Von Hippel-Lindau (VHL) Protein Antagonist VH298 Improves Wound Therapeutic in Streptozotocin-Induced Hyperglycaemic Rats by Activating Hypoxia-Inducible Issue- (HIF-) 1 Signalling.

 

The aim of the current analysis is to analyze the results of the VHL protein antagonist, VH298, on purposeful actions of fibroblasts and vascular endothelial cells and the results on the wound therapeutic course of in a streptozotocin-induced hyperglycaemic rat mannequin.

HIF-1α and hydroxy-HIF-1α protein ranges in VH298-treated rat fibroblasts (rFb) had been measured by immunoblotting, rFb proliferation was detected by the CCK-Eight assay, and mRNA ranges of associated genes had been measured by quantitative RT-PCR. In vitro wound therapeutic was simulated by the scratch take a look at; angiogenesis was measured by the human umbilical vein endothelial cell (hUVEC) tube formation assay. VH298 or PBS was regionally injected into wounds in rat fashions with streptozotocbd tissues had been harvested, and haematoxylin-eosin (HE) and Masson trichrome staining and immunohistochemical processes had been carried out.

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment

HIF-1α and hydroxy-HIF-1α ranges elevated in VH298-treated rFb, in a time- and dose-dependent method. Thirty micromolar VH298 may considerably enhance cell proliferation, angiogenesis, and gene expression of sort I collagen-αα

Taken collectively, VH298 activated the HIF-1 signalling pathway by stabilizing each HIF-1α and hydroxy-HIF-1α. VH298 enhanced rFb capabilities, promoted hUVEC angiogenesis, and accelerated wound therapeutic within the rat mannequin mimicking diabetes mellitus.

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment

 

 

VHL Antibody
ABD6104	Lifescience Market	100 ug	EUR 525.6

VHL Antibody
32075	SAB	100ul	EUR 439

VHL Antibody
32075-100ul	SAB	100ul	EUR 302.4

VHL Antibody
1-CSB-PA071125	Cusabio	Ask for price Ask for price	50ul 100ul
Description: A polyclonal antibody against VHL. Recognizes VHL from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100

VHL Antibody
1-CSB-PA876839	Cusabio	Ask for price Ask for price	50ug 100ug
Description: A polyclonal antibody against VHL. Recognizes VHL from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC-p:1:50-300, ELISA:1:10000-20000

VHL Antibody
CSB-PA025852KA01HU-	Cusabio	each	EUR 402
Description: A polyclonal antibody against VHL. Recognizes VHL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

VHL Antibody
CSB-PA025852KA01HU-100ul	Cusabio	100ul	EUR 466.8
Description: A polyclonal antibody against VHL. Recognizes VHL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

VHL Antibody
CSB-PA025852ZA01HU-02mg	Cusabio	0.2mg	Ask for price
Description: Recombinant Homo sapiens VHL protein

VHL Antibody
CSB-PA025852ZA01HU-10mg	Cusabio	10mg	Ask for price
Description: Recombinant Homo sapiens VHL protein

VHL Antibody
1-CSB-PA060067	Cusabio	Ask for price Ask for price	50ug 100ug
Description: A polyclonal antibody against VHL. Recognizes VHL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/40000

VHL Antibody
B8450-100ul	Assay Biotech	100μl	EUR 217
Description: VHL Rabbit Polyclonal Antibody

VHL Antibody
B8450-50ul	Assay Biotech	50μl	EUR 143.5
Description: VHL Rabbit Polyclonal Antibody

VHL Antibody
AF6292	Affbiotech	200ul	EUR 420

VHL Antibody
AF6292-100ul	Affinity Biosciences	100ul	EUR 168
Description: WB,IHC,ELISA(peptide)

VHL Antibody
AF6292-200ul	Affinity Biosciences	200ul	EUR 210
Description: WB,IHC,ELISA(peptide)

VHL Antibody
C30872-100ul	Assay Biotech	100μl	EUR 217
Description: VHL Rabbit Polyclonal Antibody

VHL Antibody
C30872-50ul	Assay Biotech	50μl	EUR 143.5
Description: VHL Rabbit Polyclonal Antibody

