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Top VHL Recombinant Protein For Human

Von Hippel-Lindau (VHL) Protein Antagonist VH298 Improves Wound Therapeutic in Streptozotocin-Induced Hyperglycaemic Rats by Activating Hypoxia-Inducible Issue- (HIF-) 1 Signalling.

 

The aim of the current analysis is to analyze the results of the VHL protein antagonist, VH298, on purposeful actions of fibroblasts and vascular endothelial cells and the results on the wound therapeutic course of in a streptozotocin-induced hyperglycaemic rat mannequin.

Strategies

HIF-1α and hydroxy-HIF-1α protein ranges in VH298-treated rat fibroblasts (rFb) had been measured by immunoblotting, rFb proliferation was detected by the CCK-Eight assay, and mRNA ranges of associated genes had been measured by quantitative RT-PCR. In vitro wound therapeutic was simulated by the scratch take a look at; angiogenesis was measured by the human umbilical vein endothelial cell (hUVEC) tube formation assay. VH298 or PBS was regionally injected into wounds in rat fashions with streptozotocbd tissues had been harvested, and haematoxylin-eosin (HE) and Masson trichrome staining and immunohistochemical processes had been carried out.

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment

Outcomes

HIF-1α and hydroxy-HIF-1α ranges elevated in VH298-treated rFb, in a time- and dose-dependent method. Thirty micromolar VH298 may considerably enhance cell proliferation, angiogenesis, and gene expression of sort I collagen-αα

Conclusions

Taken collectively, VH298 activated the HIF-1 signalling pathway by stabilizing each HIF-1α and hydroxy-HIF-1α. VH298 enhanced rFb capabilities, promoted hUVEC angiogenesis, and accelerated wound therapeutic within the rat mannequin mimicking diabetes mellitus.

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Equipment

 

 

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Hu-48Tests 48 Tests
EUR 668.4

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Hu-96Tests 96 Tests
EUR 930

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Ra-48Tests 48 Tests
EUR 668.4

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Ra-96Tests 96 Tests
EUR 930

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Hu-48Tests 48 Tests
EUR 699.6

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Hu-96Tests 96 Tests
EUR 973.2

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Ra-48Tests 48 Tests
EUR 699.6

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Ra-96Tests 96 Tests
EUR 973.2

VHL Antibody
1-CSB-PA071125
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against VHL. Recognizes VHL from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100

VHL Antibody
1-CSB-PA060067
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against VHL. Recognizes VHL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/40000

VHL Antibody
1-CSB-PA991849
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against VHL. Recognizes VHL from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:10000, IHC:1:50-1:200

VHL Antibody
DF6104 200ul
EUR 420

VHL Antibody
AF6292 200ul
EUR 420

VHL Antibody
1-CSB-PA876839
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against VHL. Recognizes VHL from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC-p:1:50-300, ELISA:1:10000-20000

VHL Antibody
CSB-PA025852KA01HU-100ul 100ul
EUR 466.8
Description: A polyclonal antibody against VHL. Recognizes VHL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

VHL antibody
70R-34605 100 ug
EUR 392.4
Description: Purified Rabbit polyclonal VHL antibody

VHL antibody
70R-9757 50 ug
EUR 560.4
Description: Affinity purified rabbit polyclonal VHL antibody

VHL Antibody
32075-100ul 100ul
EUR 302.4

VHL antibody
10R-1029 100 ul
EUR 379.2
Description: Mouse monoclonal VHL antibody

VHL Antibody
ABF6292 100 ug
EUR 525.6

VHL Antibody
ABD6104 100 ug
EUR 525.6

VHL Antibody
R35773-100UG 100 ug
EUR 399

VHL Antibody
CSB-PA025852KA01HU- each
EUR 402
Description: A polyclonal antibody against VHL. Recognizes VHL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

VHL Antibody
F49681-0.05ML 0.05 ml
EUR 165

VHL Antibody
F49681-0.2ML 0.2 ml
EUR 379

VHL Antibody
F49682-0.08ML 0.08 ml
EUR 165

VHL Antibody
F49682-0.4ML 0.4 ml
EUR 389

VHL/ Rat VHL ELISA Kit
ELA-E1894r 96 Tests
EUR 1063.2

Vhl/ Rat Vhl ELISA Kit
ELI-06080r 96 Tests
EUR 1063.2

VHL Conjugated Antibody
C32075 100ul
EUR 476.4

VHL Polyclonal Antibody
ES7499-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against VHL from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

