 96T
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EKU08182-48T 48T
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EKU08182-96T 96T
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EKN49293-48T 48T
EUR 375.41

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
EKN49293-5x96T 5x96T
EUR 2547.43

 

  • The gene encoding ‘deleted in breast most cancers 2’ (DBC2), additionally known as RHOBTB2 (Rho-related BTB domain-containing protein 2), is assessed as a tumor suppressor gene. DBC2 is a substrate-specific adaptor protein for a novel class of Cullin-3 (CUL3)-based E3 ubiquitin ligases; nonetheless, it’s unclear if the substrate adaptor operate of DBC2 is required for its tumor suppressor exercise. Moreover, the important thing substrates of DBC2-mediated ubiquitination have but to be recognized.

 

  • Within the current research, we established a genome-wide human cDNA library-based in vitro ubiquitination goal screening assay and recognized Musashi-2 (MSI2) as a novel ubiquitination goal protein of DBC2. MSI2 immediately interacted with DBC2, and this interplay promoted MSI2 polyubiquitination and proteasomal degradation in breast most cancers cells.

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment

  • Overexpression and knockdown experiments demonstrated that DBC2 suppressed MSI2-associated oncogenic features and induced apoptosis.

 

  • Immunohistochemistry evaluation of a breast most cancers tissue microarray revealed that DBC2 and MSI2 protein ranges are inversely correlated in each regular breast tissues and breast most cancers tissues. Taken collectively, these findings present proof that DBC2 suppresses tumorigenesis in breast most cancers by ubiquitinating MSI2.

Fhit, a tumor suppressor protein, induces autophagy via 14-3-3τ in non-small cell lung most cancers cells.

 

 

Von Hippel-Lindau Illness Tumor Suppressor (VHL) Antibody

 

 

Inactivation of the delicate histidine triad (Fhit) gene has been reported within the majority of human cancers, significantly in lung most cancers.

 

The function of Fhit as a tumor suppressor gene has been nicely documented, and restoration of Fhit expression suppresses tumorigenicity in tumor cell traces and in mouse fashions by inducing apoptosis and inhibiting proliferation of tumor cells.

 

Autophagy is a catabolic pathway, whereby cytoplasmic proteins and organelles are sequestered in vacuoles and delivered to lysosomes for degradation and recycling.

 

 

VHL Polyclonal Antibody
46866-100ul 100ul
EUR 302.4

VHL Polyclonal Antibody
46866-50ul 50ul
EUR 224.4

VHL Polyclonal Antibody
ABP56500-003ml 0.03ml
EUR 189.6

VHL Polyclonal Antibody
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ABP60891-02ml 0.2ml
EUR 496.8

VHL Polyclonal Antibody
E44H06396 100ul
EUR 255

VHL Polyclonal Antibody
E44H07430 100ul
EUR 255

VHL Polyclonal Antibody
E-AB-93053-120uL 120uL
EUR 320

VHL Polyclonal Antibody
E-AB-93053-200uL 200uL
EUR 530

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E-AB-93053-60uL 60uL
EUR 200

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E-AB-93053-each each Ask for price

VHL Polyclonal Antibody
E-AB-65684-120uL 120uL
EUR 320

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E-AB-65684-200uL 200uL
EUR 530

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E-AB-65684-60uL 60uL
EUR 200

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E-AB-66748-120uL 120uL
EUR 320

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E-AB-66748-200uL 200uL
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E-AB-66748-60uL 60uL
EUR 200

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VHL Rabbit Polyclonal Antibody
ES7499-100ul 100ul
EUR 124

VHL Rabbit Polyclonal Antibody
ES7499-50ul 50ul
EUR 74

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ES8746-100ul 100ul
EUR 124

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ES8746-50ul 50ul
EUR 74

VHL Rabbit Polyclonal Antibody
54173 100ul
EUR 439

VHL Rabbit Polyclonal Antibody
E10G07702 100 μl
EUR 275

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E10G00779 100 μl
EUR 275

Rabbit Polyclonal VHL Antibody
TA327866 100 µl Ask for price

Goat Polyclonal Antibody against VHL
TA303127 100 µg Ask for price

VHL (phospho Ser68) Polyclonal Antibody
E20-61113 100ug
EUR 225

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ABP56499-003ml 0.03ml
EUR 189.6

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ABP56499-02ml 0.2ml
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E44H00337 100ul
EUR 255

Polyclonal VHL Antibody (C-term)
APR10723G 0.1ml
EUR 580.8

VHL (phospho Ser68) Rabbit Polyclonal Antibody
ES7498-100ul 100ul
EUR 124

VHL (phospho Ser68) Rabbit Polyclonal Antibody
ES7498-50ul 50ul
EUR 74

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody
CAU21658-100ul 100ul
EUR 255.4