VHL Antibody
DF6104	Affbiotech	200ul	EUR 420

VHL Antibody
DF6104-100ul	Affinity Biosciences	100ul	EUR 168
Description: WB,IHC,ELISA(peptide)

VHL Antibody
DF6104-200ul	Affinity Biosciences	200ul	EUR 210
Description: WB,IHC,ELISA(peptide)

VHL Antibody
1-CSB-PA991849	Cusabio	Ask for price Ask for price	50ul 100ul
Description: A polyclonal antibody against VHL. Recognizes VHL from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:10000, IHC:1:50-1:200

Vhl Antibody
CSB-PA893700XA01DLU-02mg	Cusabio	0.2mg	Ask for price
Description: Recombinant Drosophila melanogaster (Fruit fly) Vhl protein

Vhl Antibody
CSB-PA893700XA01DLU-10mg	Cusabio	10mg	Ask for price
Description: Recombinant Drosophila melanogaster (Fruit fly) Vhl protein

VHL antibody
CAF50371-100ug	Biomatik Corporation	100ug	EUR 338

VHL Antibody
E90377	EnoGene	100ul	EUR 255
Description: Available in various conjugation types.

VHL Antibody
E312859	EnoGene	200ul	EUR 275
Description: Available in various conjugation types.

VHL Antibody
E18-6292-1	EnoGene	50μg/50μl	EUR 145
Description: Available in various conjugation types.

VHL Antibody
E18-6292-2	EnoGene	100μg/100μl	EUR 225
Description: Available in various conjugation types.

VHL Antibody
E19-6104	EnoGene	100μg/100μl	EUR 225
Description: Available in various conjugation types.

VHL Antibody
GWB-MV584H	GenWay Biotech	50ug	Ask for price

VHL Antibody
MBS2526109-006mL	MyBiosource	0.06mL	EUR 230

VHL Antibody
MBS2526109-012mL	MyBiosource	0.12mL	EUR 310

VHL antibody
MBS206608-005mL	MyBiosource	0.05mL	EUR 260

VHL antibody
MBS206608-01mL	MyBiosource	0.1mL	EUR 345

VHL antibody
MBS206608-5x01mL	MyBiosource	5x0.1mL	EUR 1300

VHL Antibody
MBS7124447-005mL	MyBiosource	0.05mL	EUR 190

VHL Antibody
MBS7124447-01mL	MyBiosource	0.1mL	EUR 270

VHL Antibody
MBS7124447-5x01mL	MyBiosource	5x0.1mL	EUR 1205

VHL Antibody
MBS7124448-005mL	MyBiosource	0.05mL	EUR 190

VHL Antibody
MBS7124448-01mL	MyBiosource	0.1mL	EUR 270

VHL Antibody
MBS7124448-5x01mL	MyBiosource	5x0.1mL	EUR 1205

VHL Antibody
MBS7122921-005mg	MyBiosource	0.05mg	EUR 150

VHL Antibody
MBS7122921-01mg	MyBiosource	0.1mg	EUR 190

VHL Antibody
MBS7122921-5x01mg	MyBiosource	5x0.1mg	EUR 845

VHL Antibody
MBS7120828-005mg	MyBiosource	0.05mg	EUR 150

VHL Antibody
MBS7120828-01mg	MyBiosource	0.1mg	EUR 190

VHL Antibody
MBS7120828-5x01mg	MyBiosource	5x0.1mg	EUR 845

VHL Antibody
MBS8503778-01mL	MyBiosource	0.1mL	EUR 325

VHL Antibody
MBS8503778-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

 

 

VHL Dependent Expression of REDD1 and PDK3 Proteins in Clear-cell Renal Cell Carcinoma.

 

 

• Sporadic clear-cell renal cell carcinoma (ccRCC) is related with mutations within the VHL gene, upregulated mammalian goal of rapamycin (mTOR) exercise and glycolytic metabolism. Right here, we analyze the impact of VHL mutational standing on the expression stage of mTOR, eIF4E-BP1, AMPK, REDD1, and PDK3 proteins.

pGF-AP1-mCMV-EF1-Puro (293 secure cell line)

• Complete proteins had been remoted from 21 tumorous samples with biallelic inactivation, 10 with monoallelic inactivation and 6 tumors with a wild-type VHL (wtVHL) gene obtained from sufferers who underwent complete nephrectomy. The expressions of goal proteins had been assessed utilizing Western blot.Expressions of mTOR, eIF4EBP1 and AMPOkay had been VHL impartial.