VHL Polyclonal Antibody
ES7499-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against VHL from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

VHL Polyclonal Antibody
ES8746-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against VHL from Human. This antibody is tested and validated for IHC, WB, ELISA

VHL Polyclonal Antibody
ES8746-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against VHL from Human. This antibody is tested and validated for IHC, WB, ELISA

VHL Polyclonal Antibody
46866-100ul 100ul
EUR 302.4

VHL Polyclonal Antibody
46866-50ul 50ul
EUR 224.4

Human VHL Antibody
32825-05111 150 ug
EUR 313.2

VHL Polyclonal Antibody
ABP56500-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of VHL from Human, Mouse, Rat. This VHL antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human VHL around the non-phosphorylation site of S68

VHL Polyclonal Antibody
ABP56500-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of VHL from Human, Mouse, Rat. This VHL antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human VHL around the non-phosphorylation site of S68

VHL Polyclonal Antibody
ABP56500-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of VHL from Human, Mouse, Rat. This VHL antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human VHL around the non-phosphorylation site of S68

VHL Polyclonal Antibody
ABP60891-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of VHL from Human. This VHL antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human VHL protein at amino acid sequence of 1-50

VHL Polyclonal Antibody
ABP60891-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of VHL from Human. This VHL antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human VHL protein at amino acid sequence of 1-50

VHL Polyclonal Antibody
ABP60891-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of VHL from Human. This VHL antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human VHL protein at amino acid sequence of 1-50

VHL (pS68) Antibody
abx219320-100ug 100 ug
EUR 526.8

anti- VHL antibody
FNab09402 100µg
EUR 658.5
Description: Antibody raised against VHL

anti- VHL antibody
FNab10175 100µg
EUR 606.3
Description: Antibody raised against VHL

Anti-VHL antibody
PAab09402 100 ug
EUR 463.2

Anti-VHL antibody
STJ113440 50 µl
EUR 332.4
Description: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Anti-VHL antibody
STJ113742 100 µl
EUR 332.4
Description: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

 

 

VHL Dependent Expression of REDD1 and PDK3 Proteins in Clear-cell Renal Cell Carcinoma.

 

 

  • Sporadic clear-cell renal cell carcinoma (ccRCC) is related with mutations within the VHL gene, upregulated mammalian goal of rapamycin (mTOR) exercise and glycolytic metabolism. Right here, we analyze the impact of VHL mutational standing on the expression stage of mTOR, eIF4E-BP1, AMPK, REDD1, and PDK3 proteins.

pGF-AP1-mCMV-EF1-Puro (293 secure cell line)

  • Complete proteins had been remoted from 21 tumorous samples with biallelic inactivation, 10 with monoallelic inactivation and 6 tumors with a wild-type VHL (wtVHL) gene obtained from sufferers who underwent complete nephrectomy. The expressions of goal proteins had been assessed utilizing Western blot.Expressions of mTOR, eIF4EBP1 and AMPOkay had been VHL impartial.

 

  • Tumors with monoallelic inactivation of VHL underexpressed REDD1 compared to wtVHL tumors (P = 0.042), tumors with biallelic VHL inactivation (P < 0.005) and management tissue (P = 0.004). Moreover, REDD1 expression was larger in tumors with VHL biallelic inactivation than in management tissue (P = 0.008). Solely in wt tumor samples PDK3 was overexpressed compared to tumors with biallelic inactivation of VHL gene (P = 0.012) and controls (P = 0.016). In wtVHL ccRCC, multivariate linear regression evaluation revealed that 97.4% of variability in PDK3 expression might be defined by variations in AMPK quantity.Expressions of mTOR, eIF4EBP1 and AMPK had been VHL impartial.

 

  • Now we have proven for the primary time VHL dependent expression of PDK3 and we offer extra proof that VHL mutational standing impacts REDD1 expression in sporadic ccRCC.

