Top VHL Recombinant Protein For Human

Von Hippel-Lindau (VHLProtein Antagonist VH298 Improves Wound Therapeutic in Streptozotocin-Induced Hyperglycaemic Rats by Activating Hypoxia-Inducible Issue- (HIF-) 1 Signalling.

 

The aim of the current analysis is to analyze the results of the VHL protein antagonist, VH298, on purposeful actions of fibroblasts and vascular endothelial cells and the results on the wound therapeutic course of in a streptozotocin-induced hyperglycaemic rat mannequin.

Strategies

HIF-1α and hydroxy-HIF-1α protein ranges in VH298-treated rat fibroblasts (rFb) had been measured by immunoblotting, rFb proliferation was detected by the CCK-Eight assay, and mRNA ranges of associated genes had been measured by quantitative RT-PCR. In vitro wound therapeutic was simulated by the scratch take a look at; angiogenesis was measured by the human umbilical vein endothelial cell (hUVEC) tube formation assay. VH298 or PBS was regionally injected into wounds in rat fashions with streptozotocbd tissues had been harvested, and haematoxylin-eosin (HE) and Masson trichrome staining and immunohistochemical processes had been carried out.

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment

Outcomes

HIF-1α and hydroxy-HIF-1α ranges elevated in VH298-treated rFb, in a time- and dose-dependent method. Thirty micromolar VH298 may considerably enhance cell proliferation, angiogenesis, and gene expression of sort I collagen-αα

Conclusions

Taken collectively, VH298 activated the HIF-1 signalling pathway by stabilizing each HIF-1α and hydroxy-HIF-1α. VH298 enhanced rFb capabilities, promoted hUVEC angiogenesis, and accelerated wound therapeutic within the rat mannequin mimicking diabetes mellitus.

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment

 

 

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RD-vHL-Hu-48Tests 48 Tests
EUR 557

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RD-vHL-Hu-96Tests 96 Tests
EUR 775

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RD-vHL-Ra-48Tests 48 Tests
EUR 557

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RD-vHL-Ra-96Tests 96 Tests
EUR 775

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RDR-vHL-Hu-48Tests 48 Tests
EUR 583

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RDR-vHL-Hu-96Tests 96 Tests
EUR 811

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RDR-vHL-Ra-48Tests 48 Tests
EUR 583

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RDR-vHL-Ra-96Tests 96 Tests
EUR 811

VHL antibody

70R-9757 50 ug
EUR 467
Description: Affinity purified rabbit polyclonal VHL antibody

VHL antibody

70R-34605 100 ug
EUR 327
Description: Purified Rabbit polyclonal VHL antibody

VHL Antibody

AF6292 200ul
EUR 304
Description: VHL Antibody detects endogenous levels of total VHL.

VHL Antibody

ABF6292 100 ug
EUR 438

VHL Antibody

ABD6104 100 ug
EUR 438

VHL antibody

10R-1029 100 ul
EUR 316
Description: Mouse monoclonal VHL antibody

VHL Antibody

DF6104 200ul
EUR 304
Description: VHL Antibody detects endogenous levels of total VHL.

VHL Antibody

1-CSB-PA060067
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against VHL. Recognizes VHL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/40000

VHL Antibody

1-CSB-PA071125
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against VHL. Recognizes VHL from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100

VHL Antibody

CSB-PA025852KA01HU-
EUR 335
Description: A polyclonal antibody against VHL. Recognizes VHL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

VHL Antibody

CSB-PA025852KA01HU-100ul 100ul
EUR 389
Description: A polyclonal antibody against VHL. Recognizes VHL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

VHL Antibody

1-CSB-PA876839
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against VHL. Recognizes VHL from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC-p:1:50-300, ELISA:1:10000-20000

VHL Antibody

1-CSB-PA991849
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against VHL. Recognizes VHL from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:10000, IHC:1:50-1:200