 

• Tumors with monoallelic inactivation of VHL underexpressed REDD1 compared to wtVHL tumors (P = 0.042), tumors with biallelic VHL inactivation (P < 0.005) and management tissue (P = 0.004). Moreover, REDD1 expression was larger in tumors with VHL biallelic inactivation than in management tissue (P = 0.008). Solely in wt tumor samples PDK3 was overexpressed compared to tumors with biallelic inactivation of VHL gene (P = 0.012) and controls (P = 0.016). In wtVHL ccRCC, multivariate linear regression evaluation revealed that 97.4% of variability in PDK3 expression might be defined by variations in AMPK quantity.Expressions of mTOR, eIF4EBP1 and AMPK had been VHL impartial.

 

• Now we have proven for the primary time VHL dependent expression of PDK3 and we offer extra proof that VHL mutational standing impacts REDD1 expression in sporadic ccRCC.

Gene Knock-Out HR Concentrating on Vector w/Single Choice Marker (Blasticidin) and Destructive Choice (TK) Towards Random Integration

• Von Hippel-Lindau (VHL) illness is a uncommon hereditary most cancers syndrome that reduces life expectancy. We aimed to assemble a extra useful genotype-phenotype correlation primarily based on alterations in VHL protein (pVHL).

 

• VHL sufferers (n = 339) had been recruited and grouped primarily based on mutation sorts: HIF-α binding web site missense (HM) mutations, non-HIF-α binding web site missense (nHM) mutations, and truncating (TR) mutations. Age-related dangers of VHL-associated tumors and affected person survival had been in contrast.

 

• Missense mutations conferred an elevated danger of pheochromocytoma (HR = 1.854, p = 0.047) in contrast with truncating mutations. The danger of pheochromocytoma was decrease within the HM group than within the nHM group (HR = 0.298, p = 0.003) however was related between HM and TR teams (HR = 0.901, p = 0.810).

MUC16 CRISPR Knock Out Human OVCAR3-A1 Cell Line
T6230	ABM	1x10^6 cells / 1.0 ml	Ask for price

CXCL8 CRISPR Knock Out L3.6pl Cell Line
T6220	ABM	1x10^6 cells / 1.0 ml	Ask for price

CXCL1 CRISPR Knock Out L3.6pl Cell Line
T6221	ABM	1x10^6 cells / 1.0 ml	Ask for price

Ccl2 CRISPR Knock Out CT26 Cell Line
T9611	ABM	1x10^6 cells / 1.0 ml	Ask for price

SIRT CRISPR Knock Out Human HepG2 Cell Line - Clone T3-6
T6804	ABM	1x10^6 cells / 1.0 ml	Ask for price

PRSS21 CRISPR Knock Out Human OVCAR8 Cell Line - Clone T2 C8
T6811	ABM	1x10^6 cells / 1.0 ml	Ask for price

TREM2 CRISPR Knock Out Human THP-1 Cell Line - Clone T1-9
T6810	ABM	1x10^6 cells / 1.0 ml	Ask for price

PTPN6 CRISPR Knock Out Human THP-1 Cell Line - Clone T3-1
T6813	ABM	1x10^6 cells / 1.0 ml	Ask for price

mAdrb2 CRISPR Knock Out B16 Cell Line (T1-10)
T9775	ABM	1x10^6 cells / 1.0 ml	Ask for price

MSLN CRISPR Knock Out Human OVCAR3-A1 Cell Line - Clone T2 C4
T6820	ABM	1x10^6 cells / 1.0 ml	Ask for price

NR2F6 CRISPR Knock Out Human Jurkat E6.1 Cell Line - Clone T3-10
T6822	ABM	1x10^6 cells / 1.0 ml	Ask for price

NUAK2 CRISPR Knock Out 293T Cell Line - Clone T3 #41
T6801	ABM	1x10^6 cells / 1.0 ml	Ask for price