Gene Knock-Out HR Concentrating on Vector w/Single Choice Marker (Blasticidin) and Destructive Choice (TK) Towards Random Integration

  • Von Hippel-Lindau (VHL) illness is a uncommon hereditary most cancers syndrome that reduces life expectancy. We aimed to assemble a extra useful genotype-phenotype correlation primarily based on alterations in VHL protein (pVHL).

 

  • VHL sufferers (n = 339) had been recruited and grouped primarily based on mutation sorts: HIF-α binding web site missense (HM) mutations, non-HIF-α binding web site missense (nHM) mutations, and truncating (TR) mutations. Age-related dangers of VHL-associated tumors and affected person survival had been in contrast.

 

  • Missense mutations conferred an elevated danger of pheochromocytoma (HR = 1.854, p = 0.047) in contrast with truncating mutations. The danger of pheochromocytoma was decrease within the HM group than within the nHM group (HR = 0.298, p = 0.003) however was related between HM and TR teams (HR = 0.901, p = 0.810).

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Hu-48Tests 48 Tests
EUR 699.6

Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Hu-96Tests 96 Tests
EUR 973.2

Gene Knock-Out HR Targeting Vector [MCS1-EF1?-RFP-T2A-Puro-pA-MCS2]
HR110PA-1 10 ug
EUR 1227.6

Gene Knock-Out HR Targeting Vector [MCS1-EF1a-GFP-T2A-Puro-pA-MCS2]
HR410PA-1 10 ug
EUR 1227.6

Gene Knock-Out HR Targeting Vector [MCS1-EF1a-RFP-T2A-Hygro-pA-MCS2]
HR510PA-1 10 ug
EUR 1227.6

TARGATT? Knock-in iPSC Generation (Master Cell Line)
AST-1100 1 vial of 1X10^6 cells Ask for price
Description: 6 month

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
DLR-vHL-Ra-48T 48T
EUR 658.8
Description: A sandwich quantitative ELISA assay kit for detection of Rat Von Hippel Lindau Tumor Suppressor (vHL) in samples from tissue homogenates or other biological fluids.

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
DLR-vHL-Ra-96T 96T
EUR 861.6
Description: A sandwich quantitative ELISA assay kit for detection of Rat Von Hippel Lindau Tumor Suppressor (vHL) in samples from tissue homogenates or other biological fluids.

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Ra-48Tests 48 Tests
EUR 668.4

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RD-vHL-Ra-96Tests 96 Tests
EUR 930

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Ra-48Tests 48 Tests
EUR 699.6

Rat Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit
RDR-vHL-Ra-96Tests 96 Tests
EUR 973.2

TARGATT? Knock-in Mouse Cell Line Generation Kit (Master Cell Line)
AST-7001 1 Kit Ask for price
Description: 6 month

TARGATT? Knock-in CHO Generation Kit (Master Cell Line)
AST-1200 1 Kit Ask for price
Description: 12 month

TARGATT? Knock-in HEK293 Generation Kit (Master Cell Line)
AST-1300 1 Kit Ask for price
Description: 12 month

CFTR - HEK 293 Cell Line
60506 2 vials
EUR 7500
Description: The CFTR HEK293 Cell Line expresses full length, wild-type human cystic fibrosis transmembrane conductance regulator (CFTR) protein (Genbank #P13569, NP_000483.3), with a C-terminal Streptavidin-Binding Peptide (SBP) tag.Expression must be induced ≥24 hours prior to an experiment using 1 µg/ml Doxycycline and 3 mM Na-butyrate. The inducible expression of CFTR was confirmed by Western blotting and flow cytometry.

VHL 3'UTR GFP Stable Cell Line
TU078117 1.0 ml
EUR 1825.2

Vhl 3'UTR GFP Stable Cell Line
TU273038 1.0 ml Ask for price

Vhl 3'UTR GFP Stable Cell Line
TU171762 1.0 ml Ask for price

Vhl 3'UTR Luciferase Stable Cell Line
TU223038 1.0 ml Ask for price

Vhl 3'UTR Luciferase Stable Cell Line
TU121762 1.0 ml Ask for price

VHL 3'UTR Luciferase Stable Cell Line
TU028117 1.0 ml
EUR 1825.2

Basic HR Targeting Vector [MCS1-LoxP-MCS2-MCS3-pA-LoxP-MCS4] for Gene Knock-In/Out
HR100PA-1 10 ug
EUR 1125.6