VHL Antibody

32075-100ul 100ul
EUR 252

VHL/ Rat VHL ELISA Kit

ELA-E1894r 96 Tests
EUR 886

Vhl/ Rat Vhl ELISA Kit

ELI-06080r 96 Tests
EUR 886

Anti-VHL antibody

PAab09402 100 ug
EUR 386

VHL Polyclonal Antibody

ES7499-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against VHL from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

VHL Polyclonal Antibody

ES7499-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against VHL from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

VHL Polyclonal Antibody

ES8746-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against VHL from Human. This antibody is tested and validated for IHC, WB, ELISA

VHL Polyclonal Antibody

ES8746-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against VHL from Human. This antibody is tested and validated for IHC, WB, ELISA

VHL Polyclonal Antibody

ABP60891-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of VHL from Human. This VHL antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human VHL protein at amino acid sequence of 1-50

VHL Polyclonal Antibody

ABP60891-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of VHL from Human. This VHL antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human VHL protein at amino acid sequence of 1-50

VHL Polyclonal Antibody

ABP60891-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of VHL from Human. This VHL antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human VHL protein at amino acid sequence of 1-50

VHL Polyclonal Antibody

ABP56500-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of VHL from Human, Mouse, Rat. This VHL antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human VHL around the non-phosphorylation site of S68

VHL Polyclonal Antibody

ABP56500-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of VHL from Human, Mouse, Rat. This VHL antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human VHL around the non-phosphorylation site of S68

VHL Polyclonal Antibody

ABP56500-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of VHL from Human, Mouse, Rat. This VHL antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human VHL around the non-phosphorylation site of S68

VHL (pS68) Antibody

abx219320-100ug 100 ug
EUR 439

Anti-VHL antibody

STJ26089 100 µl
EUR 277
Description: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Anti-VHL antibody

STJ98809 200 µl
EUR 197
Description: Rabbit polyclonal to VHL.

Anti-VHL antibody

STJ96241 200 µl
EUR 197
Description: Rabbit polyclonal to VHL.

Anti-VHL Antibody

STJ502735 100 µg
EUR 476

Anti-VHL antibody

STJ70964 100 µg
EUR 359

Human VHL Antibody

32825-05111 150 ug
EUR 261

Anti-VHL antibody

STJ118733 100 µl
EUR 277

Anti-VHL antibody

STJ113440 50 µl
EUR 277
Description: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Anti-VHL antibody

STJ113742 100 µl
EUR 277
Description: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

VHL Polyclonal Antibody

46866-100ul 100ul
EUR 252

VHL Polyclonal Antibody

46866-50ul 50ul
EUR 187

VHL Conjugated Antibody

C32075 100ul
EUR 397

anti- VHL antibody

FNab10175 100µg
EUR 505.25
Description: Antibody raised against VHL

 

 

VHL Dependent Expression of REDD1 and PDK3 Proteins in Clear-cell Renal Cell Carcinoma.

 

 

  • Sporadic clear-cell renal cell carcinoma (ccRCC) is related with mutations within the VHL gene, upregulated mammalian goal of rapamycin (mTOR) exercise and glycolytic metabolism. Right here, we analyze the impact of VHL mutational standing on the expression stage of mTOR, eIF4E-BP1, AMPK, REDD1, and PDK3 proteins.

pGF-AP1-mCMV-EF1-Puro (293 secure cell line)

  • Complete proteins had been remoted from 21 tumorous samples with biallelic inactivation, 10 with monoallelic inactivation and 6 tumors with a wild-type VHL (wtVHL) gene obtained from sufferers who underwent complete nephrectomy. The expressions of goal proteins had been assessed utilizing Western blot.Expressions of mTOR, eIF4EBP1 and AMPOkay had been VHL impartial.