Aldh2 CRISPR Knock Out L929 Cell Line - Clone T3-20
T9692	ABM	1x10^6 cells / 1.0 ml	Ask for price

hPIM1 CRISPR Knock Out SACC-83 Cell Line-T3-9
T9787	ABM	1x10^6 cells / 1.0 ml	Ask for price

Dcx CRISPR Knock Out C6 Cell Line (Rat) - Clone sg4-1
T9624	ABM	1x10^6 cells / 1.0 ml	EUR 3950

GLT1 CRISPR Knock Out Rat AST Cell Line - Clone T2-1
T9678	ABM	1x10^6 cells / 1.0 ml	Ask for price

PTPN11 CRISPR Knock Out NIH/3T3 Cell Line - Clone T4-9
T6803	ABM	1x10^6 cells / 1.0 ml	Ask for price

METTL3 CRISPR Knock Out Caki-1 Cell Line - Clone T2-16
T9623	ABM	1x10^6 cells / 1.0 ml	EUR 3950

Nacc1 CRISPR Knock Out ID8 Cell Line (Mouse) - Clone T1-23
T9627	ABM	1x10^6 cells / 1.0 ml	Ask for price

CARMIL1 CRISPR Knock Out Immortalized Human Gingival Fibroblast - hTERT Cell Line - T1-2
T6825	ABM	1x10^6 cells / 1.0 ml	Ask for price

osbpl2 CRISPR Knock Out NIH/3T3 Cell Line - T1 Polyclonal Pool
T9682	ABM	1x10^6 cells / 1.0 ml	Ask for price

Aifm1 CRISPR Knock Out Mouse L929 Cell Line - Clone T2-15-3
T9674	ABM	1x10^6 cells / 1.0 ml	Ask for price

SEC61G CRISPR Knock Out HCC-LM3 Cell Line - Clone T2-17-5
T9746	ABM	1x10^6 cells / 1.0 ml	Ask for price

Cell line gene knock-in and knock-out
S301	101Bio	-	EUR 15000

293/GFP Cell Line
AKR-200	Cell Biolabs	1 vial	EUR 388
Description: Fluorescence

293/Cas9 Cell Line
AKR-5110	Cell Biolabs	1 vial	EUR 460

Human VHL knockdown HAP1 Cell Line
ABC-KD16757	AcceGen	1 vial	Ask for price
Description: This cell line is engineered by our optimized transduction of the specific shRNA with lentivirus

Araf CRISPR Knocked out RAW264.7 Stable cell Cell Line (Mouse) T3-3
T9529	ABM	1x10^6 cells/1.0ml	EUR 3950

Araf CRISPR Knocked out RAW264.7 Stable cell Cell Line (Mouse) T1-19
T9511	ABM	1x10^6 cells / 1.0 ml	EUR 3950

Stable Mouse Myeloid-derived Suppressor-like LAL Knock Out (HD1B) Cell Line
T3187	ABM	1x10^6 cells / 1.0 ml	EUR 3950

BRCA1 CRISPR Stable Knockout Human Fibroblast Cell Line
T6245	ABM	1x10^6 cells / 1.0 ml	EUR 3950

PTPRA CRISPR Knockout Immortalized Human Lung Fibroblast Cell Line
T6827	ABM	1x10^6 cells / 1.0 ml	Ask for price

293AD Cell Line
AD-100	Cell Biolabs	1 vial	EUR 308
Description: N/A

293AAV Cell Line
AAV-100	Cell Biolabs	1 vial	EUR 340
Description: N/A

293LTV Cell Line
LTV-100	Cell Biolabs	1 vial	EUR 340
Description: N/A

293RTV Cell Line
RV-100	Cell Biolabs	1 vial	EUR 340

Human CRISP1 knockout cell line
ABC-KH3569	AcceGen	1 vial	Ask for price
Description: Human CRISP1 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human CRISP2 knockout cell line
ABC-KH3570	AcceGen	1 vial	Ask for price
Description: Human CRISP2 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human CRISP3 knockout cell line
ABC-KH3571	AcceGen	1 vial	Ask for price
Description: Human CRISP3 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Acan CRISPR Knockout RCS Cell Line (Rat)
T3000	ABM	1x10^6 cells / 1.0 ml	Ask for price

Human CRISPLD1 knockout cell line
ABC-KH3572	AcceGen	1 vial	Ask for price
Description: Human CRISPLD1 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human CRISPLD2 knockout cell line
ABC-KH3573	AcceGen	1 vial	Ask for price
Description: Human CRISPLD2 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

T47D/GFP Cell Line
AKR-208	Cell Biolabs	1 vial	EUR 686.4
Description: T47D/GFP Cell Line stably expresses GFP and otherwise exhibits the same characteristics of the parental cell line.