Human VHL Antibody
32825-05111 150 ug
EUR 313.2

Recombinant human VHL
P2120 100ug Ask for price
Description: Recombinant protein for human VHL

Vhl/ Rat Vhl ELISA Kit
ELI-06080r 96 Tests
EUR 1063.2

VHL/ Rat VHL ELISA Kit
ELA-E1894r 96 Tests
EUR 1063.2

VHL sgRNA CRISPR Lentivector set (Human)
K2611301 3 x 1.0 ug
EUR 406.8

VHL antibody
70R-34605 100 ug
EUR 392.4
Description: Purified Rabbit polyclonal VHL antibody

VHL Antibody
32075-100ul 100ul
EUR 302.4

VHL Peptide
45-170P 0.1 mg
EUR 405.6
Description: (IN) VHL Peptide

VHL antibody
10R-1029 100 ul
EUR 379.2
Description: Mouse monoclonal VHL antibody

VHL Antibody
ABF6292 100 ug
EUR 525.6

VHL Antibody
ABD6104 100 ug
EUR 525.6

VHL siRNA
20-abx906024
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

VHL antibody
70R-9757 50 ug
EUR 560.4
Description: Affinity purified rabbit polyclonal VHL antibody

VHL Antibody
1-CSB-PA876839
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against VHL. Recognizes VHL from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC-p:1:50-300, ELISA:1:10000-20000

VHL Antibody
1-CSB-PA071125
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against VHL. Recognizes VHL from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100

VHL Antibody
1-CSB-PA060067
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against VHL. Recognizes VHL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/40000

VHL Antibody
1-CSB-PA991849
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against VHL. Recognizes VHL from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:10000, IHC:1:50-1:200

VHL Antibody
DF6104 200ul
EUR 420

VHL siRNA
20-abx939411
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

VHL siRNA
20-abx939412
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

VHL Antibody
AF6292 200ul
EUR 420

VHL Antibody
CSB-PA025852KA01HU-100ul 100ul
EUR 466.8
Description: A polyclonal antibody against VHL. Recognizes VHL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

VHL Antibody
R35773-100UG 100 ug
EUR 399

VHL Antibody
F49681-0.05ML 0.05 ml
EUR 165

VHL Antibody
F49681-0.2ML 0.2 ml
EUR 379

VHL Antibody
F49682-0.08ML 0.08 ml
EUR 165

VHL Antibody
F49682-0.4ML 0.4 ml
EUR 389

VHL Antibody
CSB-PA025852KA01HU- each
EUR 402
Description: A polyclonal antibody against VHL. Recognizes VHL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

Gene Knock-Out HR Targeting Vector w/Single Selection Marker (Blasticidin) and Negative Selection (TK) Against Random Integration
HR720PA-1 10 µg
EUR 1374

Mouse pre-microRNA Expression Construct mir-293+294+295
MMIR-293-295-PA-CL Bacterial Streak
EUR 1161.6

293AAV Cell Line
AAV-100 1 vial
EUR 609.6
Description: The 293AAV Cell Line is derived from the parental 293 cells but selected for attributes that increase AAV production, including firmer attachment and larger surface area.

293AD Cell Line
AD-100 1 vial
EUR 553.2
Description: The 293AD Cell Line is derived from the parental 293 cells but selected for attributes that increase adenovirus production, including firmer attachment and larger surface area.

293LTV Cell Line
LTV-100 1 vial
EUR 609.6
Description: The 293LTV Cell Line is derived from the parental 293 cells but selected for attributes that increase lentiviral production, including fimrer attachment and larger surface area.

293RTV Cell Line
RV-100 1 vial
EUR 609.6
Description: The 293RTV Cell Line is derived from the parental 293 cells but selected for attributes that increase retroviral production, including fimrer attachment and larger surface area.