 

  • Tumors with monoallelic inactivation of VHL underexpressed REDD1 compared to wtVHL tumors (P = 0.042), tumors with biallelic VHL inactivation (P < 0.005) and management tissue (P = 0.004). Moreover, REDD1 expression was larger in tumors with VHL biallelic inactivation than in management tissue (P = 0.008). Solely in wt tumor samples PDK3 was overexpressed compared to tumors with biallelic inactivation of VHL gene (P = 0.012) and controls (P = 0.016). In wtVHL ccRCC, multivariate linear regression evaluation revealed that 97.4% of variability in PDK3 expression might be defined by variations in AMPK quantity.Expressions of mTOR, eIF4EBP1 and AMPK had been VHL impartial.

 

  • Now we have proven for the primary time VHL dependent expression of PDK3 and we offer extra proof that VHL mutational standing impacts REDD1 expression in sporadic ccRCC.

Gene Knock-Out HR Concentrating on Vector w/Single Choice Marker (Blasticidin) and Destructive Choice (TK) Towards Random Integration

  • Von Hippel-Lindau (VHL) illness is a uncommon hereditary most cancers syndrome that reduces life expectancy. We aimed to assemble a extra useful genotype-phenotype correlation primarily based on alterations in VHL protein (pVHL).

 

  • VHL sufferers (n = 339) had been recruited and grouped primarily based on mutation sorts: HIF-α binding web site missense (HM) mutations, non-HIF-α binding web site missense (nHM) mutations, and truncating (TR) mutations. Age-related dangers of VHL-associated tumors and affected person survival had been in contrast.

 

  • Missense mutations conferred an elevated danger of pheochromocytoma (HR = 1.854, p = 0.047) in contrast with truncating mutations. The danger of pheochromocytoma was decrease within the HM group than within the nHM group (HR = 0.298, p = 0.003) however was related between HM and TR teams (HR = 0.901, p = 0.810).

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RDR-vHL-Hu-48Tests 48 Tests
EUR 583

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RDR-vHL-Hu-96Tests 96 Tests
EUR 811

Gene Knock-Out HR Targeting Vector [MCS1-EF1?-RFP-T2A-Puro-pA-MCS2]

HR110PA-1 10 ug
EUR 1023

Gene Knock-Out HR Targeting Vector [MCS1-EF1a-GFP-T2A-Puro-pA-MCS2]

HR410PA-1 10 ug
EUR 1023

Gene Knock-Out HR Targeting Vector [MCS1-EF1a-RFP-T2A-Hygro-pA-MCS2]

HR510PA-1 10 ug
EUR 1023

TARGATT? Knock-in iPSC Generation (Master Cell Line)

AST-1100 1 vial of 1X10^6 cells Ask for price
Description: 6 month

TARGATT? Knock-in Mouse Cell Line Generation Kit (Master Cell Line)

AST-7001 1 Kit Ask for price
Description: 6 month

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

DLR-vHL-Ra-48T 48T
EUR 549
Description: A sandwich quantitative ELISA assay kit for detection of Rat Von Hippel Lindau Tumor Suppressor (vHL) in samples from tissue homogenates or other biological fluids.

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

DLR-vHL-Ra-96T 96T
EUR 718
Description: A sandwich quantitative ELISA assay kit for detection of Rat Von Hippel Lindau Tumor Suppressor (vHL) in samples from tissue homogenates or other biological fluids.

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RD-vHL-Ra-48Tests 48 Tests
EUR 557

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RD-vHL-Ra-96Tests 96 Tests
EUR 775

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RDR-vHL-Ra-48Tests 48 Tests
EUR 583

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

RDR-vHL-Ra-96Tests 96 Tests
EUR 811

Vhl 3'UTR Luciferase Stable Cell Line

TU121762 1.0 ml Ask for price

VHL 3'UTR GFP Stable Cell Line

TU078117 1.0 ml
EUR 1521

Vhl 3'UTR GFP Stable Cell Line

TU171762 1.0 ml Ask for price

Vhl 3'UTR Luciferase Stable Cell Line

TU223038 1.0 ml Ask for price

VHL 3'UTR Luciferase Stable Cell Line

TU028117 1.0 ml
EUR 1521

Vhl 3'UTR GFP Stable Cell Line

TU273038 1.0 ml Ask for price

TARGATT? Knock-in CHO Generation Kit (Master Cell Line)