A549/GFP Cell Line
AKR-209	Cell Biolabs	1 vial	EUR 388
Description: Fluorescence

HeLa/GFP Cell Line
AKR-213	Cell Biolabs	1 vial	EUR 388
Description: Fluorescence

HeLa/Cas9 Cell Line
AKR-5111	Cell Biolabs	1 vial	EUR 460

NIH3T3/GFP Cell Line
AKR-214	Cell Biolabs	1 vial	EUR 388
Description: Fluorescence

NIH3T3/Cas9 Cell Line
AKR-5104	Cell Biolabs	1 vial	EUR 460

Human CRISP1 knockdown cell line
ABC-KD3569	AcceGen	1 vial	Ask for price
Description: Human CRISP1 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human CRISP2 knockdown cell line
ABC-KD3570	AcceGen	1 vial	Ask for price
Description: Human CRISP2 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human CRISP3 knockdown cell line
ABC-KD3571	AcceGen	1 vial	Ask for price
Description: Human CRISP3 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human VHLL knockout cell line
ABC-KH16758	AcceGen	1 vial	Ask for price
Description: Human VHLL knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

MCF-7/Luc Cell Line
AKR-234	Cell Biolabs	1 vial	EUR 686.4
Description: MCF-7/Luc Cell Line stably expresses luciferase and otherwise exhibits the same characteristics of the parental cell line.

SKOV-3/Luc Cell Line
AKR-232	Cell Biolabs	1 vial	EUR 686.4
Description: SKOV-3/Luc Cell Line stably expresses luciferase and otherwise exhibits the same characteristics of the parental cell line.

OVCAR-5/RFP Cell Line
AKR-254	Cell Biolabs	1 vial	EUR 686.4
Description: OVCAR-5/RFP Cell Line stably expresses RFP and otherwise exhibits the same characteristics of the parental cell line.

Human CRISPLD1 knockdown cell line
ABC-KD3572	AcceGen	1 vial	Ask for price
Description: Human CRISPLD1 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human CRISPLD2 knockdown cell line
ABC-KD3573	AcceGen	1 vial	Ask for price
Description: Human CRISPLD2 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

TARGATT? Knock-in Mouse Cell Line Generation Kit (Master Cell Line)
AST-7001	Applied StemCell	1 Kit	Ask for price
Description: 6 month

PLN Knock-out Human Induced Pluripotent Stem Cells (Episomal, HFF)
iPS41	ALSTEM	1 Vial	EUR 2268

GFAT1 CRISPR Stable Knockout H1299 Cell Line
T6199	ABM	1x10^6 cells / 1.0 ml	EUR 3950

LRP1 Knock-out Human Induced Pluripotent Stem Cells (Episomal, HFF)
iPS31	ALSTEM	1 Vial	EUR 2268

AFF2 Knock-out Human Induced Pluripotent Stem Cells (Episomal, HFF)
iPS61	ALSTEM	1 Vial	EUR 2268

EDC4 CRISPR Stable Knockout HEK293T Cell Line
T6241	ABM	1x10^6 cells / 1.0 ml	EUR 3950

ABCA7 Knock-out Human Induced Pluripotent Stem Cells (Episomal, HFF)
iPS21	ALSTEM	1 Vial	EUR 2268

KCNK3 Knock-out Human Induced Pluripotent Stem Cells (Episomal, HFF)
iPS51	ALSTEM	1 Vial	EUR 2268

LLGL1 Knock-out Human Induced Pluripotent Stem Cells (Episomal, HFF)
iPS71	ALSTEM	1 Vial	EUR 2268

DJ-1 CRISPR Stable Knockout HeLa Cell Line
T6181	ABM	1x10^6 cells / 1.0 ml	EUR 3950

PDPN CRISPR Stable Knockout COS-7 Cell Line
T6039	ABM	1x10^6 cells / 1.0 ml	EUR 3950