Human VHL shRNA Plasmid
20-abx955082
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

VHL ELISA KIT|Human
EF006088 96 Tests
EUR 826.8

Human VHL ELISA Kit
ELA-E1894h 96 Tests
EUR 988.8

VHL Recombinant Protein (Human)
RP034324 100 ug Ask for price

Gene Knock-Out HR Targeting Vector w/Dual Selection Markers (GFP+Puro) and Negative Selection (TK) Against Random Integration
HR700PA-1 10 µg
EUR 1374

Gene Knock-Out HR Targeting Vector w/Dual Selection Markers (RFP+Hygro) and Negative Selection (TK) Against Random Integration
HR710PA-1 10 µg
EUR 1374

VHL sgRNA CRISPR Lentivector (Human) (Target 1)
K2611302 1.0 ug DNA
EUR 184.8

VHL sgRNA CRISPR Lentivector (Human) (Target 2)
K2611303 1.0 ug DNA
EUR 184.8

VHL sgRNA CRISPR Lentivector (Human) (Target 3)
K2611304 1.0 ug DNA
EUR 184.8

T47D/GFP Cell Line
AKR-208 1 vial
EUR 686.4
Description: T47D/GFP Cell Line stably expresses GFP and otherwise exhibits the same characteristics of the parental cell line.

A549/GFP Cell Line
AKR-209 1 vial
EUR 686.4
Description: A549/GFP Cell Line stably expresses GFP and otherwise exhibits the same characteristics of the parental cell line.

HeLa/GFP Cell Line
AKR-213 1 vial
EUR 686.4
Description: HeLa/GFP Cell Line stably expresses GFP and otherwise exhibits the same characteristics of the parental cell line.

NIH3T3/GFP Cell Line
AKR-214 1 vial
EUR 686.4
Description: NIH3T3/GFP Cell Line stably expresses GFP and otherwise exhibits the same characteristics of the parental cell line.

NIH3T3/Cas9 Cell Line
AKR-5104 1 vial
EUR 686.4

HeLa/Cas9 Cell Line
AKR-5111 1 vial
EUR 686.4

TARGATT? Knock-in iPSC Genotyping Kit
AST-1102 1 Kit Ask for price
Description: 12 month

Microplate Swing-Out Centrifuge
abx725026-1Unit 1 Unit
EUR 1771.2

Clinical Swing-Out Centrifuge
abx725027-1Unit 1 Unit
EUR 1771.2

Gene Knock-Out HR Targeting Vector with TK selection [MCS1-LoxP-EF1?-GFP-T2A-Puro-P2A-hsvTK-pA-LoxP-MCS2]
HR210PA-1 10 ug
EUR 1374

VHL Rabbit pAb
A0377-100ul 100 ul
EUR 369.6

VHL Rabbit pAb
A0377-200ul 200 ul
EUR 550.8

VHL Rabbit pAb
A0377-20ul 20 ul
EUR 219.6

VHL Rabbit pAb
A0377-50ul 50 ul
EUR 267.6

VHL Mouse mAb
A11872-100ul 100 ul Ask for price

VHL Mouse mAb
A11872-200ul 200 ul Ask for price

VHL Mouse mAb
A11872-20ul 20 ul Ask for price

VHL Mouse mAb
A11872-50ul 50 ul
EUR 318

VHL Rabbit pAb
A11240-100ul 100 ul
EUR 369.6

VHL Rabbit pAb
A11240-200ul 200 ul
EUR 550.8

VHL Rabbit pAb
A11240-20ul 20 ul
EUR 219.6

VHL Rabbit pAb
A11240-50ul 50 ul
EUR 267.6

VHL Polyclonal Antibody
46866-100ul 100ul
EUR 302.4

VHL Polyclonal Antibody
46866-50ul 50ul
EUR 224.4

  • Sufferers within the nHM group had the next danger of pheochromocytoma (HR = 3.447, p < 0.001) and decrease dangers of central nervous system hemangioblastoma (CHB) (HR = 0.700, p = 0.045), renal cell carcinoma (HR = 0.610, p = 0.024), and pancreatic tumor (HR = 0.382, p < 0.001) than these within the mixed HM and TR (HMTR) group.

 

  • Furthermore, nHM mutations had been independently related to better general survival (HR = 0.345, p = 0.005) and CHB-specific survival (HR = 0.129, p = 0.005) than HMTR mutations.

 

  • The modified genotype-phenotype correlation hyperlinks VHL gene mutation, substrate binding web site, and phenotypic range (penetrance and survival), and offers extra correct data for genetic counseling and pathogenesis research.

 

Ronald

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