AST-1200 1 Kit Ask for price
Description: 12 month

TARGATT? Knock-in HEK293 Generation Kit (Master Cell Line)

AST-1300 1 Kit Ask for price
Description: 12 month

293LTV Cell Line

LTV-100 1 vial
EUR 508
Description: The 293LTV Cell Line is derived from the parental 293 cells but selected for attributes that increase lentiviral production, including fimrer attachment and larger surface area.

293AD Cell Line

AD-100 1 vial
EUR 461
Description: The 293AD Cell Line is derived from the parental 293 cells but selected for attributes that increase adenovirus production, including firmer attachment and larger surface area.

293AAV Cell Line

AAV-100 1 vial
EUR 508
Description: The 293AAV Cell Line is derived from the parental 293 cells but selected for attributes that increase AAV production, including firmer attachment and larger surface area.

293RTV Cell Line

RV-100 1 vial
EUR 508
Description: The 293RTV Cell Line is derived from the parental 293 cells but selected for attributes that increase retroviral production, including fimrer attachment and larger surface area.

Basic HR Targeting Vector [MCS1-LoxP-MCS2-MCS3-pA-LoxP-MCS4] for Gene Knock-In/Out

HR100PA-1 10 ug
EUR 938

T47D/GFP Cell Line

AKR-208 1 vial
EUR 572
Description: T47D/GFP Cell Line stably expresses GFP and otherwise exhibits the same characteristics of the parental cell line.

A549/GFP Cell Line

AKR-209 1 vial
EUR 572
Description: A549/GFP Cell Line stably expresses GFP and otherwise exhibits the same characteristics of the parental cell line.

HeLa/GFP Cell Line

AKR-213 1 vial
EUR 572
Description: HeLa/GFP Cell Line stably expresses GFP and otherwise exhibits the same characteristics of the parental cell line.

NIH3T3/GFP Cell Line

AKR-214 1 vial
EUR 572
Description: NIH3T3/GFP Cell Line stably expresses GFP and otherwise exhibits the same characteristics of the parental cell line.

NIH3T3/Cas9 Cell Line

AKR-5104 1 vial
EUR 572

HeLa/Cas9 Cell Line

AKR-5111 1 vial
EUR 572

VHL/ Rat VHL ELISA Kit

ELA-E1894r 96 Tests
EUR 886

Vhl/ Rat Vhl ELISA Kit

ELI-06080r 96 Tests
EUR 886

Human VHL Antibody

32825-05111 150 ug
EUR 261

Recombinant human VHL

P2120 100ug Ask for price
Description: Recombinant protein for human VHL

Mouse pre-microRNA Expression Construct mir-293+294+295

MMIR-293-295-PA-CL Bacterial Streak
EUR 968

Microplate Swing-Out Centrifuge

abx725026-1Unit 1 Unit
EUR 1476

Clinical Swing-Out Centrifuge

abx725027-1Unit 1 Unit
EUR 1476

SKOV-3/Luc Cell Line

AKR-232 1 vial
EUR 572
Description: SKOV-3/Luc Cell Line stably expresses luciferase and otherwise exhibits the same characteristics of the parental cell line.

MCF-7/Luc Cell Line

AKR-234 1 vial
EUR 572
Description: MCF-7/Luc Cell Line stably expresses luciferase and otherwise exhibits the same characteristics of the parental cell line.

OVCAR-5/RFP Cell Line

AKR-254 1 vial
EUR 572
Description: OVCAR-5/RFP Cell Line stably expresses RFP and otherwise exhibits the same characteristics of the parental cell line.