PD-L1 CRISPR Stable Knockout MC38 Cell Line
T6149	ABM	1x10^6 cells / 1.0 ml	EUR 3950

PD-L1 CRISPR Stable Knockout CT26 Cell Line
T6237	ABM	1x10^6 cells / 1.0 ml	EUR 3950

Human VHLL knockdown cell line
ABC-KD16758	AcceGen	1 vial	Ask for price
Description: Human VHLL knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

LIMD1-/- CRISPR Stable Knockout HeLa Cell Line
T6357	ABM	1x10^6 cells / 1.0 ml	EUR 3950

SLC35A1 CRISPR Stable Knockout CHO-S Cell Line
T6040	ABM	1x10^6 cells / 1.0 ml	EUR 3950

CXCL1 & CXCL8 CRISPR Double Knockout L3.6pl Cell Line
T6047	ABM	1x10^6 cells / 1.0 ml	Ask for price

TARGATT? Knock-in iPSC Generation (Master Cell Line)
AST-1100	Applied StemCell	1 vial of 1X10^6 cells	Ask for price
Description: 6 month

AXL CRISPR Stable Knockout HT1080 (1-IV) Cell Line
T6232	ABM	1x10^6 cells / 1.0 ml	EUR 3950

AXL CRISPR Stable Knockout HT1080 (3-II) Cell Line
T6233	ABM	1x10^6 cells / 1.0 ml	EUR 3950

Platinum-E Retroviral Packaging Cell Line, Ecotropic
RV-101	Cell Biolabs	1 vial	EUR 648

Platinum-GP Retroviral Packaging Cell Line, Pantropic
RV-103	Cell Biolabs	1 vial	EUR 648

Platinum-A Retroviral Packaging Cell Line, Amphotropic
RV-102	Cell Biolabs	1 vial	EUR 648

Total Protein - Murine Embryonic Stem Cell Line D3
CBA-305	Cell Biolabs	500 ?g	EUR 414
Description: Isolated from mouse ES-D3 cell line Presented as 500 µg at 1 mg/mL in NP-40 Solubilization Buffer

TARGATT? Knock-in CHO Generation Kit (Master Cell Line)
AST-1200	Applied StemCell	1 Kit	Ask for price
Description: 12 month

TARGATT? Knock-in HEK293 Generation Kit (Master Cell Line)
AST-1300	Applied StemCell	1 Kit	Ask for price
Description: 12 month

PTPN6 Stable Knocked Out THP-1 Cell Line
T6216	ABM	1x10^6 cells / 1.0 ml	EUR 3950

Mouse NACC1 CRISPR Stable Knockout ID8 Cell Line - Clone T1-23
T6826	ABM	1x10^6 cells / 1.0 ml	EUR 3950

Human CRIM1 knockout cell line
ABC-KH3563	AcceGen	1 vial	Ask for price
Description: Human CRIM1 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human CRIP1 knockout cell line
ABC-KH3564	AcceGen	1 vial	Ask for price
Description: Human CRIP1 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human CRIP2 knockout cell line
ABC-KH3565	AcceGen	1 vial	Ask for price
Description: Human CRIP2 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human CRIP3 knockout cell line
ABC-KH3566	AcceGen	1 vial	Ask for price
Description: Human CRIP3 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human CRIPT knockout cell line
ABC-KH3568	AcceGen	1 vial	Ask for price
Description: Human CRIPT knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

×

• Sufferers within the nHM group had the next danger of pheochromocytoma (HR = 3.447, p < 0.001) and decrease dangers of central nervous system hemangioblastoma (CHB) (HR = 0.700, p = 0.045), renal cell carcinoma (HR = 0.610, p = 0.024), and pancreatic tumor (HR = 0.382, p < 0.001) than these within the mixed HM and TR (HMTR) group.

 

• Furthermore, nHM mutations had been independently related to better general survival (HR = 0.345, p = 0.005) and CHB-specific survival (HR = 0.129, p = 0.005) than HMTR mutations.

 

• The modified genotype-phenotype correlation hyperlinks VHL gene mutation, substrate binding web site, and phenotypic range (penetrance and survival), and offers extra correct data for genetic counseling and pathogenesis research.