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody
CAU21658-200ul 200ul
EUR 319.2

VHL (Phospho-Ser68) Polyclonal Conjugated Antibody
C12654 100ul
EUR 476.4

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat)
4-PAJ769Ra01
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Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), PE
4-PAJ769Ra01-PE
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  • 100ul
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Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), APC
4-PAJ769Ra01-APC
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  • 100ul
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Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), Cy3
4-PAJ769Ra01-Cy3
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  • 100ul
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Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), HRP
4-PAJ769Ra01-HRP
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  • 100ul
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Polyclonal VHL / Von Hippel Lindau Antibody (aa34-83)
APR10721G 0.05ml
EUR 580.8

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), FITC
4-PAJ769Ra01-FITC
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  • 100ul
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Von Hippel Lindau (VHL) (C-term) rabbit polyclonal antibody
AP17826PU-N 400 µl Ask for price

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), Biotinylated
4-PAJ769Ra01-Biotin
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Rabbit anti-VHL Polyclonal Antibody
TA326834 100 µg Ask for price

Anti-VHL Rabbit Polyclonal Antibody
TA321159 100 µl Ask for price

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TA321160 100 µl Ask for price

Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody (Rat), APC-Cy7
4-PAJ769Ra01-APC-Cy7
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  • 100ul
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Polyclonal Antibody to Von Hippel Lindau Tumor Suppressor (vHL)
PAJ769Ra01 100ul
EUR 266

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AMM05157G 0.1 mg
EUR 580.8

VHLL Polyclonal Antibody
A65646
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VHLL Polyclonal Antibody, HRP Conjugated
A65647
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  • 100 µg
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VHLL Polyclonal Antibody, FITC Conjugated
A65648
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  • 100 µg
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VHLL Polyclonal Antibody, Biotin Conjugated
A65649
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  • 100 µg
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Rabbit Anti Human VHL Polyclonal Affinity Purified (PBS with 0.05% sodium azide and 50% glycerol, pH7.4) (IHC,ELISA)
IRBAHUVHLAP671120UL each
EUR 259

Rabbit Anti Human VHL Polyclonal Affinity Purified (PBS with 0.05% sodium azide and 50% glycerol, pH7.4) (IHC,ELISA)
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Polyclonal AntibodyPC1 Polyclonal Antibody
E-AB-65139-120uL 120uL
EUR 320

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EUR 200

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VHL antibody
10R-1029 100 ul
EUR 379.2

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32075 100ul
EUR 439

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32075-100ul 100ul
EUR 302.4

VHL Antibody
1-CSB-PA991849
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VHL Antibody
CSB-PA025852KA01HU- each
EUR 402

VHL Antibody
CSB-PA025852KA01HU-100ul 100ul
EUR 466.8

VHL Antibody
E18-6292-1 50μg/50μl
EUR 145

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VHL Antibody
F49681-0.05ML 0.05 ml
EUR 140.25

VHL Antibody
F49681-0.2ML 0.2 ml
EUR 322.15

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EUR 140.25

VHL Antibody
F49682-0.4ML 0.4 ml
EUR 330.65

VHL Antibody
E312859 200ul
EUR 275

VHL Antibody
E90377 100ul
EUR 255

VHL Antibody
DF6104 200ul
EUR 420

VHL Antibody
DF6104-100ul 100ul
EUR 280

VHL Antibody
DF6104-200ul 200ul
EUR 350

VHL Antibody
AF6292 200ul
EUR 420

VHL Antibody
AF6292-100ul 100ul
EUR 280

VHL Antibody
AF6292-200ul 200ul
EUR 350

 

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment

Though autophagy is critical for cell survival underneath stress circumstances, latest research have proven that autophagy can even promote cell demise. On account of the truth that each autophagy induction and Fhit expression are generally related to nutrient hunger, we hypothesized that Fhit expression could also be associated to autophagy induction.

 

 

Within the current research, we assessed whether or not Fhit overexpression by gene switch induces autophagy in Fhit-deficient non-small cell lung most cancers (NSCLC) cells. The outcomes of our research point out that Fhit protein induces autophagy in NSCLC cells, and that this autophagy prevents apoptotic cell demise in vivo and in vitro in a 14-3-3τ protein-dependent method. To the perfect of our information, that is the primary report to explain Fhit-induced autophagy. Suppressing autophagy could be a promising therapeutic possibility to reinforce the efficacy of Fhit gene remedy in NSCLC.

Ronald

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