VHL sgRNA CRISPR Lentivector set (Human)

K2611301 3 x 1.0 ug
EUR 339

Gene Knock-Out HR Targeting Vector w/Single Selection Marker (Blasticidin) and Negative Selection (TK) Against Random Integration

HR720PA-1 10 µg
EUR 1145

VHL antibody

70R-9757 50 ug
EUR 467
Description: Affinity purified rabbit polyclonal VHL antibody

VHL antibody

70R-34605 100 ug
EUR 327
Description: Purified Rabbit polyclonal VHL antibody

VHL Antibody

AF6292 200ul
EUR 304
Description: VHL Antibody detects endogenous levels of total VHL.

VHL Antibody

ABF6292 100 ug
EUR 438

VHL Antibody

ABD6104 100 ug
EUR 438

VHL antibody

10R-1029 100 ul
EUR 316
Description: Mouse monoclonal VHL antibody

VHL Antibody

DF6104 200ul
EUR 304
Description: VHL Antibody detects endogenous levels of total VHL.

VHL Antibody

1-CSB-PA060067
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against VHL. Recognizes VHL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/40000

VHL Antibody

1-CSB-PA071125
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against VHL. Recognizes VHL from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100

VHL Antibody

CSB-PA025852KA01HU-
EUR 335
Description: A polyclonal antibody against VHL. Recognizes VHL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

VHL Antibody

CSB-PA025852KA01HU-100ul 100ul
EUR 389
Description: A polyclonal antibody against VHL. Recognizes VHL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

VHL Antibody

1-CSB-PA876839
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against VHL. Recognizes VHL from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC-p:1:50-300, ELISA:1:10000-20000

VHL Antibody

1-CSB-PA991849
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against VHL. Recognizes VHL from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:10000, IHC:1:50-1:200

VHL siRNA

20-abx939411
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

VHL siRNA

20-abx939412
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

VHL Antibody

32075-100ul 100ul
EUR 252

VHL siRNA

20-abx906024
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

pGF-AP1-mCMV-EF1-Puro (293 stable cell line)

TR201a-p >2 x 10^6 cells
EUR 3263

pGF-CREB-mCMV-EF1-Puro (293 stable cell line)

TR202a-p >2 x 10^6 cells
EUR 3263

pGF-EGR1-mCMV-EF1-Puro (293 stable cell line)

TR204a-p >2 x 10^6 cells
EUR 3263

NF-kB/293/GFP-Luc Transcriptional Reporter Cell Line

TR860A-1 >2 x 10^6 cells
EUR 3263

Human VHL ELISA Kit

ELA-E1894h 96 Tests
EUR 824

VHL ELISA KIT|Human

EF006088 96 Tests
EUR 689

VHL Recombinant Protein (Human)

RP034324 100 ug Ask for price

Human VHL shRNA Plasmid

20-abx955082
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Gene Knock-Out HR Targeting Vector w/Dual Selection Markers (GFP+Puro) and Negative Selection (TK) Against Random Integration

HR700PA-1 10 µg
EUR 1145

Gene Knock-Out HR Targeting Vector w/Dual Selection Markers (RFP+Hygro) and Negative Selection (TK) Against Random Integration

HR710PA-1 10 µg
EUR 1145

Platinum-E Retroviral Packaging Cell Line, Ecotropic

RV-101 1 vial
EUR 920
Description: Conventional cells used for retrovirus packaging, such as those based on NIH3T3 cells, have limited stability and produce relatively low yields of retrovirus, mainly due to the poor expression of retroviral structure proteins (gag, pol and env) in the cells. The Platinum Retroviral Packaging Cell Lines are based on the 293T cell line. They exhibit longer stability and produce higher yields of retroviral structure proteins. Plat-E cells contain gag, pol and env genes, allowing retroviral packaging with a single plasmid transfection.

Platinum-A Retroviral Packaging Cell Line, Amphotropic

RV-102 1 vial
EUR 920
Description: Conventional cells used for retrovirus packaging, such as those based on NIH3T3 cells, have limited stability and produce relatively low yields of retrovirus, mainly due to the poor expression of retroviral structure proteins (gag, pol and env) in the cells. The Platinum Retroviral Packaging Cell Lines are based on the 293T cell line. They exhibit longer stability and produce higher yields of retroviral structure proteins. Plat-A cells contain gag, pol and env genes, allowing retroviral packaging with a single plasmid transfection.

Platinum-GP Retroviral Packaging Cell Line, Pantropic

RV-103 1 vial
EUR 920
Description: Conventional cells used for retrovirus packaging, such as those based on NIH3T3 cells, have limited stability and produce relatively low yields of retrovirus, mainly due to the poor expression of retroviral structure proteins (gag, pol and env) in the cells. The Platinum Retroviral Packaging Cell Lines are based on the 293T cell line. They exhibit longer stability and produce higher yields of retroviral structure proteins. Plat-GP cells contain the gag and pol genes required for retroviral packaging; an expression vector is co-transfected with a VSVG envelope vector.

VHL sgRNA CRISPR Lentivector (Human) (Target 1)

K2611302 1.0 ug DNA
EUR 154

VHL sgRNA CRISPR Lentivector (Human) (Target 2)

K2611303 1.0 ug DNA
EUR 154

VHL sgRNA CRISPR Lentivector (Human) (Target 3)

K2611304 1.0 ug DNA
EUR 154

PIK-293

B1658-25
EUR 800

PIK-293

B1658-5
EUR 240

BAY-293

HY-114398 50mg
EUR 1955

PIK-293

E1KS2207 5mg
EUR 599

PIK-293

B2187-10 10 mg
EUR 440
Description: PIK-293 is a PI3K inhibitor, mostly for PI3K? with IC50 of 0.24 ?M, 500-, 100- and 50-fold less potent to PI3K?/?/?, respectively.

PIK-293

B2187-25 25 mg
EUR 902
Description: PIK-293 is a PI3K inhibitor, mostly for PI3K? with IC50 of 0.24 ?M, 500-, 100- and 50-fold less potent to PI3K?/?/?, respectively.

PIK-293

B2187-5 5 mg
EUR 270
Description: PIK-293 is a PI3K inhibitor, mostly for PI3K? with IC50 of 0.24 ?M, 500-, 100- and 50-fold less potent to PI3K?/?/?, respectively.

IBC 293

B7069-10 10 mg
EUR 197

IBC 293

B7069-5.1 10 mM (in 1mL DMSO)
EUR 108

IBC 293

B7069-50 50 mg
EUR 669

Total Protein - Murine Embryonic Stem Cell Line D3

CBA-305 500 ?g
EUR 345
Description:
  • Isolated from mouse ES-D3 cell line
  • Presented as 500 µg at 1 mg/mL in NP-40 Solubilization Buffer

Gene Knock-Out HR Targeting Vector with TK selection [MCS1-LoxP-EF1?-GFP-T2A-Puro-P2A-hsvTK-pA-LoxP-MCS2]

HR210PA-1 10 ug
EUR 1145

VHL Blocking Peptide

AF6292-BP 1mg
EUR 195

  • Sufferers within the nHM group had the next danger of pheochromocytoma (HR = 3.447, p < 0.001) and decrease dangers of central nervous system hemangioblastoma (CHB) (HR = 0.700, p = 0.045), renal cell carcinoma (HR = 0.610, p = 0.024), and pancreatic tumor (HR = 0.382, p < 0.001) than these within the mixed HM and TR (HMTR) group.

 

  • Furthermore, nHM mutations had been independently related to better general survival (HR = 0.345, p = 0.005) and CHB-specific survival (HR = 0.129, p = 0.005) than HMTR mutations.

 

  • The modified genotype-phenotype correlation hyperlinks VHL gene mutation, substrate binding web site, and phenotypic range (penetrance and survival), and offers extra correct data for genetic counseling and pathogenesis research.

 

Leave A Comment